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Methods for generating polynucleotides having desired characteristics by iterative selection and recombination 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12Q-001/68
  • C12N-015/00
출원번호 US-0564955 (1995-11-30)
발명자 / 주소
  • Stemmer Willem P. C.
  • Crameri Andreas
출원인 / 주소
  • Affymax Technologies N.V., ANX
대리인 / 주소
    Townsend & Townsend & Crew
인용정보 피인용 횟수 : 483  인용 특허 : 9

초록 ▼

A method for DNA reassembly after random fragmentation, and its application to mutagenesis of nucleic acid sequences by in vitro or in vivo recombination is described. In particular, a method for the production of nucleic acid fragments or polynucleotides encoding mutant proteins is described. The p

대표청구항 ▼

[ What is claimed is:] [1.] A method for evolving a green fluorescent protein (GFP) protein and a polynucleotide encoding same, comprising(1) providing a population of DNA segments encoding GFP at least one of which is in cell-free form;(2) shuffling the population of DNA segments encoding GFP where

이 특허에 인용된 특허 (9)

  1. Goodman Thomas C. (Mountain View CA) Becker Martin (Palo Alto CA) Ullman Edwin F. (Atherton CA) Rose Samuel (Mountain View CA), Amplification method for polynucleotide assays.
    상세보기
  2. Hartley James L. (Frederick MD), Amplification of nucleic acid sequences using oligonucleotides of random sequence as primers.
    상세보기
  3. Gray Gregory L. (South San Francisco CA), Hybrid prokaryotic polypeptides produced by in vivo homologous recombination.
    상세보기
  4. Grandi Guido (Segrate ITX) De Ferra Francesca (Lodi ITX) Galli Giuliano (Monterotondo ITX) Cosmina Paola (Milan ITX), Method for genetically manipulating peptide synthetases.
    상세보기
  5. Goeddel David V. (Hillsborough CA) Rice Glenn C. (Palo Alto CA) Leung David W. H. (Foster City CA), Method for making variant secreted proteins with altered properties.
    상세보기
  6. Khosla Chaitan (Stanford CA) Caren Robert (Stanford CA), Method of generating multiple protein variants and populations of protein variants prepared thereby.
    상세보기
  7. Prasher Douglas (East Falmouth MA), Modified apoaequorin having increased bioluminescent activity.
    상세보기
  8. Prasher Douglas (Falmouth MA), Modified apoaequorin having increased bioluminescent activity.
    상세보기
  9. Wu Kun C. (Omaha NE), PCR-based strategy of constructing chimeric DNA molecules.
    상세보기

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  124. delCardayre Stephen ; Tobin Matthew ; Stemmer William P. C. ; Ness Jon E. ; Minshull Jeremy ; Patten Phillip ; Subramanian Venkiteswatan ; Castle Linda ; Bass Steve, Evolution of whole cells and organisms by recursive sequence recombination.
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  125. delCardayre, Stephen; Tobin, Matthew B.; Stemmer, Willem P. C.; Ness, Jon E.; Minshull, Jeremy S.; Patten, Phillip A.; Subramanian, Venkiteswatan Mani; Castle, Linda A.; Krebber, Claus M.; Bass, Steven H.; Zhang, Ying Xin; Cox, Anthony R.; Huisman, Gjalt W.; Yuan, Ling; Affholter, Joseph A., Evolution of whole cells and organisms by recursive sequence recombination.
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  126. delCardayre, Stephen; Tobin, Matthew; Stemmer, William P. C.; Ness, Jon E.; Minshull, Jeremy; Patten, Phillip, Evolution of whole cells and organisms by recursive sequence recombination.
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  127. delCardayre, Stephen; Tobin, Matthew; Stemmer, William P. C.; Ness, Jon E.; Minshull, Jeremy; Patten, Phillip; Subramanian, Venkiteswaran; Castle, Linda; Krebber, Claus M.; Bass, Steve, Evolution of whole cells and organisms by recursive sequence recombination.
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  128. delCardayre,Stephen; Tobin,Matthew; Stemmer,Willem P. C.; Ness,Jon E.; Minshull,Jeremy; Patten,Phillip; Subramanian,Venkiteswatan; Castle,Linda A.; Krebber,Claus M.; Bass,Steve; Zhang,Ying Xin; Cox,T, Evolution of whole cells and organisms by recursive sequence recombination.
