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Microspheres comprising polymer and drug dispersed there within 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-009/50
  • A61K-009/52
  • B01J-013/12
출원번호 US-0691874 (1996-08-02)
발명자 / 주소
  • Mathiowitz Edith
  • Mullon Claudy J.P.
  • Domb Abraham J.
  • Langer Robert S.
출원인 / 주소
  • Massachusetts Institute of Technology
대리인 / 주소
    Arnall Golden & Gregory, LLP
인용정보 피인용 횟수 : 72  인용 특허 : 5

초록

Using these embodiments, alone or in combination with other methods including the "hot melt" technique, multi-walled microspheres having each wall degrading at a different rate or containing different drugs can be manufactured.

대표청구항 ▼

[ We claim:] [1.] Microspheres comprising a polymer and a drug dispersed within each microsphere, whereby the microspheres are formed in the absence of water by extraction into an organic oil of a volatile organic solvent from a non-aqueous solution of the polymer and the drug in the volatile organi

이 특허에 인용된 특허 (5)

  1. Beck Lee R. (Birmingham AL) Flowers ; Jr. Charles F. (Birmingham AL) Cowsar Donald R. (Birmingham AL) Tanquary Albert C. (Birmingham AL), Active/passive immunization of the internal female reproductive organs.
    상세보기
  2. Langer Robert S. (Somerville MA) Rosen Howard (Montara CA) Linhardt Robert J. (Iowa City IA) Leong Kam (Cambridge MA), Bioerodible polyanhydrides for controlled drug delivery.
    상세보기
  3. Ziegast Gerd (Liestal CHX), Poly-dicaboxylic acid anhydrides and polymeric anhydrides therefrom.
    상세보기
  4. Fong Jones W. (Parsippany NJ), Process for preparation of microspheres and modification of release rate of core material.
    상세보기
  5. Gardner David L. (Bellville OH), Process of preparing microcapsules of lactides or lactide copolymers with glycolides and/or e 상세보기

이 특허를 인용한 특허 (72)

