Combinations, called matrices with memories, of matrix materials with remotely addressable or remotely programmable recording devices that contain at least one data storage unit are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical synthese
Combinations, called matrices with memories, of matrix materials with remotely addressable or remotely programmable recording devices that contain at least one data storage unit are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The data storage units are preferably non-volatile antifuse memories. By virtue of this combination, molecules and biological particles, such as phage and viral particles and cells, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. Combinations of matrix materials, memories, and linked molecules and biological materials are also provided. The combinations have a multiplicity of applications, including combinatorial chemistry, isolation and purification of target macromolecules, capture and detection of macromolecules for analytical purposes, selective removal of contaminants, enzymatic catalysis, chemical modification and other uses.
대표청구항▼
[ What is claimed:] [1.] A system for programming and reading data from a combination of a matrix with memory, comprising:(A) a host computer or decoder/encoder instrument having a memory for storing data:(i) relating to one or a plurality of process steps for synthesizing, assaying or reacting mole
[ What is claimed:] [1.] A system for programming and reading data from a combination of a matrix with memory, comprising:(A) a host computer or decoder/encoder instrument having a memory for storing data:(i) relating to one or a plurality of process steps for synthesizing, assaying or reacting molecules or biological particles in contact with the combination, relating to the identity of a molecule, or a biological particle, or to information categorizing the molecule or biological particle, wherein the biological particle is a virus, viral vector, viral capsid with or without packaged nucleic acid, phage, a phage vector, phage capsid, a cell or fragments thereof;(ii) for identifying one or a plurality of unique indicators representative of each of the process steps or the identity or category of molecule or biological particle; and(iii) for generating a data signal representative of each unique indicator;(B) a transmitter means for receiving a data signal and generating a transmitted signal for transmitting a data signal, and for providing a write signal;(C) the combination of matrix with memory in contact with or in a solution containing a molecule or biological particle, wherein the combination of matrix with memory, comprises:(i) a recording device, comprising an electromagnetically remotely programmable data storage unit;and(ii) a matrix material, wherein:the matrix material is either comprised of particles of a size such that at least one dimension is no more than 5 to 10 mm or the matrix material is in the form of a solid continuous surface that encases the recording device;the matrix is derivatized for retaining products of each of the combination of process steps, the matrix being non-reactive with the plurality of process steps; andthe recording device is in contact with the matrix or in a solution that is in contact with the matrix, and comprises:non-volatile memory means for storing a plurality data points and means for receiving the transmitted signal so that the write signal causes a stored data point corresponding to the data signal to be stored within the non-volatile memory means;(D) means for reading from the non-volatile memory means to identify each of the stored data points, wherein the stored data points indicate exposure of the combination of matrix with memory to one of a combination of process steps or the identity or category of the molecule or biological particle.
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