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Non-crosslinked protein particles for therapeutic and diagnostic use 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-009/64
  • A61K-047/42
  • B01J-013/00
출원번호 US-0471650 (1995-06-06)
발명자 / 주소
  • Yen Richard C. K.
출원인 / 주소
  • Hemosphere, Inc.
대리인 / 주소
    Townsend & Townsend & Crew
인용정보 피인용 횟수 : 35  인용 특허 : 12

초록

Albumin particles in the nanometer and micrometer size range in an aqueous suspension are rendered stable against resolubilization without the aid of a crosslinking agent and without denaturation, by the incorporation of a stabilizing agent in the particle composition. Particles which are primarily

대표청구항

[ What is claimed is:] [1.] A method for the preparation of an aqueous suspension of monodisperse non-crosslinked particles of albumin having a size range of from about 50 to about 5000 nanometers in diameter and stable against resolubilization, said method comprising:(a) forming an aqueous solution

이 특허에 인용된 특허 (12)

  1. Yapel ; Jr. Anthony F. (Saint Paul MN), Albumin medicament carrier system.
  2. Ecanow Bernard (Wilmette IL), Drug delivery compositions and methods.
  3. Gibson Suzanne M. (Piscataway NJ) Strauss George (Piscataway NJ) Wasserman Bruce P. (Belle Mead NJ), Heat stable fat substitute compositions and process.
  4. Arai Motoharu (Tokyo JPX) Ito Masatsugu (Tokyo JPX), Lipid powder having cross-linked coating thereon and process for preparing same.
  5. Yen Richard C. K. (4261 Chase Ave. Los Angeles CA 90066), Manufacturing protein microspheres.
  6. Ekman Bo (MalmSEX) Lindahl ke (Skurup SEX), Method for producing small, spherical polymer particles.
  7. Spence Kemet D. (Potlatch ID) Andrews Robert E. (Pullman WA), Microbial insecticide.
  8. Chen Wehn-Sherng (Glenview IL) Henry George A. (Wilmette IL) Gaud Susan M. (Evanston IL) Miller Mark S. (Arlington Heights IL) Kaiser John M. (Glenview IL) Balmaceda Estela A. (Winnetka IL) Morgan Ro, Microfragmented ionic polysaccharide/protein complex dispersions.
  9. DeLuca Patrick P. (Lexington KY) Kanke Motoko (Fukuyama JPX) Sato Toyomi (Tokyo CA JPX) Schroeder Hans G. (Encinitas CA), Porous microspheres for drug delivery and methods for making same.
  10. Chia Han-Lie (Reinach CHX) Woltmann Siegfried (Magden CHX), Process for the preparation of physiologically degradable, colloidal radioisotope carriers and their use.
  11. Yen Richard C. K. (Glendora CA), Protein nanomatrixes and method of production.
  12. Kunihiro Yasuyuki (Shinjuku JPX) Tanaka Ryo (Shinjuku JPX) Hata Seishichi (Shinjuku JPX) Yamada Koji (Shinjuku JPX), Thrombin composition for oral administration.

이 특허를 인용한 특허 (35)

