초록 ▼

Disclosed are methods, compositions and devices for use in transferring nucleic acids into bone cells in situ. The transfer of an osteotropic gene into bone progenitor cells is described, which event is shown to stimulate the progenitor cells and to promote bone growth, repair and regeneration in vi

Disclosed are methods, compositions and devices for use in transferring nucleic acids into bone cells in situ. The transfer of an osteotropic gene into bone progenitor cells is described, which event is shown to stimulate the progenitor cells and to promote bone growth, repair and regeneration in vivo. These gene transfer protocols are suitable for use in transferring various nucleic acid materials into bone, and have many uses, for example, in treating various bone-related diseases and defects, such as, in promoting fracture repair, use in connection with implants, and in treating osteoporosis and osteogenesis imperfecta.

대표청구항 ▼

[ What is claimed is:] [1.] A method for transferring a nucleic acid segment into bone progenitor cells located within a bone progenitor tissue site of an animal, comprising contacting said tissue site with a composition comprising a nucleic acid segment and a structural bone-compatible matrix so as

[ What is claimed is:] [1.] A method for transferring a nucleic acid segment into bone progenitor cells located within a bone progenitor tissue site of an animal, comprising contacting said tissue site with a composition comprising a nucleic acid segment and a structural bone-compatible matrix so as to transfer said nucleic acid segment into said cells, wherein said nucleic acid segment expresses a transcriptional or translational product in said cells.