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  129. Willem P. C. Stemmer, Evolving conjugative transfer of DNA by recursive recombination.
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  130. Liu, David R.; Gartner, Zev J.; Calderone, Christopher T., Evolving new molecular function.
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  131. Liu, David R.; Gartner, Zev J.; Doyon, Jeffrey B.; Calderone, Christopher T.; Kanan, Matthew W.; Li, Xiaoyu; Snyder, Thomas M.; Rosenbaum, Daniel M., Evolving new molecular function.
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  132. Liu, David R.; Gartner, Zev J.; Kanan, Matthew W., Evolving new molecular function.
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  133. Liu, David R.; Gartner, Zev J.; Kanan, Matthew W., Evolving new molecular function.
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  134. Liu,David R.; Gartner,Zev J.; Calderone,Christopher T., Evolving new molecular function.
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  135. Liu,David R.; Gartner,Zev J.; Kanan,Matthew W., Evolving new molecular function.
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  136. Liu,David R.; Gartner,Zev J.; Kanan,Matthew W., Evolving new molecular function.
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  137. Liu,David R.; Gartner,Zev; Kanan,Matthew W., Evolving new molecular function.
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  138. Willem P. C. Stemmer, Evolving susceptibility of cellular receptors to viral infection by recursive recombination.
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  139. Jay M. Short ; Gerhard J. Frey ; Tsotne D. Djavakhishvili, Exonucease-mediated gene assembly in directed evolution.
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  140. Short, Jay M., Exonuclease-mediated gene assembly in directed evolution.
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  141. Jay M. Short ; Tsotne David Djavakhishvili ; Gerhard Johann Frey, Exonuclease-mediated nucleic acid reassembly in directed evolution.
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  142. Short, Jay M., Exonuclease-mediated nucleic acid reassembly in directed evolution.
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  143. Short, Jay M.; Djavakhishvili, Tsotne David; Frey, Gerhard Johann, Exonuclease-mediated nucleic acid reassembly in directed evolution.
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  144. Shock, Jennifer L.; Clark, Louis, Expression constructs comprising fungal promoters.
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  145. DeFrees, Shawn; Zopf, David; Bayer, Robert; Bowe, Caryn; Hakes, David; Chen, Xi, Factor VII: remodeling and glycoconjugation of Factor VII.
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  146. DeFrees, Shawn; Zopf, David A.; Bayer, Robert J.; Bowe, Caryn; Hakes, David James; Chen, Xi, Factor VIII: remodeling and glycoconjugation of factor VIII.
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  147. Johnson, Leslie S.; Rainey, Godfrey Jonah Anderson; Gorlatov, Sergey; Lerner, Laura, Fc region-containing polypeptides that exhibit improved effector function due to alterations of the extent of fucosylation, and methods for their use.
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  148. Punnonen, Juha; Bass, Steven H.; Whalen, Robert Gerald; Howard, Russell; Stemmer, Willem P. C., Flavivirus and alphavirus recombinant antigen libraries.
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  149. Liu, David R.; Sakurai, Kaori, Free reactant use in nucleic acid-templated synthesis.
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  150. Fong, Ryan; Zhang, Xiyun; Noriega, Chris; Agard, Nicholas; Gohel, Anupam; Smith, Derek, Fungal beta-xylosidase variants.
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  151. Fong, Ryan; Zhang, Xiyun; Noriega, Chris; Agard, Nicholas; Gohel, Anupam; Smith, Derek, Fungal beta-xylosidase variants.
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  152. Szabo, Lorand; Molnar, Zsolt; Nemeth, Attila Laszlo, Fungal proteases.
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  153. Monod,Michel; Stocklin,Reto; Grouzmann,Eric, Fungal proteins and nucleic acids encoding same.
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  154. Monod,Michel; Stocklin,Reto; Grouzmann,Eric, Fungal proteins and nucleic acids encoding same.
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  155. Agard, Nicholas John; Elgart, David; Yang, Jie; Banerjee, Goutami; Benoit, Jeanne Bonomo; Baidyaroy, Dipnath, Fungal xylanases and xylosidases.
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  156. Hsieh, Pei-Chung; Sun, Luo; Evans, Jr., Thomas C.; Davis, Theodore B.; Gardner, Andrew, Fusion polymerase and method for using the same.
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  157. Yang, Jie; Zhang, Xiyun; Yoon, Jungjoo; Rao, Kripa; Grate, John H.; Elgart, David; Baidyaroy, Dipnath, GH61 glycoside hydrolase protein variants and cofactors that enhance GH61 activity.
