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Rapidly soluble oral solid dosage forms, methods of making same, and compositions thereof 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-009/20
  • A61K-009/22
출원번호 US-0599277 (1996-02-09)
발명자 / 주소
  • Roser Bruce J.,GBX
  • Blair Julian,GBX
출원인 / 주소
  • Quadrant Holdings Cambridge Ltd., GB2
대리인 / 주소
    Lehnhardt
인용정보 피인용 횟수 : 62  인용 특허 : 24

초록

The invention provides methods of making rapidly soluble tablets of decreased weight compared to similar solid tablets. The invention further provides novel, rapidly soluble tablets of decreased weight compared to similar solid tablets. The tablets offer increased rates of dissolution and disintegra

대표청구항

[ We claim:] [1.] A method of making rapidly soluble tablets comprising the steps of:a) combining, in substantially dry form, components comprising a diluent, an amount of binder sufficient to increase the hardness of the tablets formed to acceptable levels; an amount of an active agent such that ea

이 특허에 인용된 특허 (24)

  1. Lajoie M. Stephen (Basking Ridge NJ), Co-micronized bicarbonate salt compositions.
  2. Puglia Wayne J. (Bellerose Village NY) Patanasinth Kanit J. (Tarrytown NY) Lombardo Andrew T. (Bronx NY) Beam John E. (Norwalk CT) Mackay Donald A. M. (Pleasantville NY), Compressed chewable antacid tablet and method for forming same.
  3. Puglia Wayne J. (Bellerose Village NY) Patanasinth Kanit J. (Tarrytown NY) Lombardo Andrew T. (Bronx NY) Vink Walter (Purdys Station NY), Compressed chewable antacid tablet and method for forming same.
  4. Portenhauser Rudolf (Tutzing DEX) Bartl Knut (Wilzhofen DEX), Control or calibration serum for lipid diagnosis.
  5. Bonderman Ruby P. (Noblesville IN), Diagnostic and therapeutic compositions.
  6. Roser Bruce J. (Cambridgeshire GB3), Dried food containing trehalose and method for preparing same.
  7. Murphy Richard T. (Belle Mead NJ) Bergmann Wolfgang R. (Princeton NJ), Encapsulated co-micronized bicarbonate salt compositions.
  8. Cleland Jeffrey L. (San Carlos CA) Jones Andrew J. S. (San Mateo CA), Excipient stabilization of polypeptides treated with organic solvents.
  9. McCarty John A. (Biscayne Park FL), Fast dissolving buccal tablet.
  10. Makino Tadashi (Ibaraki JPX) Yamada Masayuki (Kawanishi JPX) Kikuta Jun-ichi (Suita JPX), Fast dissolving tablet and its production.
  11. Samuels W. D. (Richland WA) Exarhos Gregory J. (Richland WA), Glass/polymer composites and methods of making.
  12. Livesey Stephen A. (The Woodlands TX) Linner John G. (The Woodlands TX), Method for cryopreparing biological tissue.
  13. McHugh John E. (11633 S. Hawthorne Blvd. Hawthorne CA 90250), Method of forming an aqueous solution of 3-3-Bis(p-hydroxyphenyl)-phthalide.
  14. Wettlaufer Scott H. (Newfield NY) Leopold Aldo C. (Ithaca NY), Method of protecting biological materials from destructive reactions in the dry state.
  15. Goodrich ; Jr. Raymond P. (Pasadena CA) Williams Christine M. (Pasadena CA), Method of reconstituting lyophilized cells.
  16. Zema Marco (Como ITX) Mapelli Luigi G. (Milan ITX) Marconi Marco G. (Milan ITX), Pharmaceutical composition for rapid suspension in water.
  17. Johnson Eric A. (Madison WI) Goodnough Michael C. (Madison WI), Pharmaceutical composition of botulinum neurotoxin and method of preparation.
  18. Roser Bruce J. (Balsham GB3), Preservation of viruses.
  19. Louderback Allan L. (Temple City CA), Process for preparing a biological composition for use as a reference control in diagnostic analysis.
  20. Roser Bruce J. (Balsham GB3), Protection of proteins and the like.
  21. Hoskins Michael K. (Irvine CA), Stabilized isoenzyme control products.
  22. Li Mutti ; Charles M. ; Wu ; Tai-Wing ; Lynn ; Shirley Y., Stabilizers for reconstituted, lyophilized samples.
  23. Bollin ; Jr. Ernest (Bear DE) Fletcher Mark G. (Hartlend WI), Trehalose as stabilizer and tableting excipient.
  24. Bollin ; Jr. Ernest (Bear DE) Fletcher Mark G. (New Castle DE), Trehalose as stabilizer and tableting excipient.