  1. Zeligs, Michael A., Anti-parasitic methods and compositions utilizing diindolylmethane-related indoles.
    상세보기
  2. Zeligs, Michael A., Anti-parasitic methods and compositions utilizing diindolylmethane-related indoles.
    상세보기
  3. Zeligs, Michael A., Anti-parasitic methods and compositions utilizing diindolylmethane-related indoles.
    상세보기
  4. Ambrose, Catherine G.; Clyburn, Terry A.; Mikos, Antonio G., Antibiotic microspheres for treatment and prevention of osteomyelitis and enhancement of bone regrowth.
    상세보기
  5. Hanes,Justin; Fu,Jie; Fiegel,Jennifer, Biodegradable polymer compositions, compositions and uses related thereto.
    상세보기
  6. Popov, Alexey; Enlow, Elizabeth M.; Chen, Hongming; Bourassa, James, Compositions and methods for ophthalmic and/or other applications.
    상세보기
  7. Thanoo Bagavathikanun Chithambara ; Murtagh James, Continuous microsphere process.
    상세보기
  8. Asgarzadeh, Firouz; Costantino, Henry R., Crosslinked hydrogel copolymers.
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  9. Shastri, Venkatram P., Degradable polymers from derivatized ring-opened epoxides.
    상세보기
  10. Evans, Douglas G.; Goldman, Scott M.; Kronengold, Russell T., Devices and methods for treating defects in the tissue of a living being.
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  11. Evans, Douglas G; Goldman, Scott M.; Kronengold, Russell T., Devices and methods for treating defects in the tissue of a living being.
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  12. Evans, Douglas G; Goldman, Scott M.; Kronengold, Russell T., Devices and methods for treating defects in the tissue of a living being.
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  13. Evans, Douglas G; Goldman, Scott M.; Kronengold, Russell T., Devices and methods for treating defects in the tissue of a living being.
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  14. Evans, Douglas G; Goldman, Scott M.; Kronengold, Russell T., Devices and methods for treating defects in the tissue of a living being.
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  15. Evans, Douglas G; Goldman, Scott M.; Kronengold, Russell T., Devices and methods for treating defects in the tissue of a living being.
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  16. Evans, Douglas G; Goldman, Scott M.; Kronengold, Russell T., Devices and methods for treating defects in the tissue of a living being.
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  17. Evans, Douglas G; Goldman, Scott M.; Kronengold, Russell T., Devices and methods for treating defects in the tissue of a living being.
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  18. Evans,Douglas G.; Goldman,Scott M.; Kronengold,Russell T., Devices and methods for treating defects in the tissue of a living being.
    상세보기
  19. Evans,Douglas G.; Goldman,Scott M.; Kronengold,Russell T., Devices and methods for treating defects in the tissue of a living being.
    상세보기
  20. Evans,Douglas G.; Goldman,Scott M.; Kronengold,Russell T., Devices and methods for treating defects in the tissue of a living being.
    상세보기
  21. Evans,Douglas G; Goldman,Scott M.; Kronengold,Russell T., Devices and methods for treating defects in the tissue of a living being.
    상세보기
  22. Dellamary,Luis A.; Tarara,Thomas E.; Kabalnov,Alexey; Weers,Jeffry G.; Schutt,Ernest G., Dispersion for pulmonary delivery of a bioactive agent.
    상세보기
  23. Hanes, Justin; Dawson, Michelle Rose; Wirtz, Denis; Fu, Jie; Krauland, Eric Mark, Drugs and gene carrier particles that rapidly move through mucous barriers.
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  24. Gibson John W. ; Holl Richard J. ; Tipton Arthur J., Emulsion-based processes for making microparticles.
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  25. John W. Gibson ; Richard J. Holl ; Arthur J. Tipton, Emulsion-based processes for making microparticles.
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  26. Tarara, Thomas E.; Weers, Jeffry G.; Kabalnov, Alexey; Schutt, Ernest G.; Dellamary, Luis A., Engineered particles and methods of use.
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  27. Tarara,Thomas E.; Weers,Jeffry G.; Kabalnov,Alexey; Schutt,Ernest G.; Dellamary,Luis A., Engineered particles and methods of use.
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  28. Bangera, Mahalaxmi Gita; Boyden, Edward S.; Hyde, Roderick A.; Ishikawa, Muriel Y.; Rivet, Dennis J.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L.; Wood, Victoria Y. H., Ex vivo modifiable multiple medicament final dosage form.
    상세보기
  29. Tarara, Thomas E.; Weers, Jeffry G.; Eldon, Michael A.; Narashimhan, Rangachari; Clark, Andrew, Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use.
    상세보기
  30. Patel, Rajesh A.; Bucalo, Louis R.; Costantini, Lauren; Kleppner, Sofie, Implantable polymeric device for sustained release of dopamine agonist.
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  31. Patel, Rajesh A.; Bucalo, Louis R.; Costantini, Lauren; Kleppner, Sofie, Implantable polymeric device for sustained release of dopamine agonist.
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  32. Bagavathikanun Chithambara Thanoo ; James Murtagh, Method and apparatus for formulating microspheres and microcapsules.
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  33. Thanoo Bagavathikanun Chithambara ; Murtagh James, Method and apparatus for formulating microspheres and microcapsules.
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  34. Sullivan Radmila ; Kidd Marvin L. ; Lafferty Patrick Alan, Method for preparing a core material containment system and the core material containment system prepared thereby.
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  35. Mathiowitz, Edith; Thanos, Christopher; Liu, Zhi, Methods for micronization of hydrophobic drugs.
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  36. Mathiowitz, Edith; Thanos, Christopher; Liu, Zhi, Methods for micronization of hydrophobic drugs.
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  37. Mathiowitz, Edith; Thanos, Christopher; Liu, Zhi, Methods for micronization of hydrophobic drugs.
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  38. Tarara, Thomas E.; Weers, Jeffry G.; Kabalnov, Alexey; Schutt, Ernest G.; Dellamary, Luis A., Methods of spray drying pharmaceutical compositions.