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  158. Yang, Jie; Zhang, Xiyun; Yoon, Jungjoo; Rao, Kripa; Grate, John H.; Elgart, David; Baidyaroy, Dipnath, GH61 glycoside hydrolase protein variants and cofactors that enhance GH61 activity.
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  159. Li Zhu ; Shaobing Benjamin Hua, Generation of highly diverse library of expression vectors via homologous recombination in yeast.
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  160. Chiang,Wen; Strasburg,Gale; Linz,John, Genetic test for PSE-susceptible turkeys.
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  161. Kurn, Nurith; Wang, Shenglong, Global amplification using a randomly primed composite primer.
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  162. Kurn, Nurith; Wang, Shenglong, Global amplification using a randomly primed composite primer.
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  163. Arnold,Frances H.; Sun,Lian Hong; Petrounia,Ioanna P., Glucose 6-oxidases.
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  164. DeFrees, Shawn; Bayer, Robert J.; Zopf, David A., Glycopegylated erythropoietin.
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  165. DeFrees, Shawn; Zopf, David A.; Bowe, Caryn Lang, Glycopegylated erythropoietin.
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  166. DeFrees, Shawn; Bayer, Robert J.; Zopf, David A.; Kang, Jichao; Willett, Walter Scott, Glycopegylated erythropoietin formulations.
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  167. DeFrees, Shawn; Bayer, Robert J.; Bowe, Caryn L.; Panneerselvam, Krishnasamy, Glycopegylated factor IX.
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  168. DeFrees, Shawn; Bayer, Robert J.; Bowe, Caryn; Paneerselvam, Krishnasamy, Glycopegylated factor IX.
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  169. DeFrees, Shawn; Bayer, Robert J.; Bowe, Caryn; Panneer-Selvam, Krishnasamy, Glycopegylated factor IX.
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  170. DeFrees, Shawn; Clausen, Henrik; Zopf, David A.; Bowe, Caryn; Taudte, Susann; Felo, Michael; Willett, Walter S., Glycopegylated granulocyte colony stimulating factor.
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  171. DeFrees, Shawn; Zopf, David A.; Clausen, Henrik; Xing, Ruye, Glycopegylated interferon α.
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  172. DeFrees, Shawn; Zopf, David A.; Bayer, Robert J.; Hakes, David James; Bowe, Caryn L.; Chen, Xi, Glycopegylation methods and proteins/peptides produced by the methods.
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  173. DeFrees, Shawn; Zopf, David A.; Bayer, Robert J.; Hakes, David James; Bowe, Caryn; Chen, Xi, Glycopegylation methods and proteins/peptides produced by the methods.
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  174. DeFrees, Shawn, Glycosylation of peptides via O-linked glycosylation sequences.
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  175. DeFrees, Shawn; Zopf, David A.; Bayer, Robert J.; Bowe, Caryn; Hakes, David James; Chen, Xi, Granulocyte colony stimulating factor: remodeling and glycoconjugation G-CSF.
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  176. Kannan, Gunasekaran; Florio, Monica; Liu, Zhi; Yan, Wei, Heterodimeric immunoglobulins.
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  177. Kannan, Gunasekaran; Florio, Monica; Liu, Zhi; Yan, Wei, Heterodimeric immunoglobulins.
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  178. Thomas, Michael George; Felnagle, Elizabeth Anne; Rondon, Michelle Renee; Berti, Andrew David, Heterologous production of capreomycin and generation of new capreomycin derivatives through metabolic engineering.
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  179. Osslund, Timothy D., High concentration antibody formulations.
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  180. Osslund, Timothy David, High concentration antibody formulations.
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  181. Chew, Lawrence C.; Lee, Stacey L., High copy number self-replicating plasmids in pseudomonas.
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  182. Zhu, Li; Wei, Shuanghong; Hua, Shaobing B., High throughput generation and affinity maturation of humanized antibody.
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  183. Li Zhu ; Shaobing Benjamin Hua, High throughput generation and screening of fully human antibody repertoire in yeast.
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  184. Raillard,Sun Ai; Chen,Yong Hong; Krebber,Claus; Minshull,Jeremy; Stemmer,Willem P. C., High throughput mass spectrometry.
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  185. Li Zhu ; Shaobing Benjamin Hua, Highly diverse library of yeast expression vectors.