이 특허를 인용한 특허 (62)

  1. Jacobi, Henrik Hugo; Lundegaard, Annette R.; Houghton, Christian Gauguin; Aasmul-Olsen, Stig; Maerkedahl, Lise Lund; Andersen, Jan Sondergaard; Mallindine, Kerry; Murray, Owen James; Banbury, Susan Gerrard; Wong, Desmond Yik Teng; Garrett, Lisa Marie; Hall, Michael, Allergen dosage form.
  2. Jacobi, Henrik Hugo; Lundegaard, Annette Roemmelmayer; Houghton, Christian Gauguin; Aasmul-Olsen, Stig; Maerkedahl, Lise Lund; Andersen, Jan Sondergaard, Allergen dosage form.
  3. Jacobi, Henrik Hugo; Lundegaard, Annette Roemmelmayer; Houghton, Christian Gauguin; Aasmul-Olsen, Stig; Maerkedahl, Lise Lund; Andersen, Jan Sondergaard; Mallindine, Kerry; Murray, Owen James; Banbury, Susan Gerrard; Wong, Desmond Yik Teng; Garrett, Lisa Marie; Hall, Michael, Allergen dosage form.
  4. Jacobi, Henrik Hugo; Lundegaard, Annette Roemmelmayer; Houghton, Christian Gauguin; Aasmul-Olsen, Stig; Maerkedahl, Lise Lund; Andersen, Jan Sondergaard; Mallindine, Kerry; Murray, Owen James; Banbury, Susan Gerrard; Wong, Desmond Yik Teng; Garrett, Lisa Marie; Hall, Michael, Allergen dosage form.
  5. Oku, Kazuyuki; Kubota, Michio; Fukuda, Shigeharu; Miyake, Toshio, Association compound of trehalose or maltitol with metal ion compound.
  6. Dam, Anders; Major, Janos; Tasco, Peter, Buccal drug delivery.
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  8. Dam, Anders; Major, Janos; Tasko, Peter, Buccal drug delivery.
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  12. Aldritt,Mary; Wehling,Fred; Lee,Robert E., Effervescent composition and method of making an effervescent composition including a viscous component.
  13. Venkatesh, Gopi M.; Vishnupad, Krishna S.; Percel, Phillip J., Extended release dosage forms of propranolol hydrochloride.
  14. Abu-Izza, Khawla A.; Li, Vincent H.; Look, Jee L.; Parr, Graham D.; Schineller, Matthew K., Fast dissolving tablet.
  15. Szamosi, Janos; Kinter, Kevin S.; Li, Vincent H.; Abu-Izza, Khawla Abdullah, Fast dissolving tablet.
  16. Mapelli, Luigi; Fabiani, Flavio; Boltri, Luigi; Gatti, Paolo; Serratoni, Mauro; Cassanmagnago, Roberto, Fexofenadine microcapsules and compositions containing them.
  17. Mapelli, Luigi; Fabiani, Flavio; Boltri, Luigi; Gatti, Paolo; Serratoni, Mauro; Cassanmagnago, Roberto, Fexofenadine microcapsules and compositions containing them.
  18. Mapelli, Luigi; Fabiani, Flavio; Boltri, Luigi; Gatti, Paolo; Serratoni, Mauro; Cassanmagnago, Roberto, Fexofenadine microcapsules and compositions containing them.
  19. Fu, Yourong; Pai, Chaul Min; Park, Sang Yeob; Seomoon, Gun; Park, Kinam, Highly plastic granules for making fast melting tablets.
  20. Ohta, Motohiro; Hayakawa, Eiji; Ito, Kunio; Tokuno, Sanji; Morimoto, Kiyoshi; Watanabe, Yasushi, Intrabuccally rapidly disintegrating tablet and a production method of the tablets.
