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Method and solution for organ preservation comprising retinal-derived growth factor, cyclodextrin, mucopolysaccharide an 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A01N-001/02
  • C12N-005/00
출원번호 US-0476456 (1995-06-07)
발명자 / 주소
  • Brasile Lauren (Albany NY) Clarke Jolene (Ballston Spa NY)
출원인 / 주소
  • Alliance Pharmaceutical Corp. (San Diego CA 02)
인용정보 피인용 횟수 : 70  인용 특허 : 9

초록

The present invention is directed to a new preservation solution useful for the initial flushing and for the storage of organs intended for transplantation using a warm preservation technology, between 18°C. and 37°C. Among the components of the preservation solution are a basal mammalian cell cultu

대표청구항

A method for preserving an organ prior to transplantation, comprising the steps of: flushing an organ with a preservation solution comprising one or more serum proteins, retinal-derived growth factor in a range of about 0.001-5 g/L, one or more mucopolysaccharides, cyclodextrin, and emulsified liqui

이 특허에 인용된 특허 (9)

  1. Long ; Jr. David M. (San Diego CA), Biocompatible stable fluorocarbon emulsions for contrast enhancement and oxygen transport comprising 40-125% wt./volume.
  2. Segall Paul E. (Berkeley CA) Waitz Harold D. (Berkeley CA) Sternberg Hal (Berkeley CA), Blood substitute.
  3. O\Dell Bobby J. (San Antonio TX), Combined perfusion and oxygenation organ preservation apparatus.
  4. Runge Thomas M. (2630 Exposition Blvd. Austin TX 78703), Hyperosmolar oxyreplete hemosubstitute.
  5. Bretan ; Jr. Peter D. (Novato CA), Intracellular flush solution for preserving organs.
  6. O\Dell Bobby J. (San Antonio TX) Bunegin Leonid (San Antonio TX), Method for hypothermic preservation of living tissue.
  7. Sheffield Warren D. (Lebanon NJ), Method for preventing tissue damage after an ischemic episode.
  8. Long ; Jr. David M. (Villa Park IL), Non-toxic brominated perfluorocarbons radiopaque agents.
  9. Clark ; Jr. Leland C. (Cincinnati OH) Moore Robert E. (Wilmington DE), Selecting perfluorocarbon compounds for synthetic blood.

이 특허를 인용한 특허 (70)

  1. Ritchie, Greg; Lambert, II, Vincent; Bringham, Richard; Sullivan, John; Hassanein, Waleed H., Aortic cannula for ex vivo organ care system.
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  3. Owen, Donald R.; Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Isaacs, Dickon; Schein, Douglas, Apparatus and method for maintaining and/or restoring viability of organs.
  4. Owen, Donald R.; Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Isaacs, Dickon; Schein, Douglas, Apparatus and method for maintaining and/or restoring viability of organs.
  5. Owen, Donald R.; Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Isaacs, Dickon; Schein, Douglas, Apparatus and method for maintaining and/or restoring viability of organs.
  6. Owen, Donald R.; Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Isaacs, Dickon; Steibel, Dennis J.; Fraser, Richard; Harris, Stanley; Schein, Douglas, Apparatus and method for maintaining and/or restoring viability of organs.
  7. Owen, Donald R.; Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Isaacs, Dickon; Steibel, Dennis J.; Fraser, Richard; Harris, Stanley; Schein, Douglas, Apparatus and method for maintaining and/or restoring viability of organs.
  8. Owen, Donald R.; Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Isaacs, Dickon; Steibel, Dennis; Fraser, Richard; Harris, Stanley; Schein, Douglas, Apparatus and method for maintaining and/or restoring viability of organs.
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  20. Wright, David Walter; Garland, Jeffrey C., Device for separating gas from a liquid path.
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  29. Schein, Douglas; Travis, Lee William, Method and apparatus for holding a plurality of tubes connectible to an organ or tissue container.
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