초록 ▼

Polymers are provided comprising protein polymers comprising blocks of repeating units and sequences comprising amino acids, individually or in defined sequences, capable of enzyme catalyzed covalent bond formation for cross-linking, as exemplified by glutamine and/or lysine reactive for FXIII catal

Polymers are provided comprising protein polymers comprising blocks of repeating units and sequences comprising amino acids, individually or in defined sequences, capable of enzyme catalyzed covalent bond formation for cross-linking, as exemplified by glutamine and/or lysine reactive for FXIII catalyzed isopeptide formation or non-amino acid polymers having side chains comprising such amino acids or sequences, which may be used for preparation of articles of manufacture, particularly cross-linkable compositions. By appropriate choice of the polymer, resorbable implantable polymers may be used in internal applications for mammals as formed objects or depots.

대표청구항 ▼

[ What is claimed is:] [1.] A recombinant protein polymer of a molecular weight in the range of 15 to 250 kD comprised of naturally occurring repetitive units from 3 to 18 amino acids and at least two enzyme recognition sequences separated by at least 25 intervening amino acids, said recognition seq

[ What is claimed is:] [1.] A recombinant protein polymer of a molecular weight in the range of 15 to 250 kD comprised of naturally occurring repetitive units from 3 to 18 amino acids and at least two enzyme recognition sequences separated by at least 25 intervening amino acids, said recognition sequences comprising a glutamine capable of enzyme catalyzed isopeptide formation.