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Method of fluorescence analysis comprising evanescent wave excitation and out-of-plane photodetection 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • G01N-021/41
  • G01N-021/00
출원번호 US-0489436 (1995-06-12)
발명자 / 주소
  • Groger Howard P.
  • Lo K. Peter
  • Weiss Martin
출원인 / 주소
  • American Research Corporation of Virginia
대리인 / 주소
    Wray
인용정보 피인용 횟수 : 13  인용 특허 : 23

초록

Fluorescence measuring methods and apparatus use planar optical waveguides to excite fluorescence in the evanescent field of the waveguides and photodetectors to sense the fluorescence produced. Chemically sensitive fluorophores are bound to the evanescent regions of the planar optical waveguides. S

대표청구항

[ We claim:] [1.] A sensor apparatus for detecting fluorescence comprising a substrate, a waveguide comprising two or more dielectric layers positioned on the substrate, a chemically sensitive fluorophore film positioned over the waveguide, an excitation source positioned near the waveguide for deli

이 특허에 인용된 특허 (23)

  1. Keck Donald B. (Big Flats NY) Love Walter F. (Horseheads NY), Dielectric waveguide sensors and their use in immunoassays.
  2. Porter Marc D. (Ames IA) Jones Thomas P. (Waukesha WI) Coldiron Shelley J. (Ames IA), Dual-wavelength photometer and fiber optic sensor probe.
  3. Ackley Donald E. (Lambertville NJ) Krihak Michael (Kenilworth NJ) Shieh Chan-Long (Paradise Valley AZ), Environmental sensor and method therefor.
  4. Slovacek Rudolf E. (Norfolk MA) Love Walter F. (Horseheads NY), Evanescent wave sensor shell and apparatus.
  5. Cook Thomas A. (Corning NY) Love Walter F. (Horseheads NY) Slovacek Rudolf E. (Norfolk MA), Evanescent wave sensors.
  6. Padovani Francois A. (Westwood MA), Fiber optic chemical sensor.
  7. Curtis Alan C. (Somerset GB3), Fibre optic sensor.
  8. Attridge John W. (Woking Surrey GBX), Fluorescent assay and sensor therefor.
  9. Block Myron J. (North Salem NH) Hirschfeld Tomas B. (Livermore CA), Fluorescent assays, including immunoassays, with feature of flowing sample.
  10. Attridge John W. (Weybridge GBX), Method of optical analysis of a fluid including an optical waveguide.
  11. Kirschen Morris (Modesto CA), Method to test for chemically hardened glass lenses.
  12. Slovacek Rudolf E. (Norfolk MA) Love Walter F. (Horseheads NY) Cook Thomas A. (Corning NY) Schulkind Richard L. (Sharon MA) Walczak Irene M. (Boston MA), Multiple surface evanescent wave sensor with a reference.
  13. Saaski Elric W. (Bothell WA) McCrae David A. (Seattle WA) Hartl James C. (Snohomish WA) Lawrence Dale M. (Lynnwood WA) Wolthuis Roger A. (Woodinville WA), Optical pH and gas concentration sensor.
  14. Murray ; Jr. Richard C. (Palatine IL) Lefkowitz Steven M. (Hoffman Estates IL), Optical sensor for monitoring the partial pressure of oxygen.
  15. Tiefenthaler Kurt (Zrich CHX) Lukosz Walter (Greifensee CHX), Optical sensor for selective detection of substances and/or for the detection of refractive index changes in gaseous, li.
  16. Batchelder David N. (London GB3) Willson Jolyon P. (Duxford GB3), Optical surface plasmon sensor device.
  17. Ackley Donald E. (Phoenix AZ) Lebby Michael S. (Chandler AZ), Optical waveguide apparatus and method for partially collecting light.
  18. Sultan Michel F. (Troy MI) Krage Mark K. (Royal Oak MI), Planar polymer light guide methods and apparatus.
  19. Franke Hilmar (Bramsche DEX), Polyimide waveguides as optical sensors.
  20. Hoffmaster, Timothy D., Process for measuring fluorescence.
  21. Kleinerman Marcos (24 Jerome St. Southbridge MA 01550), Remote measurement of physical variables with fiber optic systems - methods, materials and devices.
  22. Thompson Richard B. (Baltimore MD) Villarruel Carl A. (Burke VA), Waveguide-binding sensor for use with assays.
  23. Johnson Lawrence A. (Plymouth MN), Wavelength coded resonant optical sensor.

이 특허를 인용한 특허 (13)

  1. Kao Hung Pin ; Schoeniger Joseph ; Yang Nancy, Method and apparatus for enhanced evanescent fluorescence and color filtering using a high refractive index thin film coating.
  2. Chagovetz, Alexander M.; Blair, Steven M.; Jensen, Randy L.; Lowder, Bryan J., Methods and compositions related to quantitative, array based methylation analysis.
  3. Sampas, Nicholas M.; Helbing, Rene P.; Curry, Bo U.; Fouquet, Julie E.; Schembri, Carol T., Methods and materials for detection of target species.
  4. Groger Howard P. ; Raymonda John ; Lo K. Peter ; Reynolds Roger L. ; Sullivan William F. ; Coolbaugh Myron T., Modular probe for total internal reflection fluorescence spectroscopy.
  5. Gates John VanAtta ; Muehlner Dirk Joachim, Optical assembly with a coated component.
  6. Tiefenthaler, Kurt, Optical sensor and optical process for the characterization of a chemical and/or bio-chemical substance.
  7. Tiefenthaler, Kurt, Optical sensor and optical process for the characterization of a chemical and/or bio-chemical substance.
  8. Tiefenthaler, Kurt, Optical sensor and optical process for the characterization of a chemical and/or bio-chemical substance.
  9. Shinn, Alan; Fan, Chiko; Elias, Elias R.; Novitsky, Thomas J.; Dawson, Michael; Richardson, Keith, Reader for conducting assays.
  10. Blair,Steven M., Resonant optical cavities for high-sensitivity high-throughput biological sensors and methods.
  11. Kawano, Yoshiro; Abe, Chikara; Abe, Katsuyuki; Tamura, Keisuke, Total internal reflection fluorescence microscope having a conventional white-light source.
  12. Becker, Charles D., Waveguide-based wireless distribution system and method of operation.
  13. Becker, Charles D., Waveguide-based wireless distribution system and method of operation.
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