초록

Autologous fibrinogen and chitosan containing hemostatic adhesive agents having strong hemostatic properties when applied to a bleeding wound or vessel. Fibrinogen is isolated and purified using ammonium sulphate precipitation in slow incremental portions.

대표청구항 ▼

[ What is claimed is:] [1.] An improved hemostatic adhesive agent consisting essentially of a mixture of fibrinogen isolated from plasma and purified of other plasma proteins and a biocompatible chitosan polymer,wherein a ratio of the chitosan polymer to the isolated and purified fibrinogen is from

[ What is claimed is:] [1.] An improved hemostatic adhesive agent consisting essentially of a mixture of fibrinogen isolated from plasma and purified of other plasma proteins and a biocompatible chitosan polymer,wherein a ratio of the chitosan polymer to the isolated and purified fibrinogen is from about 0.1:10% to about 90:99.9%, w/w, andwherein said fibrinogen is separated from other plasma proteins by precipitation with ammonium sulfate solution having concentration of about 65-73 g per 100 ml, said precipitation comprising the addition of about 10 ml of said ammonium sulfate solution to about 40 ml of plasma continuously in increments from about 0.50 to about 0.62 ml per minute for about 15-20 minutes.