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  186. Lassner, Michael; delCardayre, Steven, Homologous recombination in plants.
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  187. Li, Yi, Human G-protein chemokine receptor HSATU68.
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  188. Hua, Shaobing; Pauling, Michelle Haynes; Zhu, Li, Human monoclonal antibody against coreceptors for human immunodeficiency virus.
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  189. Doris Apt ; Paul Khavari ; William P. C Stemmer, Human papilloma virus vectors.
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  190. Reyes, Christopher L.; Chu, Peter; Smith, Kristen M.; Campbell, Lioudmila A.; Shojaei, Farbod; Norton, John Thomas, Humanized antibodies that bind LGR5.
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  191. Dayton, Christopher L. G.; Hitchman, Tim; Kline, Katie; Lyon, Jonathan; Wall, Mark A.; Barton, Nelson R., Hydrolases, nucleic acids encoding them and methods for biocatalytic synthesis of structured lipids.
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  192. Dayton, Christopher L. G.; Hitchman, Tim; Kline, Katie; Lyon, Jonathan; Wall, Mark A.; Barton, Nelson R., Hydrolases, nucleic acids encoding them and methods for biocatalytic synthesis of structured lipids.
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  193. Dayton, Christopher L. G.; Barton, Nelson; Bueno, Analia; Cuenca, Joslin G.; Hitchman, Tim; Kline, Katie A.; Lyon, Jonathan; Miller, Mark L.; Wall, Mark A., Hydrolases, nucleic acids encoding them and methods for making and using them.
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  194. Dayton, Christopher L. G.; Barton, Nelson; Bueno, Analia; Cuenca, Joslin G.; Hitchman, Tim; Kline, Katie A.; Lyon, Jonathan; Miller, Mark L.; Wall, Mark A., Hydrolases, nucleic acids encoding them and methods for making and using them.
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  195. Dayton, Christopher L. G.; Hitchman, Tim; Kline, Katie; Lyon, Jonathan; Wall, Mark A.; Barton, Nelson R., Hydrolases, nucleic acids encoding them and methods for making and using them.
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  196. Dayton, Christopher L. G.; Hitchman, Tim; Kline, Katie; Lyon, Jonathan; Wall, Mark A.; Barton, Nelson R., Hydrolases, nucleic acids encoding them and methods for making and using them for biocatalytic synthesis of a structured lipid.
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  197. Dayton, Christopher L. G.; Hitchman, Tim; Kline, Katie; Lyon, Jonathan; Wall, Mark A.; Barton, Nelson R., Hydrolases, nucleic acids encoding them and methods to produce triglycerides.
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  198. Dayton, Christopher L. G.; Hitchman, Tim; Kline, Katie; Lyon, Jonathan; Wall, Mark A.; Barton, Nelson R., Hydrolases, nucleic acids encoding them and methods to produce triglycerides.
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  199. Campana, Raffaela; Valenta, Rudolf; Vrtala, Susanne; Swoboda, Ines; Focke-Tejkl, Margarete; Gieras, Anna; Spitzauer, Susanne; Valent, Peter; Blatt, Katharina; Linhart, Birgit; Kraft, Dietrich, Hypallergenic mosaic antigens and methods of making same.
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  200. Duffy, Hao-Peng Xu, Identificiaton of differentially methylated and mutated nucleic acids.
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  201. Selifonov,Sergey A.; Stemmer,Willem P. C.; Gustafsson,Claes; Tobin,Matthew; del Cardayre,Stephen; Patten,Phillip A.; Minshull,Jeremy, Identifying oligonucleotides for in vitro recombination.
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  202. DiCosimo, Robert; Ben-Bassat, Arie, Immobilized microbial nitrilase for production of glycolic acid.
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  203. Winkler, David G.; Shi, Jiye; Latham, John, Immunogenic peptides derived from sclerostin.
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  204. Benkovic,Stephen J.; Ostermeier,Marc; Lutz,Stefan; Nixon,Andrew E., Incrementally truncated nucleic acids and methods of making same.
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  205. Bass,Steven H.; Davis,S. Christopher; Patten,Phillip A.; Tobin,Matthew; Minshull,Jeremy; Welch,Mark; Gustafsson,Claes; Carr,Brian; Jenne,Stephane; Raillard,Sun Ai; Crameri,Andreas; Stemmer,Willem P. C.; Emig,Robin; Longchamp,Pascal; Goldman,Stanley; Giver,Lorraine J.; Affholter,Joseph A., Integrated system for diversity generation and screening.
