Peptides and compounds that bind to the IL-1 receptor
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-038/00
C07K-005/00
C07K-007/00
출원번호
US-0383474
(1995-02-01)
발명자
/ 주소
Yanofsky Stephen D.
Barrett Ronald W.
Baldwin David
Jacobs Jeff W.
출원인 / 주소
Affymax Technologies, N.V., GBX
대리인 / 주소
Murphy
인용정보
피인용 횟수 :
46인용 특허 :
0
초록▼
Peptides that bind to the interleukin-1 type I receptor (IL-1RtI) can be used to assay the amount of IL-1R, or an IL-1R agonist or antagonist, in a sample and comprise a sequence of amino acids selected from the group consisting of (1) WXXXGZ.sub.1 W (SEQ ID NO: 2) where Z.sub.1 is L, I, A, or Q; (2
Peptides that bind to the interleukin-1 type I receptor (IL-1RtI) can be used to assay the amount of IL-1R, or an IL-1R agonist or antagonist, in a sample and comprise a sequence of amino acids selected from the group consisting of (1) WXXXGZ.sub.1 W (SEQ ID NO: 2) where Z.sub.1 is L, I, A, or Q; (2) XXQZ.sub.5 YZ.sub.6 XX where (SEQ ID NO: 1) Z.sub.5 is P or Aze where Aze is azetidine; and Z.sub.6 is S, A, V, or L; and (3) Z.sub.23 NZ.sub.24 SZ.sub.25 Z.sub.26 Z.sub.27 Z.sub.28 Z.sub.29 Z.sub.30 L (SEQ ID NO: 313) where Z.sub.23 is D or Y; Z.sub.24 is D or S; Z.sub.25 is S or W; Z.sub.26 is S or Y; Z.sub.27 is D or V; Z.sub.28 is S or W; Z.sub.29 is F or L; and Z.sub.30 is D or L; and where each amino acid is indicated by standard one letter abbreviation; and each X can be selected from any one of the 20 genetically coded L-amino acids or the stereoisomeric D-amino acids.
대표청구항▼
[ We claim:] [1.] A compound that binds to an interleukin-1 type I receptor, said compound comprisinga molecular weight less than about 3000 Daltons;a binding affinity to an interleukin-1 type I receptor as expressed by an IC.sub.50 standard of no more than about 2.5 mM; andwherein said binding of s
[ We claim:] [1.] A compound that binds to an interleukin-1 type I receptor, said compound comprisinga molecular weight less than about 3000 Daltons;a binding affinity to an interleukin-1 type I receptor as expressed by an IC.sub.50 standard of no more than about 2.5 mM; andwherein said binding of said compound to said interleukin-1 type I receptor is competitively inhibited by a peptide of eight to twenty-five amino acids in length, said peptide comprising a core sequence of amino acids Z.sub.7 Z.sub.8 QZ.sub.5 YZ.sub.6 Z.sub.9 Z.sub.10 (SEQ ID NO: 8) where Z.sub.5 is P or Aze where Aze is azetidine; Z.sub.6 is S, A, V, or L; Z.sub.7 is Y, W, or F; Z.sub.8 is E, F, V, W, or Y; Z.sub.9 is M, F, V, R, Q, K, T, S, D, L, I, or E; and Z.sub.10 is E, L, W, V, H, I, G, A, D, L, Y, N, Q or P.
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