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| 국가/구분 | United States(US) Patent 등록 |
|---|---|
| 국제특허분류(IPC7판) |
|
| 출원번호 | US-0556744 (1995-11-02) |
| 우선권정보 | IE-0000864 (1994-11-04) |
| 발명자 / 주소 |
|
| 출원인 / 주소 |
|
| 대리인 / 주소 |
|
| 인용정보 | 피인용 횟수 : 998 인용 특허 : 0 |
A liquid delivery device comprising a housing having a lower surface for application to the skin of a subject and having a reservoir and a gas generation chamber therein separated by a displaceable membrane. Gas generated by an electrolytic cell under the control of a microprocessor causes the gas g
A liquid delivery device comprising a housing having a lower surface for application to the skin of a subject and having a reservoir and a gas generation chamber therein separated by a displaceable membrane. Gas generated by an electrolytic cell under the control of a microprocessor causes the gas generation chamber to expand and the reservoir to contract, thereby discharging a liquid drug, such as insulin, from the reservoir via a hollow delivery needle extending from the lower surface. The delivery needle and a sensor needle both extend from the lower surface a sufficient distance so as to penetrate through the epidermis and into the dermis when the housing is pressed against the skin. The sensor needle has an enzymatic coating for the detection of an analyte, such as glucose in the subject's plasma. The delivery needle is made of platinum-iridium, and a current passes between the needles and a potentiostat circuit according to the amount of glucose detected. A reference electrode (silver/silver chloride) which rests against the subject's skin increases the accuracy of the glucose measurement. The current through the potentiostat circuit is measured by a voltmeter and a signal from the voltmeter is amplified and communicated to the microprocessor which determines the correct rate of delivery of the drug on the basis of the level of analyte detected in the subject's plasma.
[ What is claimed is:] [1.] A device for monitoring the concentration of an analyte in a subject, comprising:a housing having a lower surface for application to the skin of the subject;means for holding the housing in position with the lower surface against the subject's skin;an electrical detection
[ What is claimed is:] [1.] A device for monitoring the concentration of an analyte in a subject, comprising:a housing having a lower surface for application to the skin of the subject;means for holding the housing in position with the lower surface against the subject's skin;an electrical detection circuit comprising a power source connected across two electrodes mounted on said lower surface and switching means, the circuit being completed upon application of the lower surface to the skin of the subject, one of said electrodes being a sensor needle for penetrating through the epidermis and into the dermis when the lower surface is applied to the skin and having an enzyme associated therewith, said enzyme being specific to the analyte to be detected, and the switching means allowing the current through the circuit to flow intermittently to the sensor needle; anda communication circuit comprising means for measuring the current through said electrical detection circuit, means for calculating the concentration of the analyte from the measured current and communicating means for communicating the calculated concentration to the subject.
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