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Solid phase organic synthesis device with pressure-regulated manifold

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C08F-025/100
  • B01J-019/00
출원번호 US-0900120 (1997-07-25)
발명자 / 주소
  • Hamper Bruce C.
출원인 / 주소
  • Monsanto Company
대리인 / 주소
    Bonner
인용정보 피인용 횟수 : 59  인용 특허 : 13

초록

A solid phase organic synthesis device comprising a manifold and an optional heating block mounted to an upper surface of the manifold. The manifold includes an internal cavity and a first array of holes coupled to the internal cavity. The heating block includes a second array of holes vertically al

대표청구항

[ What is claimed is:] [1.] A solid phase organic synthesis arrangement, comprising:a manifold having a first array of holes opening into the interior of said manifold;a plurality of flow-through reaction vessels having openings at the top and bottom and retained in respective ones of said holes of

이 특허에 인용된 특허 (13)

  1. Brennan Thomas M. (San Francisco CA), Apparatus and method for polymer synthesis using arrays.
  2. Zuckermann Ronald N. (Berkeley CA) Banville Steven (San Francisco CA), Automated apparatus for use in peptide synthesis.
  3. Bennett Richard N. (Arbutus MD) Buckley Lawrence W. (Baltimore MD), Dual lane filling machine.
  4. Greene James Albert (455 Tiffany Richardson TX 75080), In-case bottle filling apparatus.
  5. Greene James A. (10655 Blackwalnut Dallas TX 75243), In-case container filling machine.
  6. Sagawa Takayoshi (Yokohama JPX) Tani Shichisei (Yokohama JPX), Liquid charging method.
  7. Redmond ; Jr. Melvin W. (Claremont CA) Good Thomas J. (Sierra Madre CA), Liquid-solid extraction apparatus and method of using same.
  8. Zuckermann Ronald N. (Berkeley CA) Heubner Verena D. (Benicia CA) Santi Daniel V. (San Francisco CA) Siani Michael A. (Oakland CA), Method and apparatus for biopolymer synthesis.
  9. McGraw Royal A. (Athens GA) Grosse William M. (Athens GA), Method for automated synthesis of oligonucleotides.
  10. Thoma Hans A. (Munich DEX), Multichannel system for the handling of immobilized biologically active substances.
  11. Gruenstein Eric I. (Cincinnati OH) Turner Richard T. (Cincinnati OH), Multiple efflux apparatuses for transferring fluid.
  12. Ellman Jonathan A. (Berkeley CA), Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support.
  13. Wachob George D. (State College PA) Rightnour Robert W. (Mingoville PA), Vacuum manifold for extraction processing.

이 특허를 인용한 특허 (59)