  21. Ohta, Motohiro; Hayakawa, Eiji; Ito, Kunio; Tokuno, Sanji; Morimoto, Kiyoshi; Watanabe, Yasushi, Intrabuccally rapidly disintegrating tablet and a production method of the tablets.
  22. Ohta, Motohiro; Hayakawa, Eiji; Ito, Kunio; Tokuno, Sanji; Morimoto, Kiyoshi; Watanabe, Yasushi, Intrabuccally rapidly disintegrating tablet and a production method of the tablets.
  23. Bernstein, Howard; Chickering, Donald; Khattak, Sarwat; Straub, Julie, Matrices formed of polymer and hydrophobic compounds for use in drug delivery.
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  26. Bernstein,Howard; Chickering,Donald; Khattak,Sarwat; Straub,Julie, Matrices formed of polymer and hydrophobic compounds for use in drug delivery.
  27. Huang, Shihai X.; Phillips, Laurence; Lefebvre, Phillip, Medium used for blood sample collection and transport.
  28. Coffee, Ronald Alan; Pirrie, Alastair Bruce; Davies, David Neville, Method and apparatus for manufacturing dissolvable tablets.
  29. Buch-Rasmussen, Thomas; Aasmul, S.o slashed.ren; Flink, James M.; Hansen, Philip; Juul-Mortensen, Claus; Poulsen, Jens-Ulrik, Method for producing an elongated drug formation.
  30. Sparks, Robert E.; Jacobs, Irwin C.; Mason, Norbert S., Method of producing porous tablets with improved dissolution properties.
  31. Oberegger, Werner; Eradiri, Okponanabofa; Zhou, Fang; Maes, Paul, Modified release tablet of bupropion hydrochloride.
  32. Venkatesh, Gopi M.; Harmon, Troy M.; Taylor, John, Orally disintegrating tablets of atomoxetine.
  33. Pettersson, Anders; Nystrom, Christer, Pharmaceutical composition for the treatment of acute disorders.
  34. Pettersson, Anders; Nystrom, Christer, Pharmaceutical composition for the treatment of acute disorders.
  35. Julie Straub ; Howard Bernstein ; Donald E. Chickering, III ; Sarwat Khattak ; Greg Randall, Porous drug matrices and methods of manufacture thereof.
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  39. Straub,Julie A.; Bernstein,Howard; Chickering, III,Donald E.; Khattak,Sarwat; Randall,Greg, Porous paclitaxel matrices and methods of manufacture thereof.
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  53. Kampinga, Jaap, Stable particle in liquid formulations.
  54. Venkatesh, Gopi M., Taste-masked pharmaceutical compositions.
  55. Venkatesh, Gopi M., Taste-masked pharmaceutical compositions.
  56. Venkatesh, Gopi M., Timed, pulsatile release systems.
  57. Venkatesh, Gopi M., Timed, pulsatile release systems.
  58. Venkatesh, Gopi M., Timed, pulsatile release systems.
  59. Venkatesh, Gopi M., Timed, pulsatile release systems.
  60. Venkatesh, Gopi M., Timed, pulsatile release systems.
  61. Percel, Phillip J.; Vishnupad, Krishna S.; Venkatesh, Gopi M., Timed, sustained release systems for propranolol.
  62. Percel, Phillip J.; Vishnupad, Krishna S.; Venkatesh, Gopi M., Timed, sustained release systems for propranolol.
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