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Stabilized pharmaceutical 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A01N-037/18
  • A61K-031/165
출원번호 US-0667239 (1996-06-21)
우선권정보 GB-0015856 (1993-07-30)
발명자 / 주소
  • Ruff Michael D.
  • Kalidindi Sanvasi R.
  • Sutton
  • Jr. Joel Elmore
출원인 / 주소
  • Glaxo Wellcome Inc.
대리인 / 주소
    Makujina
인용정보 피인용 횟수 : 58  인용 특허 : 18

초록

This application discloses a method of inhibiting degradation of the antidepressant bupropion hydrochloride in a solid pharmaceutical formulation, so that the pharmaceutical formulation will maintain at least 80% of its initial bupropion potency after one year.

대표청구항 ▼

[ We claim:] [1.] A pharmaceutical composition in solid form comprising bupropion hydrochloride and a pharmaceutically acceptable stabiliser in an effective stabilising amount, in which the composition contains at least about 80% w/w of undegraded bupropion hydrochloride after storage for 6 weeks at

이 특허에 인용된 특허 (18)

  1. Scharver Jeffrey D. (Durham NC), 3H Labeled compounds.
    상세보기
  2. Peck Anthony W. (Bromley GB2), Benzodiazepine tranquilizer combinations and the use thereof.
    상세보기
  3. Peck Anthony W. (Bromley GB2), Bupropion and ethanol.
    상세보기
  4. Findlay John W. A. (Chapel Hill NC) Butz Robert F. (Durham NC) Welch Richard M. (Raleigh NC), Bupropion radioimmunoassay, and kit.
    상세보기
  5. Findlay John W. A. (Chapel Hill NC) Butz Robert F. (Durham NC) Welch Richard M. (Raleigh NC), Compounds and methods of making.
    상세보기
  6. Mehta Nariman B. (Raleigh NC), Compounds and methods of making same.
    상세보기
  7. Phillips Arthur P. (Raleigh NC), Compounds and methods of making them.
    상세보기
  8. Baker Richard W. (Mountain View CA) Smith Kelly L. (Bend OR) Brooke James W. (Sisters OR), Delivery system.
    상세보기
  9. Peck Anthony W. (Bromley GB2), Lorazepam and bupropion, compositions and methods.
    상세보기
  10. Ruff Michael D. (Greenville NC) Kalidindi Sanyasi R. (Edison NJ) Sutton ; Jr. Joel E. (Greenville NC), Pharmaceutical composition containing bupropion hydrochloride and a stabilizer.
    상세보기
  11. Baker Richard W. (Mountain View CA) Brooke James W. (Sisters OR), Pharmaceutical delivery system.
    상세보기
  12. Baker Richard W. (Palo Alto CA) Brooke James W. (Sisters OR), Pharmaceutical delivery system.
    상세보기
  13. Stern Warren C. (Raleigh NC), Prolactin suppression in mammals.
    상세보기
  14. Findlay John W. A. (Chapel Hill NC) Butz Robert F. (Durham NC) Welch Richard M. (Raleigh NC), Radioactive nuclide labeled propiophenone compounds.
    상세보기
  15. Stern Warren C. (Raleigh NC), Reduction of cholesterol with meta-chloro a 상세보기
  • Stern Warren C. (Raleigh NC), Treatment of minimal brain dysfunction (MBD).
    상세보기
  • Stern Warren C. (Raleigh NC), Treatment of psychosexual dysfunctions.
    상세보기
  • Stern Warren C. (Raleigh NC), Treatment of tardive dyskinesia in mammals.
    상세보기

    • 이 특허를 인용한 특허 (58)

