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Methods of transcriptionally modulating gene expression

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12N-015/00
  • A61K-049/00
  • A61K-033/00
  • A61K-031/70
출원번호 US-0458691 (1995-06-02)
발명자 / 주소
  • Foulkes J. Gordon
  • Franco Robert
  • Leichtfried Franz
  • Pieler Christian
  • Stephenson John R.
출원인 / 주소
  • Oncogene Science, Inc.
대리인 / 주소
    White
인용정보 피인용 횟수 : 41  인용 특허 : 4

초록

The present invention provides a method of transcriptionally modulating the expression of a gene of interest, the expression of which is associated with a defined physiological or pathological effect within a multicellular organism. The method comprises contacting a cell which is capable of expressi

대표청구항

[ What is claimed is:] [1.] A method for transcriptionally modulating the expression of a gene of interest in a multicellular organism which comprises administering to said organism an amount of a molecule effective to modulate transcription of the gene of interest,wherein said gene of interest is o

이 특허에 인용된 특허 (4)

  1. Barton Jacqueline K. (New York NY), Chemical probes for left-handed DNA and chiral metal complexes as Z-specific anti-tumor agents.
  2. Gordon Robert T. (4936 W. Estes Skokie IL 60077), Method for affecting intracellular and extracellular electric and magnetic dipoles.
  3. Hewitt Charles W. (698 Tranquility Turn Marlton NJ 08053) Black Kirby S. (13401 Sussex Pl. Santa Ana CA 92705), Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants.
  4. Barton Jacqueline K. (New York NY), Site-specific chiral ruthenium (II) and cobalt (III) antitumor agents.

이 특허를 인용한 특허 (41)

