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Cloning and exprssion of humanized monoclonal antibodies against human interluekin-4 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12P-021/04
  • C12N-015/00
  • C12N-001/20
  • C07H-021/04
출원번호 US-0469557 (1995-06-06)
발명자 / 주소
  • Dalie Barbara
  • Le Hung V.
  • Miller Kenneth
  • Murgolo Nicholas J.
  • Nguyen Hanh
  • Tindall Stephen
  • Zavodny Paul J.
출원인 / 주소
  • Schering Corporation
대리인 / 주소
    Dulak
인용정보 피인용 횟수 : 43  인용 특허 : 2

초록 ▼

Monoclonal antibodies are provided which are specific for human interleukin-4. Also provided are complementary DNAs which encode the heavy and light chain variable regions of such monoclonal antibodies and complementarity determining regions from such DNAs; and kits and methods for detecting, measur

대표청구항

[ What is claimed is:] [1.] A nucleic acid which encodes a humanized antibody which comprises a variable region having the amino acid sequence of an antibody, selected from the group consisting of h25D2L-1, h25D2hH-1, h25D2H-2, h25D2H-3, h252H-4, and h25D2H-5.

이 특허에 인용된 특허 (2)

  1. Queen Cary L. (Los Altos CA) Selick Harold E. (Belmont CA), Humanized immunoglobulins.
    상세보기
  2. Abrams John S. (Belmont CA) Chretien Isabelle (Ecully CA FRX) Lee Frank D. (Palo Alto CA), .
    상세보기

이 특허를 인용한 특허 (43)