    1. Sanganabhatla, Shankar; Soni, Vijay; Khan, Mubeen Ahmed; Agarwal, Nandlal; Kamble, Hemanth; Gore, Sharad, Amorphous bupropion hydrobromide and preparation thereof.
      상세보기
    2. Midha Kamal K.,BMX ; Junginer Hans E.,NLX ; Hirsh Mark, Apparatus and method for transdermal delivery of bupropion.
      상세보기
    3. Qun Kevin Fang ; Chrisantha Hugh Senanayake ; Paul Grover, Bupropion metabolites and methods of use.
      상세보기
    4. Thomas P. Jerussi ; John R. McCullough ; Chrisantha H. Senanayake ; Qun K. Fang, Bupropion metabolites and methods of use.
      상세보기
    5. Cowley, Michael A.; McKinney, Anthony A.; Tollefson, Gary, Compositions and methods for increasing insulin sensitivity.
      상세보기
    6. Cowley, Michael A.; McKinney, Anthony A.; Tollefson, Gary, Compositions and methods for increasing insulin sensitivity.
      상세보기
    7. Gjorstrup, Per; Schwartz, C. Eric, Compositions and methods for the treatment of inflammation.
      상세보기
    8. Gjorstrup, Per; Schwartz, C. Eric, Compositions and methods for the treatment of inflammation.
      상세보기
    9. Weber, Eckard; Cowley, Michael Alexander, Compositions for affecting weight loss.
      상세보기
    10. Weber,Eckard; Cowley,Michael Alexander, Compositions for affecting weight loss.
      상세보기
    11. Weber,Eckard; Cowley,Michael Alexander, Compositions for affecting weight loss.
      상세보기
    12. Gadde,Kishore M.; Krishnan,K. Ranga R., Compositions of an anticonvulsant and an antipsychotic drug and methods of using the same for affecting weight loss.
      상세보기
    13. Krishnan, K. Ranga R.; Gadde, Kishore M., Compositions of an anticonvulsant and mirtazapine to prevent weight gain.
      상세보기
    14. Chen Chih-Ming ; Xie Jianbo ; Jan Steve, Controlled release bupropion formulation.
      상세보기
    15. Li, Boyong; Nangia, Avinash; Chen, Chih Ming; Cheng, Xiu Xiu, Controlled release oral dosage form.
      상세보기
    16. Li, Boyong; Nangia, Avinash; Chen, Chih Ming; Cheng, Xiu Xiu, Controlled release oral dosage form.
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    17. Li, Boyong; Nangia, Avinash; Chen, Chih Ming; Cheng, Xiu Xiu, Controlled release oral dosage form.
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    18. Li, Boyong; Nangia, Avinash; Chen, Chih Ming; Cheng, Xiu Xiu, Controlled release oral dosage form.
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    19. Zerbe, Horst G.; Paiement, Nadine, Controlled-release pharmaceutical tablets.
      상세보기
    20. Lee, Hun Joo; Lim, Jung Youl; Jung, Yong Woo; Lim, Bum Hyun; Shim, Kwang Hyun; Choi, Jin Sung; Yang, Kwang Ho; Kim, Hyun Bin, Database cache system.
      상세보기
    21. Koong, Albert C.; Feldman, Douglas E., Inhibitors of the unfolded protein response and methods for their use.
      상세보기
    22. McKinney, Anthony; Tollefson, Gary; Weber, Eckard; Soltero, Rick, Layered pharmaceutical formulations.
      상세보기
    23. McKinney, Anthony; Tollefson, Gary; Weber, Eckard; Soltero, Rick, Layered pharmaceutical formulations.
      상세보기
    24. James W. Young, Method for treating depression using optically pure (-)-bupropion.
      상세보기
    25. Gadde, Kishore M.; Krishnan, K. Ranga R., Method for treating obesity.
      상세보기
    26. Gadde,Kishore M.; Krishnan,K. Ranga R., Method for treating obesity.
      상세보기
    27. John R. McCullough ; Paul D. Rubin, Methods and compositions for aiding in smoking cessation and for treating pain and other disorders using optically pure (+)-bupropion.
      상세보기
    28. John R. McCullough ; Paul D. Rubin, Methods and compositions for treating chronic disorders using optically pure (+)-bupropion.
      상세보기
    29. Kumar Vijai ; McGuffy Kevin Scott, Methods and formulations for making bupropion hydrochloride tablets using direct compression.
      상세보기
    30. Chow, San-Laung; Wong, David; Garcia, Damian, Methods and formulations for making pharmaceutical compositions containing bupropion.
      상세보기
    31. McKinney, Anthony A.; Tollefson, Gary; Weber, Eckard; Soltero, Rick, Methods for administering weight loss medications.
