초록 ▼

According to the invention, hydrating agents in ultrafine form may be incorporated in an organic coating solution with a uniform distribution that does not change due to settling. In preferred embodiments, the coating solution comprises salt dissolved in an appropriate organic solvent blend. In anot

According to the invention, hydrating agents in ultrafine form may be incorporated in an organic coating solution with a uniform distribution that does not change due to settling. In preferred embodiments, the coating solution comprises salt dissolved in an appropriate organic solvent blend. In another embodiment, the hydrating agent may be in the form of ultrafine particles dispersed in the polymer solution. The dispersion may be obtained by adding a stream of the aqueous hydrating agent solution to the organic polymer solution in a controlled fashion, or salt particles may be formed in the polymer solution by acid-base neutralization in solution. The coating solutions are storage stable. When applied to a medical device, the coating solution produces a homogenous coating with desirable performance characteristics. The coatings of the invention adhere to the substrate but not to moist tissue with which they are placed in contact. The coatings of the invention provide indwelling devices with long-lasting lubricity after the device is inserted in a body.

대표청구항 ▼

[ We claim:] [1.] A method of coating a substrate comprising:providing a hydrophilic polymer dissolved in a solvent, the hydrophilic polymer solvent adapted to dissolve or to disperse a hydrating agent, and comprising less than about 25% water by volume;adding to the hydrophilic polymer solvent a hy

[ We claim:] [1.] A method of coating a substrate comprising:providing a hydrophilic polymer dissolved in a solvent, the hydrophilic polymer solvent adapted to dissolve or to disperse a hydrating agent, and comprising less than about 25% water by volume;adding to the hydrophilic polymer solvent a hydrating agent in an amount greater than about 10% as a percentage of the total weight of the hydrophilic polymer and hydrating agent, the hydrating agent being dissolved or an ultrafine dispersion having particle size less than about 10 microns;coating the substrate with the hydrophilic polymer and hydrating agent in the hydrophilic polymer solvent; andforming a hydrophilic coating that adheres to the substrate, becomes lubricious when wet, retains physiologically acceptable lubriciousness after contacting physiological media during a predetermined period of indwelling, is sufficiently smooth to avoid causing physiologically unacceptable trauma to tissue during insertion or removal, and has physiologically acceptable low cellular adhesiveness after contacting the tissue during a predetermined period of indwelling.