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  39. Popov, Alexey; Enlow, Elizabeth M.; Bourassa, James; Gardner, Colin R.; Chen, Hongming; Ensign, Laura M.; Lai, Samuel K.; Yu, Tao; Hanes, Justin; Yang, Ming, Nanocrystals, compositions, and methods that aid particle transport in mucus.
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  40. Ma, Peter X.; Zhang, Zhanpeng, Nanofibrous spongy microspheres.
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  41. Weers, Jeffry G.; Tarara, Thomas E.; Dellamary, Luis A.; Riess, Jean G.; Schutt, Ernest G., Phospholipid-based powders for drug delivery.
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  42. Weers, Jeffry G; Tarara, Thomas E; Dellamary, Luis A; Riess, Jean G; Schutt, Ernest G, Phospholipid-based powders for drug delivery.
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  43. Weers,Jeffry G.; Tarara,Thomas E.; Dellamary,Luis A.; Riess,Jean G.; Schutt,Ernest G., Phospholipid-based powders for drug delivery.
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  44. Dixon, Hong; McDonough, Joseph A, Processing of heat-sensitive active agents.
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  45. Tarara, Thomas E.; Weers, Jeffry G.; Venthoye, Geraldine, Pulmonary delivery of aminoglycoside.
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  46. Tarara, Thomas E; Weers, Jeffry G; Venthoye, Maria Geraldine, Pulmonary delivery of aminoglycoside.
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  47. Tarara,Thomas E.; Weers,Jeffry G.; Venthoye,Geraldine, Pulmonary delivery of aminoglycosides.
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  48. Tarara, Thomas E.; Weers, Jeffrey G.; Kabalnov, Alexey; Schutt, Ernest G.; Dellamary, Luis A., Pulmonary delivery particles comprising an active agent.
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  49. Weers, Jeffry G.; Schutt, Ernest G.; Dellamary, Luis A.; Tarara, Thomas E.; Kabalnov, Alexey, Respiratory dispersion for metered dose inhalers comprising perforated microstructures.
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  50. Dellamary,Luis A.; Tarara,Thomas; Kabalnov,Alexey; Weers,Jeffry; Schutt,Ernest, Stabilized bioactive preparations and method of use.
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  51. Luis A. Dellamary ; Thomas E. Tarara ; Alexey Kabalnov ; Jeffry G. Weers ; Ernest G. Schutt, Stabilized bioactive preparations and methods of use.
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  52. Weers, Jeffry G.; Schutt, Ernest G.; Dellamary, Luis A.; Tarara, Thomas E.; Kabalnov, Alexey, Stabilized preparation for use in metered dose inhalers.
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  53. Weers Jeffry G. ; Schutt Ernest G. ; Dellamary Luis A. ; Tarara Thomas E. ; Kabalnov Alexey, Stabilized preparations for use in metered dose inhalers.
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  54. Weers, Jeffry G.; Schutt, Ernest G.; Dellamary, Luis; Tarara, Thomas E.; Kabalnov, Alexey, Stabilized preparations for use in metered dose inhalers.
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  55. Schutt, Ernest G.; Tarara, Thomas E.; Dellamary, Luis A.; Kabalnov, Alexey; Weers, Jeffry G., Stabilized preparations for use in nebulizers.
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  56. Dellamary, Luis A.; Reiss, Jean; Schutt, Ernest G.; Weers, Jeffry G.; Tarara, Thomas E., Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery.
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  57. Dellamary, Luis A.; Riess, Jean; Schutt, Ernest G.; Weers, Jeffry G.; Tarara, Thomas E., Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use.
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  58. Dellamary, Luis A; Riess, Jean; Schutt, Ernest G; Weers, Jeffry G; Tarara, Thomas E, Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use.
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  59. Nash, John E.; Evans, Douglas G.; Hoganson, David M., Systems and methods for delivering agents into targeted tissue of a living being.
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  61. Nash,John E.; Evans,Douglas G.; Hoganson,David M., Systems and methods for delivering agents into targeted tissue of a living being.
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  62. Soltani, Azita; Hansmann, Douglas R., Treatment of vascular occlusions using ultrasonic energy and microbubbles.
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  63. Soltani,Azita; Hansmann,Douglas R., Treatment of vascular occlusions using ultrasonic energy and microbubbles.
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  64. Keilman, George; Hansmann, Douglas R.; Soltani, Azita; Wilson, Richard R., Ultrasonic catheter power control.
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  65. Keilman, George; Hansmann, Douglas R.; Soltani, Azita; Wilson, Richard R., Ultrasonic catheter power control.
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  66. Keilman, George; Hansmann, Douglas R.; Soltani, Azita; Wilson, Richard R., Ultrasonic catheter power control.
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  67. Bennett, Frederick J.; Rodriguey, James E., Ultrasound assembly with increased efficacy.
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  68. Bennett, Frederick J.; Zhang, John; Lichttenegger, Gary; Rodriguey, James E.; Tachibana, Katsuro, Ultrasound catheter for providing a therapeutic effect to a vessel of a body.
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  69. Wilson, Richard R., Ultrasound radiating members for catheter.
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  70. Soltani, Azita; Prokop, Adrian F., Ultrasound therapy system.
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  71. Zeligs, Michael A., Use of diindolylmethane-related indoles for the treatment and prevention of respiratory syncytial virus associated conditions.
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  72. Zeligs, Michael A., Use of diindolylmethane-related indoles for the treatment and prevention of respiratory syncytial virus associated conditions.
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