      상세보기
    32. McKinney, Anthony; Tollefson, Gary; Weber, Eckard; Soltero, Rick, Methods for administering weight loss medications.
      상세보기
    33. Young James W., Methods for treating Parkinson's disease using optically pure (-)-bupropion.
      상세보기
    34. James W. Young, Methods for treating depression and other disorders using optically pure (-)-bupropion.
      상세보기
    35. Young James W., Methods for treating obesity and weight gain using optically pure (-)-bupropion.
      상세보기
    36. Dunayevich, Eduardo; Tollefson, Gary, Methods of providing weight loss therapy in patients with major depression.
      상세보기
    37. Jonas, Jeffrey; Bose, Anjana; Tsai, Joyce, Methods of treating central nervous system disorders with a low dose combination of escitalopram and bupropion.
      상세보기
    38. Klassen, Preston; Taylor, Kristin, Methods of treating overweight and obesity.
      상세보기
    39. Wennogle, Lawrence P., Methods of treating vasomotor symptoms.
      상세보기
    40. Oberegger, Werner; Maes, Paul; Jackson, Graham; Saleh, Mohammad Ashty, Modified release formulations of a bupropion salt.
      상세보기
    41. Oberegger, Werner; Zhou, Fang; Maes, Paul; Jackson, Graham; Saleh, Mohammad Ashty, Modified release formulations of a bupropion salt.
      상세보기
    42. Oberegger, Werner; Zhou, Fang; Maes, Paul; Jackson, Graham; Saleh, Mohammad Ashty, Modified release formulations of a bupropion salt.
      상세보기
    43. Oberegger, Werner; Zhou, Fang; Maes, Paul; Turchetta, Stefano; Jackson, Graham; Massardo, Pietro; Saleh, Mohammad Ashty, Modified release formulations of a bupropion salt.
      상세보기
    44. Oberegger, Werner; Eradiri, Okponanabofa; Zhou, Fang; Maes, Paul, Modified release tablet of bupropion hydrochloride.
      상세보기
    45. Ascher,John A.; Johnston,Joseph Andrews; Learned Coughlin,Susan Marie; Bye,Alan, Pharmaceutically active morpholinol.
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    46. Broom, Toby; Delpogetto, Monica; Atkins, Richard; Negus, Alan; Oxley, Paul William, Pharmaceutically active morpholinol.
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    47. Musso,David Lee, Pharmaceutically active morpholinol.
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    48. Partridge, John Joseph, Pharmaceutically active morpholinol.
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    49. Zerbe, Horst; Paiement, Nadine; Angusti, Angela; Long, Cormac, Solid oral film dosage forms and methods for making same.
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    50. Apelian Vahe Henry ; Parikh Nilesh H. ; Iyer Raman, Stabilized pharmaceutical compositions.
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    51. Chungi Shubha ; Lin Kangwen, Stabilized, acid-free formulation for sustained release of bupropion hydrochloride.
      상세보기
    52. Li, Boyong; Cheng, Xiu Xiu, Stable pharmaceutical compositions without a stabilizer.
      상세보기
    53. Li, Boyong; Cheng, Xiu Xiu, Stable pharmaceutical compositions without a stabilizer.
      상세보기
    54. Giaccia, Amato; Lai, Edwin; Razorenova, Olga; Chan, Denise; Hay, Michael Patrick; Bonnet, Muriel; Sun, Connie; Tabibiazar, Ray; Yuen, Po-wai, Substituted benzamides and their uses.
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    55. Giaccia, Amato; Lai, Edwin; Razorenova, Olga; Chan, Denise; Hay, Michael Patrick; Bonnet, Muriel; Sun, Connie; Tabibiazar, Ray; Yuen, Po-wai, Substituted benzamides and their uses.
      상세보기
    56. McKinney, Anthony A.; Tollefson, Gary D.; Soltero, Richard; Dunzo, Thea Elise, Sustained release formulation of naltrexone.
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    57. McKinney, Anthony A.; Tollefson, Gary D.; Soltero, Richard; Dunzo, Thea Elise, Sustained release formulation of naltrexone.
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    58. Zerbe, Horst G.; Paiement, Nadine, Sustained-release bupropion and bupropion/mecamylamine tablets.
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