  1. Yen, Richard C. K., Biologic devices for hemostasis.
  2. Roy Harris GB; Nicholas David Osborne GB, Complex of DNA and microparticle of defatted lipid-binding protein for gene therapy.
  3. Quay,Steven C.; Brandt,Gordon, Compositions and methods for enhanced mucosal delivery and non-infused administration of Y2 receptor-binding peptides and methods for treating and preventing obesity.
  4. Quay,Steven C.; Brandt,Gordon; Kleppe,Mary S.; MacEvilly,Conor J., Compositions and methods for enhanced mucosal delivery of Y2 receptor-binding peptides and methods for treating and preventing obesity.
  5. Quay,Steven C.; Brandt,Gordon; Kleppe,Mary S.; MacEvilly,Conor J., Compositions and methods for enhanced mucosal delivery of Y2 receptor-binding peptides and methods for treating and preventing obesity.
  6. Quay,Steven C.; Brandt,Gordon; Kleppe,Mary S.; MacEvilly,Conor J., Compositions and methods for enhanced mucosal delivery of Y2 receptor-binding peptides and methods for treating and preventing obesity.
  7. Quay,Steven C, Compositions and methods for enhanced mucosal delivery of peptide YY and methods for treating and preventing obesity.
  8. De, Tapas; Desai, Neil P.; Yang, Andrew; Yim, Zachary; Soon-Shiong, Patrick, Compositions and methods for preparation of poorly water soluble drugs with increased stability.
  9. De, Tapas; Desai, Neil P.; Yang, Andrew; Yim, Zachary; Soon-Shiong, Patrick, Compositions and methods for preparation of poorly water soluble drugs with increased stability.
  10. De, Tapas; Desai, Neil P; Yang, Andrew; Yim, Zachary; Soon-Shiong, Patrick, Compositions and methods for preparation of poorly water soluble drugs with increased stability.
  11. Desai, Neil P.; Selvaraj, Raj; Yang, Andrew; Soon-Shiong, Patrick, Compositions comprising poorly water soluble pharmaceutical agents and antimicrobial agents.
  12. Yen Richard C. K., Fibrinogen-coated microspheres.
  13. Richard C. K. Yen, Fibrinogen-coated particles for therapeutic use.
  14. Hook Magnus ; Lindberg Kjell Martin,SEX ; Lindgren Per-Eric,SEX ; Signas Lars Christer,SEX, Fibronectin binding protein.
  15. Gardiner Paul T.,CAXITX L6S 2H6, Food supplements and methods comprising lipoic acid and creatine.
  16. Gardiner, Paul T., Food supplements and methods comprising lipoic acid and creatine.
  17. Desai, Neil P.; Soon-Shiong, Patrick, Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof.
  18. Desai, Neil P.; Tao, Chunlin; Yang, Andrew; Louie, Leslie; Soon-Shiong, Patrick, Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof.
  19. Prasad Chandan, Histidyl-proline diketopiperazine and method of use.
  20. Aoki Hiroe,JPX ; Hara Eijiro,JPX ; Hirao Tetsuji,JPX, Inhibition of abnormal accumulation of extra-cellular matrices.
  21. Woiszwillo James E. ; Brown Larry R. ; Scott Terrence L. ; Di Jie ; Sudhalter Judith ; Blizzard Charles D., Macromolecular microparticles and methods of production and use.
  22. Woiszwillo James E. ; Brown Larry R. ; Scott Terrence L. ; Di Jie ; Sudhalter Judith ; Blizzard Charles D. ; Riske Frank J., Macromolecular microparticles and methods of production and use.
  23. Woiszwillo James E. ; Brown Larry R. ; Scott Terrence L. ; Di Jie ; Sudhalter Judith ; Blizzard Charles D. ; Riske Frank J., Macromolecular microparticles and methods of production and use.
  24. Bousquet Gagnon,Nathalie; Quraishi,Omar; Bridon,Dominique P., Method for purification of albumin conjugates.
  25. Bridon, Dominique P.; Castaigne, Jean-Paul; Thibaudeau, Karen, Method of treatment of diabetes and/or obesity with reduced nausea side effect.
  26. Lin, Henry C., Methods for manipulating satiety.
  27. Lin, Henry C., Methods for manipulating satiety.
  28. Lin,Henry C., Methods for manipulating upper gastrointestinal transit, blood flow, and satiety, and for treating visceral hyperalgesia.
  29. Lin,Henry C., Methods for manipulating upper gastrointestinal transit, blood flow, and satiety, and for treating visceral hyperalgesia.
  30. Lin, Henry C., Methods for treating irritable bowel syndrome.
  31. Lin, Henry C.; Pimentel, Mark, Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions.
  32. Lin, Henry C.; Pimentel, Mark, Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions.
  33. Lin, Henry C.; Pimentel, Mark, Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions.
  34. Lin, Henry C.; Pimentel, Mark, Methods of treating autoimmune diseases caused by small intestinal bacterial overgrowth.
  35. Heath David,GBX ; Middleton Sarah Margaret,GBX ; Harris Roy,GBX ; Church Nicola Jane,GBX, Platelet substitutes and conjugation methods suitable for their preparation.
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