초록 ▼

The invention is directed to a device for delivering an active agent formulation for a predetermined administration period. An impermeable reservoir is divided into a water-swellable agent chamber and an active agent formulation chamber. Fluid from the environment is imbibed through a semipermeable

The invention is directed to a device for delivering an active agent formulation for a predetermined administration period. An impermeable reservoir is divided into a water-swellable agent chamber and an active agent formulation chamber. Fluid from the environment is imbibed through a semipermeable plug into the water-swellable agent chamber and the active agent formulation is released through a back-diffusion regulating outlet. Delivery periods of up to 2 years are achieved.

대표청구항 ▼

[ We claim:] [1.] An implantable leuprolide delivery system comprising:(a) an impermeable reservoir;(b) a piston that divides the reservoir into a first and a second chamber, the first and second chambers each having an open end;(c) a water-swellable agent formulation in the first chamber;(d) a leup

[ We claim:] [1.] An implantable leuprolide delivery system comprising:(a) an impermeable reservoir;(b) a piston that divides the reservoir into a first and a second chamber, the first and second chambers each having an open end;(c) a water-swellable agent formulation in the first chamber;(d) a leuprolide formulation in the second chamber;(e) a semipermeable plug in the open end of the first chamber; and(f) a back-diffusion regulating outlet in the open end of the second chamber;wherein the system effectively seals the second chamber and isolates the leuprolide formulation from the environment of use.