  1. Seul, Michael; Xia, Xiongwu; Chau, Chiu; Determan, Scott, Analysis, secure access to, and transmission of array images.
  2. Xia, Xiongwu; Seul, Michael; Chau, Chiu; Determan, Scott, Analysis, secure access to, and transmission of array images.
  3. Madden, Alfred P; Hoshizaki, Jon; Halsey, Jason H.; Moring, Stephen E.; Oldham, Mark F.; Bodner, Kevin S., Apparatus and method for avoiding cross-contamination due to pendent drops of fluid hanging from discharge conduits.
  4. Paul Mansky ; Richard Tiede ; Steve Havadtoy, Apparatus and method for testing compositions in contact with a porous medium.
  5. Banerjee, Sukanta; Seul, Michael; Li, Alice X., Arrays of magnetic particles.
  6. Xia, Xiongwu; Seul, Michael, Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification.
  7. Inoue, Takaaki, Automated chemical synthesizer.
  8. Kelly S. Smith ; Mike Mayer ; Claudia deSouza ; Fred L. Singleton, Biofilm growth device.
  9. Antonenko Valery V. ; Kulikov Nicolay V., Chemical synthesizers.
  10. Moore, Thomas; Kiehntopf, Michael, Cold box with a rack loaded with tube-shaped vessels for automated filling by an automated pipetting device.
  11. Banerjee, Sukanta; Yang, Jiacheng; Seul, Michael, Creation of functionalized microparticle libraries by oligonucleotide ligation or elongation.
  12. Erden, Lynn Van; Turner, Howard; Lowe, David M., High pressure parallel reactor.
  13. Erden,Lynn Van; Turner,Howard; Lowe,David M., High pressure parallel reactor.
  14. Van Erden, Lynn; Turner, Howard; Lowe, David M., High pressure parallel reactor.
  15. Van Erden,Lynn; Chandler, Jr.,William H., High pressure parallel reactor with individually isolatable vessels.
  16. Van Erden,Lynn; Chandler, Jr.,William H., High pressure parallel reactor with individually isolatable vessels.
  17. Erden,Lynn Van; Chandler, Jr.,William H., High pressure parallel reactor with individually sealable vessels.
  18. Rosso, Victor W.; Young, Glen; Nolfo, Joseph; Vit z, Imre M.; Venit, John J., High throughput X-ray diffraction filter sample holder.
  19. Yang, Jiacheng, Kits for multiplexed nucleic acid analysis by capture of single-stranded DNA produced from double-stranded target fragments.
  20. Reed, Mark T.; Hoshizaki, Jon, Manually-operable multi-well microfiltration apparatus and method.
  21. Weinfield,Todd A.; Lim,Gary; Sandell,Donald R.; Bodner,Kevin S.; Borodkin,Mark; Oldham,Mark; Hoshizaki,Jon, Manually-operable multi-well microfiltration apparatus and method.
  22. Lockwood,Mark D.; Peake,Steven C., Method and apparatus for determining liquid absorption of aggregate.
  23. Lockwood,Mark D.; Peake,Steven C., Method and apparatus for determining liquid absorption of aggregate.
  24. Kelsey, Donald Ross; Kiibler, Kathleen Suzanne, Method and apparatus for screening of polycondensation catalysts.
  25. Mansky, Paul, Method for evaluating a test fluid.
  26. Paul Mansky, Method for evaluating a test fluid.
  27. Seul, Michael, Method of making a microbead array with attached biomolecules.
  28. Seul, Michael, Method of making a microbead array with attached biomolecules.
  29. Diamond, Gary M.; Hall, Keith A.; McWaid, Thomas Harding; Murphy, Vince; Myslovaty, Michael; Shoemaker, James A. W.; Sidhu, Robbie Singh; Turner, Howard; Dias, Eric; Spitkovsky, Mikhail, Methods for chemical reactions in a parallel batch reactor.
  30. Freitag, J. Christopher; Hajduk, Damian; Nielsen, Ralph B.; Safir, Adam; Tiede, Richard, Methods for parallel semi-continuous or continuous reactions.
  31. Antonenko Valery V. ; Kulikov Nicolay V., Methods for parallel synthesis of organic compounds.
  32. Wang, Xinwen; Banerjee, Sukanta, Microparticles with enhanced covalent binding capacity and their uses.
  33. Mirzabekov Andrei Darievich,RUX ; Lysov Yuri Petrovich,RUX ; Dubley Svetlana A.,RUX, Miniaturized reaction vessel system, method for performing site-specific biochemical reactions and affinity fractionation for use in DNA sequencing.
  34. Roger Q. Roberts ; Michael R. Woelk, Multi-well filtration apparatus.
  35. Kevin S. Bodner ; Alfred P. Madden ; Joseph Jackson ; Jason H. Halsey ; Mark T. Reed ; Ward Frye ; Mark F. Oldham ; Stephen E. Moring ; Jon Hoshizaki, Multi-well microfiltration apparatus.
  36. Bodner, Kevin S.; Madden, Alfred P.; Halsey, Jason H.; Oldham, Mark F.; Moring, Stephen E.; Hoshizaki, Jon, Multi-well microfiltration apparatus and method for avoiding cross-contamination.
  37. McLuen,Gary R.; Hanney,Richard J.; Hugens,Daniel W., Multi-well rotary synthesizer.
  38. McLuen,Gary R.; Hanney,Richard J.; Hugens,Daniel W., Multi-well rotary synthesizer.
  39. Banerjee, Sukanta; Seul, Michael, Multianalyte molecular analysis using application-specific random particle arrays.
  40. Anderson,Brent J.; Gillespie,Ralph D.; Bricker,Maureen L., Multiautoclave with set of vessels for combinatorial synthesis of zeolites and other materials.
  41. Hoffman, Hans-Jürgen; Hillebrand, Timo; Bendzko, Peter, Multiwell filtration plate.
  42. Cracauer, Raymond F.; Skrzypczynski, Zbigniev; Reimer, Ned D.; Ganske, Rocky, Nucleic acid synthesizers.
  43. Cracauer,Raymond F.; Ziarno,Witold A., Nucleic acid synthesizers.
  44. Seul, Michael; Chau, Chiu Wo; Tan, Enqing, Number coding for identification of subtypes of coded types of solid phase carriers.
  45. Seul, Michael; Banerjee, Sukanta; Yang, Jiacheng; Vener, Tatiana, Optimization of gene expression analysis using immobilized capture probes.
  46. Seul, Michael; Banerjee, Sukanta; Yang, Jiacheng; Vener, Tatiana, Optimization of gene expression analysis using immobilized capture probes.
  47. Diamond, Gary M.; Hall, Keith A.; McWaid, Thomas Harding; Murphy, Vince; Myslovaty, Michael; Shoemaker, James A. W.; Sidhu, Robbie Singh; Turner, Howard; Dias, Eric; Spitkovsky, Mikhail, Parallel batch reactor with pressure monitoring.
  48. Zhou,Xiao Ping; Bergh,Sam; Dube,Christopher E.; Van Erden,Lynn, Parallel reactor with knife-edge seal.
  49. Freitag,J. Christopher; Hajduk,Damian; Nielsen,Ralph B.; Safir,Adam; Tiede,Richard, Parallel semi-continuous or continuous reactor system.
  50. Donald R. Sandell ; Kevin S. Bodner ; Mark Borodkin ; Mark Oldham ; Jon Hoshizaki, Purification apparatus and method.
  51. Weinfield, Todd A.; Lim, Gary; Sandell, Donald R.; Bodner, Kevin S.; Borodkin, Mark; Oldham, Mark; Hoshizaki, Jon, Sample tray heater module.
  52. Weinfield,Todd A.; Lim,Gary; Sandell,Donald R.; Bodner,Kevin S.; Borodkin,Mark; Oldham,Mark; Hoshizaki,Jon, Sample tray heater module.
  53. Campbell David A. ; Antonenko Valery V. ; Selick Harold E. ; Gavin Robert M. ; Ida Satoru ; Muir Arthur H., System and method for solid-phase parallel synthesis of a combinatorial collection of compounds.
  54. Antonenko Valery V. ; Kulikov Nicolay V. ; Jacobs Jeffrey W., System for parallel synthesis of organic compounds.
  55. Antonenko Valery V. ; Kulikov Nicolay, Systems and methods for the synthesis of organic compounds.
  56. Cunliffe, John Graham, Test apparatus.
  57. Grover, Joel W., Thermal cycling device.
  58. Seul, Michael; Banerjee, Sukanta; Podual, Kairali; Hong, Ye, Un-supported polymeric film with embedded microbeads.
  59. Alles,Harold Gene, Valve manifold for HVAC zone control.
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