  1. Rabuka, David; Albers, Aaron Edward; Barfield, Robyn M.; deHart, Gregory W.; Drake, Penelope M.; Kudirka, Romas Alvydas; Garofalo, Albert W.; McFarland, Jesse M., Anti-HER2 antibody-maytansine conjugates and methods of use thereof.
    상세보기
  2. Schreiber, Taylor H.; Hutchins, Jeff T., Anti-TNFRSF25 antibodies.
    상세보기
  3. Krumlauf, Robb; Ellies, Debra, Antibodies that specifcally bind Sost and Wise peptides.
    상세보기
  4. Yusibov, Vidadi; Mett, Vadim; Musiychuck, Konstantin; Skarjinskaia, Marina, Bacillus anthracis antigens, vaccine compositions, and related methods.
    상세보기
  5. Ramakrishnan,Vanitha; Powers,David; Johnson,Dale E.; Jeffry,Ursula; Bhaskar,Vinay, Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis.
    상세보기
  6. Ramakrishnan, Vanitha; Powers, David; Johnson, Dale E.; Jeffry, Ursula, Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis.
    상세보기
  7. Ramakrishnan, Vanitha; Powers, David; Johnson, Dale E.; Jeffry, Ursula; Bhaskar, Vinay, Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis.
    상세보기
  8. Ramakrishnan, Vanitha; Powers, David; Johnson, Dale E.; Jeffry, Ursula; Bhaskar, Vinay, Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis.
    상세보기
  9. Ramakrishnan, Vanitha; Powers, David; Johnson, Dale E.; Jeffry, Ursula; Bhaskar, Vinay, Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis.
    상세보기
  10. Ramakrishnan, Vanitha; Powers, David; Johnson, Dale E.; Jeffry, Ursula; Bhaskar, Vinay, Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis.
    상세보기
  11. Yusibov, Vidadi; Mett, Vadim; Hull, Anna, Compositions and methods for production of immunoglobulins.
    상세보기
  12. Kudirka, Romas Alvydas; Albers, Aaron Edward; Rabuka, David, Compounds and methods for producing a conjugate.
    상세보기
  13. Schreiber, Taylor H., Human TNFRSF25 antibody.
    상세보기
  14. Yusibov, Vidadi; Mett, Vadim; Shoji, Yoko, Humanized neuraminidase antibody and methods of use thereof.
    상세보기
  15. Yusibov, Vidadi; Mett, Vadim; Shoji, Yoko, Humanized neuraminidase antibody and methods of use thereof.
    상세보기
  16. Kudirka, Romas Alvydas; Albers, Aaron Edward; Barfield, Robyn M.; Rabuka, David, Hydrazinyl-indole compounds and methods for producing a conjugate.
    상세보기
  17. Kudirka, Romas Alvydas; Albers, Aaron Edward; Barfield, Robyn M.; Rabuka, David, Hydrazinyl-indole compounds and methods for producing a conjugate.
    상세보기
  18. Rabuka, David; Albers, Aaron Edward; Kudirka, Romas Alvydas; Garofalo, Albert W., Hydrazinyl-pyrrolo compounds and methods for producing a conjugate.
    상세보기
  19. Yusibov, Vidadi; Mett, Vadim; Musiychuck, Konstantin, Influenza antigens, vaccine compositions, and related methods.
    상세보기
  20. Yusibov, Vidadi; Mett, Vadim; Chichester, Jessica; Goldschmidt, Lauren, Influenza hemagglutinin antibodies, compositions and related methods.
    상세보기
  21. Yusibov, Vidadi; Mett, Vadim; Chichester, Jessica; Goldschmidt, Lauren, Influenza hemagglutinin antibodies, compositions and related methods.
    상세보기
  22. Dong, Haidong; Kwon, Eugene D.; Markovic, Svetomir N.; Krco, Christopher J., Methods and materials for treating cancer.
    상세보기
  23. Dong, Haidong; Harrington, Susan M.; Kwon, Eugene D.; Krco, Christopher J.; Liu, Xin, Methods for treating cancer in patients with elevated levels of BIM.
    상세보기
  24. Ellies, Debra L., Methods of altering bone growth by administration of sost or wise antagonist or agonist.
    상세보기
  25. Ellies, Debra L., Methods of altering bone growth by administration of sost or wise antagonist or agonist.
    상세보기
  26. Bertozzi, Carolyn; Agarwal, Paresh; Sletten, Ellen M., Pictet-Spengler ligation for protein chemical modification.
    상세보기
  27. Yusibov, Vidadi; Mett, Vadim; Rabindran, Shailaja; Shamloul, Moneim; Ensley, Burt, Production of foreign nucleic acids and polypeptides in sprout systems.
    상세보기
  28. Ensley, Burt D.; Yusibov, Vidadi, Production of pharmaceutically active proteins in sprouted seedlings.
    상세보기
  29. Holmes, Stephen Dudley; Gross, Mitchell Stuart; Sylvester, Daniel R., Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders.
    상세보기
  30. Yusibov, Vidadi; Mett, Vadim; Musiychuk, Konstantin, Recombinant carrier molecule for expression, delivery and purification of target polypeptides.
    상세보기
  31. Yusibov, Vidadi; Mett, Vadim; Musiychuk, Konstantin, Recombinant carrier molecule for expression, delivery and purification of target polypeptides.
    상세보기
  32. Yusibov, Vidadi; Mett, Vadim; Musiychuk, Konstantin, Recombinant carrier molecule for expression, delivery and purification of target polypeptides.
    상세보기
  33. Zheng, Sheng Jia; Angel, Mathew Doyle; Amin, Ziad Mohamed; Hallak, Mahdi, System and method for controlling pitch angle of a wind turbine rotor blade.
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  34. Fedorkin, Oleg; Rabindran, Shailaja; Yusibov, Vidadi, System for expression of genes in plants.
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  35. Fedorkin, Oleg; Rabindran, Shailaja; Yusibov, Vidadi, System for expression of genes in plants.
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  36. Fedorkin, Oleg; Rabindran, Shailaja; Yusibov, Vidadi, System for expression of genes in plants.
    상세보기
  37. Fedorkin, Oleg; Rabindran, Shailaja; Yusibov, Vidadi, System for expression of genes in plants.
    상세보기
  38. Fedorkin, Oleg; Rabindran, Shailaja; Yusibov, Vidadi, System for expression of genes in plants.
    상세보기
  39. Yusibov, Vidadi; Skarjinskaia, Marina, Systems and methods for clonal expression in plants.
    상세보기
  40. Knapp, Elisabeth; Yusibov, Vidadi, Trypanosoma antigens, vaccine compositions, and related methods.
    상세보기
  41. Ramakrishnan, Vanitha; Bhaskar, Vinay; Ho, Sun; Murray, Richard; Law, Debbie, Use of anti-α5β1 antibodies to inhibit cancer cell proliferation.
    상세보기
  42. Yusibov, Vidadi; Mett, Vadim; Musiychuk, Konstantin, Yersinia pestis antigens, vaccine compositions, and related methods.
    상세보기
  43. Yusibov, Vidadi; Mett, Vadim; Musiychuk, Konstantin, Yersinia pestis antigens, vaccine compositions, and related methods.
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