초록 ▼

A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. In one particular embodiment, an array of rotated cyclic polymers

A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. In one particular embodiment, an array of rotated cyclic polymers is formed. In another embodiment, an array of polymers is formed based on a target polymer. The array includes systematically substituted versions of the target molecule. In another embodiment, rotated and systematically substituted cyclic polymers are formed on a substrate.

대표청구항 ▼

[ What is claimed is:] [1.] An array of cyclic nucleic acids on a substrate, said nucleic acids having N nucleotide positions, said substrate comprising N different sites, said substrate sites comprising said cyclic nucleic acids coupled thereto, said cyclic nucleic acids comprising common nucleotid

[ What is claimed is:] [1.] An array of cyclic nucleic acids on a substrate, said nucleic acids having N nucleotide positions, said substrate comprising N different sites, said substrate sites comprising said cyclic nucleic acids coupled thereto, said cyclic nucleic acids comprising common nucleotide sequences but coupled to said substrate at a different one of said nucleotide positions via a tether molecule in each of said different substrate sites. [5.] An array of cyclic polypeptides on a substrate, said polypeptides having N amino acid positions, said substrate comprising N different sites, said substrate sites comprising said cyclic polypeptides coupled thereto, said cyclic polypeptides comprising common amino acid sequences but coupled to said substrate at a different one of said amino acid positions via a tether molecule in each of said different substrate sites.