  1. Gao Guang-Ping ; Wilson James M., Adenovirus gene therapy vehicle and cell line.
  2. Cook, Phillip Dan; Sanghvi, Yogesh Shantilal; Vasseur, Jean Jacques; Debart, Francoise, Backbone modified oligonucleotide analogues.
  3. Gong, Xianchang; Barrett, Kathy; Cao, Jianguo; Gritzen, Colleen; Noronha, Glenn; Hood, John D.; Mak, Chi Ching; McPherson, Andrew; Pathak, Ved Prakash; Renick, Joel; Soll, Richard M.; Splittgerber, Ute; Wrasidlo, Wolfgang; Zeng, Binqi; Zhao, Ningning; Dneprovskaia, Elena, Benzotriazine inhibitors of kinases.
  4. Noronha,Glenn; Barrett,Kathy; Cao,Jianguo; Gritzen,Colleen; Gong,Xianchang; Hood,John D.; Mak,Chi Ching; McPherson,Andrew; Pathak,Ved Prakash; Renick,Joel; Soll,Richard M.; Splittgerber,Ute; Wrasidlo,Wolfgang; Zeng,Binqi; Zhao,Ningning; Dneprovskaia,Elena, Benzotriazine inhibitors of kinases.
  5. Noronha, Glenn; Mak, Chi Ching; Cao, Jianguo; Renick, Joel; McPherson, Andrew; Zeng, Binqi; Pathak, Ved P.; Lohse, Daniel L.; Hood, John D.; Soll, Richard M., Bi-aryl meta-pyrimidine inhibitors of kinases.
  6. Noronha, Glenn; Mak, Chi Ching; Cao, Jianguo; Renick, Joel; McPherson, Andrew; Zeng, Binqi; Pathak, Ved P.; Lohse, Daniel L.; Hood, John D.; Soll, Richard M., Bi-aryl meta-pyrimidine inhibitors of kinases.
  7. Noronha, Glenn; Mak, Chi Ching; Cao, Jianguo; Renick, Joel; McPherson, Andrew; Zeng, Binqi; Pathak, Ved P.; Lohse, Daniel L.; Hood, John D.; Soll, Richard M., Bi-aryl meta-pyrimidine inhibitors of kinases.
  8. Wrasidlo, Wolfgang; Dneprovskaia, Elena, Heterocyclic compounds and methods of use.
  9. Stylli, Chari; Beckey, Samuel S.; Shumate, Christopher Bentley; Coassin, Peter J., High throughput chemical handling system.
  10. Doukas, John; Mak, Chi Ching; Dneprovskaia, Elena; Noronha, Glenn, Kinase inhibitors and methods of use thereof.
  11. Christopher Bentley Shumate ; Peter J. Coassin, Liquid chemical distribution method and apparatus.
  12. Shumate,Christopher Bentley; Coassin,Peter J., Liquid chemical distribution method and apparatus.
  13. Tony Giordano ; Deborah L. Beach ; Gretchen L. Temeles, Method for identifying compounds RNA/RNA binding protein interactions.
  14. Conkling,Mark A.; Song,Wen; Mendu,Nandini, Methods and compositions for protein production in tobacco plants with reduced nicotine.
  15. Clawson, Gary A.; Pan, Wei-Hua; Thiboutot, Diane; Christensen, Neil, Methods and materials for treating human papillomavirus infections.
  16. Stylli, Chari; Beckey, Samuel S.; Shumate, Christopher Bentley; Coassin, Peter J., Methods for rapidly identifying useful chemicals in liquid sample.
  17. Foulkes J. Gordon ; Leichtfried Franz ; Pieler Christian ; Stephenson John R., Methods of specifically transcriptionally modulating the expression of gene of interest.
  18. Foulkes J. Gordon ; Leichtfried Franz E. ; Pieler Christian ; Stephenson John R. ; Case Casey C., Methods of transcriptionally modulating expression of viral genes and genes useful for production of proteins.
  19. Conkling, Mark A., Modifying nicotine and nitrosamine levels in tobacco.
  20. Bitter Grant A., Phenotypic assays of cyclin/cyclin-dependent kinase function.
  21. Conkling,Mark A.; Li,Yan, Plant promoter sequence.
  22. Conkling, Mark A.; Li, Yan, Promoter fragment that is recognized by the product of the tobacco Nic gene.
  23. Kalin, Ned H.; Roseboom, Patrick H.; Landry, Charles F.; Nanda, Steven A., Promoter sequences for corticotropin releasing-factor receptor CRF2α and method of identifying agents that alter the activity of the promoter sequences.
  24. Kalin,Ned H.; Roseboom,Patrick H.; Landry,Charles F.; Nanda,Steven A., Promoter sequences for corticotropin releasing-factor receptor CRFand method of identifying agents that alter the activity of the promoter sequences.
  25. Conkling,Mark; Li,Yan, Putrescine-n-methyltransferase promoter.
  26. Oscar L. Acevedo ; Martin G. Dunkel DE; Phillip Dan Cook, Pyrimidine nucleosides.
  27. Conkling, Mark A.; Song, Wen; Mendu, Nandini, Regulation of quinolate phosphoribosyl transferase expression.
  28. Conkling,Mark A.; Song,Wen; Mendu,Nandini, Regulation of quinolate phosphoribosyl transferase expression.
  29. Conkling,Mark A.; Song,Wen; Mendu,Nandini, Regulation of quinolate phosphoribosyl transferase expression.
  30. Conkling, Mark A.; Song, Wen; Mendu, Nandini, Regulation of quinolate phosphoribosyl transferase expression by transformation with a tobacco quinolate phosphoribosyl transferase nucleic acid.
  31. Wu Jun ; Barbosa Miguel S. ; Suto Carla M., Reporter cell line system for detecting cytomegalovirus and identifying modulators of viral gene expression.
  32. Chari Stylli ; Samuel S. Beckey ; Christopher Bentley Shumate ; Peter J. Coassin, Systems and methods for rapidly identifying useful chemicals in liquid samples.
  33. Chari Stylli ; Samuel S. Beckey ; Christopher Bentley Shumate ; Peter J. Coassin, Systems and methods for rapidly identifying useful chemicals in liquid samples.
  34. Stylli Chari ; Beckey Samuel S. ; Shumate Christopher Bentley ; Coassin Peter J., Systems and methods for rapidly identifying useful chemicals in liquid samples.
  35. Stylli, Chari; Beckey, Samuel S.; Shumate, Christopher Bentley; Coassin, Peter J., Systems and methods for rapidly identifying useful chemicals in liquid samples.
  36. Norris, James; Clawson, Gary; Westwater, Caroline; Schofield, David; Schmidt, Michael G.; Hoel, Brian; Dolan, Joseph; Pan, Wei Hua, Tissue-specific and pathogen-specific ribozymes.
  37. Conkling, Mark A.; Song, Wen; Mendu, Nandini, Tobacco products with increased nicotine.
  38. Conkling, Mark A.; Song, Wen; Mendu, Nandini, Tobacco products with reduced nicotine.
  39. Hood, John D.; Noronha, Glenn, Use of bi-aryl meta-pyrimidine inhibitors of kinases.
  40. Noronha, Glenn; Hood, John D.; Soll, Richard M., Use of bi-aryl meta-pyrimidine inhibitors of kinases.
  41. Wrasidlo,Wolfgang; Doukas,John; Royston,Ivor; Noronha,Glenn; Hood,John D.; Dneprovskaia,Elena; Gong,Xianchang; Splittgerber,Ute; Zhao,Ningning, Vasculostatic agents and methods of use thereof.
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