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  206. Bass, Steven H.; Davis, Simon Christopher; Patten, Phillip A.; Tobin, Matthew; Minshull, Jeremy S.; Welch, Mark; Gustafsson, Claus; Carr, Brian; Jenne, Stephan J.; Raillard, Sun Ai; Crameri, Andreas; Stemmer, Willem P. C.; Emig, Robin; Longchamp, Pascal; Goldman, Stanley; Giver, Lorraine J.; Affholter, Joseph A., Integrated systems and methods for diversity generation and screening.
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  207. Kurn, Nurith; Wang, Shenglong, Isothermal nucleic acid amplification methods and compositions.
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  208. Arnold, Frances H.; Otey, Christopher R., Libraries of optimized cytochrome P450 enzymes and the optimized P450 enzymes.
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  209. Giver, Lorraine J.; Minshull, Jeremy; Vogel, Kurt, Lipase genes.
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  210. Giver,Lorraine J.; Minshull,Jeremy; Vogel,Kurt, Lipase genes.
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  211. Hinderer, Walter; Scheckermann, Christian, Liquid formulation of G-CSF conjugate.
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  212. Paul, Sudhir, Lupus antibodies for passive immunotherapy of HIV/AIDS.
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  213. Thomas,Michael G.; Chan,Yolanda A.; Ozanick,Sarah G., Metabolic engineering of viomycin biosynthesis.
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  214. Gustafsson, Claes; Govindarajan, Sridhar; Minshull, Jeremy S.; Ness, Jon E.; Emig, Robin A., Method and system using systematically varied data libraries.
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  215. Emig, Robin A.; Fox, Richard John; Gustafsson, Claes; Govindarajan, Sridhar; Minshull, Jeremy S.; Cavet, Guy, Method and/or apparatus for determining codons.
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  216. Kumagai Monto H. ; della-Cioppa Guy R., Method for conferring herbicide, pest, or disease resistance in plant hosts.
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  217. Arnold, Frances; Shao, Zhixin; Volkov, Alexander, Method for creating polynucleotide and polypeptide sequences.
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  218. Arnold, Frances; Shao, Zhixin; Volkov, Alexander, Method for creating polynucleotide and polypeptide sequences.
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  219. Arnold,Frances; Shao,Zhixin; Volkov,Alexander, Method for creating polynucleotide and polypeptide sequences.
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  220. Stemmer Willem P. C., Method for directing evolution of a virus.
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  221. Wayne P. Fitzmaurice ; John A. Lindbo ; Hal S. Padgett ; Gregory P. Pogue, Method for expressing a library of nucleic acid sequence variants and selecting desired traits.
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  222. Carl Arne Krister Borrebaeck SE; Ulf Hans Eskil Soderlind SE; Rebecka Ingrid Camilla Ottosson SE, Method for in vitro molecular evolution of protein function.
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  223. Carlsson, Roland; Hager, Ann Christin Malmborg; Furebring, Christina; Borrebaeck, Carl, Method for in vitro molecular evolution of protein function.
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  224. Carlsson, Roland; Hager, Ann-Christin Malmborg; Furebring, Christina; Borrebaeck, Carl, Method for in vitro molecular evolution of protein function.
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  225. Carlsson, Roland; Hager, Ann-Christin Malmborg; Furebring, Christina; Borrebaeck, Carl, Method for in vitro molecular evolution of protein function.
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  226. Carlsson,Roland; Hager,Ann Christin Malmborg; Furebring,Christina; Borrebaeck,Carl, Method for in vitro molecular evolution of protein function.
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  227. Soderlind,Ulf Hans Eskil; Borrebaeck,Carl Arne Krister, Method for in vitro molecular evolution of protein function.
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  228. Soderlind,Ulf Hans Eskil; Borrebaeck,Carl Arne Krister, Method for in vitro molecular evolution of protein function.
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  229. Borrebaeck,Carl Arne Krister; Malmborg Hager,Ann Christin; Furebring,Christina; Soderlind,Ulf Hans Eskil; Ottosson,Rebecka Ingrid Camilla, Method for in vitro molecular evolution of protein function involving the use of exonuclease enzyme and two populations of parent polynucleotide sequence.
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  230. Borrebaeck Carl Arne Krister,SEX ; Soderlind Ulf Hans Eskil,SEX ; Ottosson Rebecka Ingrid Camilla,SEX, Method for in vitro molecular evolution of protein function using exonuclease and amplification.
