[특허]Remotely programmable matrices with memories

Remotely programmable matrices with memories 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	G11C-013/02
출원번호	US-0484504 (1995-06-07)
발명자 / 주소	Nova Michael P. Senyei Andrew E.
출원인 / 주소	IRORI
대리인 / 주소	Seidman
인용정보	피인용 횟수 : 126 인용 특허 : 0

초록 ▼

Combinations, called matrices with memories, of matrix materials with remotely addressable or remotely programmable recording devices that contain at least one data storage unit are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The data storage units are preferably non-volatile antifuse memories. By virtue of this combination, molecules and biological particles, such as phage and viral particles and cells, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. Combinations of matrix materials, memories, and linked molecules and biological materials are also provided. The combinations have a multiplicity of applications, including combinatorial chemistry, isolation and purification of target macromolecules, capture and detection of macromolecules for analytical purposes, selective removal of contaminants, enzymatic catalysis, chemical modification and other uses. Methods for electroniclly tagging molecules are biological particles and matrix support materials and immunoassays and and other methods are also provided.

대표청구항 ▼

[ What is claimed:] [1.] A combination of a matrix with memory, comprising:(A) a recording device, comprising a data storage unit programmed with information that identifies a molecule or biological particle that is proximate to the matrix;(B) a matrix material, and(C) the molecule, biological particle, mixture of molecules, mixture of biological particles or a mixture of molecules and biological particles in proximity to the matrix, wherein:the device is less than about 5 mm.sup.3 in size;the matrix material is in the form of a container used for chemical syntheses;the recording device is in contact with the matrix or in a composition that is in contact with the matrix;the molecules are either linked to the matrix or in a composition that is in contact with the matrix and comprise nucleic acids, oligonucleotides, nucleotides, amino acids, biopolymers, organic molecules, peptides or proteins;the biological particles are either linked to the matrix or in a composition that is in contact with the matrix and comprise viral capsids with or without packaged nucleic acids, phage, phage capsids with or without encapsulated nucleotide acid, eukaryotic cells, prokaryotic cells or fragments thereof; andthe data storage unit is electromagnetically remotely programmable.

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