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  231. Furebring,Christina; Carlsson,Roland; Borrebaeck,Carl Arne Krister; Malmborg Hager,Ann Christin, Method for in vitro molecular evolution of protein function using varied exonuclease digestion in two polynucleotide populations.
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  232. Padhi, Ian Desmond; Jang, Graham Richard, Method for inhibiting bone resorption.
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  233. Padhi, Ian Desmond; Jang, Graham Richard, Method for inhibiting bone resorption.
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  234. Padhi, Ian Desmond; Jang, Graham Richard, Method for inhibiting bone resorption.
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  235. Padhi, Ian Desmond; Jang, Graham Richard, Method for inhibiting bone resorption.
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  236. Selifonov, Sergey A.; Stemmer, Willem P. C.; Gustafsson, Claes; Tobin, Matthew; del Cardayre, Stephen; Patten, Phillip A.; Minshull, Jeremy; Giver, Lorraine J., Method for making polynucleotides having desired characteristics.
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  237. Delcourt,Marc; Blesa,Stephane, Method for massive directed mutagenesis.
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  238. Miyawaki, Atsushi; Sawano, Asako, Method for mutagenesis.
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  239. DiCosimo, Robert; Cahill, William R.; DiPietro, David George; Hann, Eugenia Costa; Reynolds, Richard Alan, Method for producing peroxycarboxylic acid.
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  240. Claus M. Krebber, Method for producing polynucleotides with desired properties.
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  241. Rozzell, Jr., J. David, Method for reductive amination of a ketone using a mutated enzyme.
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  242. Rozzell, Jr.,J. David, Method for reductive amination of a ketone using a mutated enzyme.
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  243. Jay M. Short, Method for screening for enzyme activity.
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  244. Short Jay M., Method for screening for enzyme activity.
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  245. Rak, Bodo; Reski, Ralf; Zimmermann, Susanne; Guitton, Marie-Christine; Duwenig, Elke; Freund, Annette, Method for the mutagenesis of nucleotide sequences in plants algae or fungi.
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  246. Schröder, Hartwig; Kröger, Burkhard; Zelder, Oskar; Klopprogge, Corinna; Häfner, Stefan, Method for the production of sulpher-containing fine chemicals by fermentation.
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  247. Milano, Joseph; Tang, Xiao-Song, Method for the recombination of genetic elements.
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  248. Short Jay M., Method of DNA reassembly by interrupting synthesis.
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  249. Jay M. Short, Method of DNA shuffling.
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  250. Jay M. Short, Method of DNA shuffling with polynucleotides produced by blocking or interrupting a synthesis or amplification process.
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  251. Monto H. Kumagai ; Guy R. della-Cioppa ; Robert L. Erwin ; David R. McGee, Method of compiling a functional gene profile in a plant by transfecting a nucleic acid sequence of a donor plant into a different host plant in an anti-sense orientation.
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  252. Fox, Richard, Method of generating an optimized, diverse population of variants.
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  253. Fox, Richard, Method of generating an optimized, diverse population of variants.
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  254. Fox, Richard, Method of generating an optimized, diverse population of variants.
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  255. Ke, Hua Zhu; Liu, Min; Giannobile, William V., Method of treating alvelor bone loss through the use of anti-sclerostin antibodies.
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  256. Ke, Hua Zhu; Liu, Min; Giannobile, William V., Method of treating alveolar bone loss through the use of anti-sclerostin antibodies.
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  257. Bentires-Alj, Mohamed; Aceto, Nicola; Stadler, Michael, Method of treatment of breast cancers over-expressing the SHP2 signature genes.
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  258. Jeremy Minshull ; Willem P. C. Stemmer, Methods and compositions for cellular and metabolic engineering.
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  259. Minshull Jeremy ; Stemmer Willem P. C., Methods and compositions for cellular and metabolic engineering.
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  260. Minshull, Jeremy; Stemmer, Willem P. C., Methods and compositions for cellular and metabolic engineering.
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  261. Minshull, Jeremy; Stemmer, Willem P. C., Methods and compositions for cellular and metabolic engineering.
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  262. Minshull,Jeremy; Stemmer,Willem P. C., Methods and compositions for cellular and metabolic engineering.
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  263. Menzel,Rolf, Methods and compositions for directed gene assembly.
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  264. Kurn, Nurith, Methods and compositions for generation of multiple copies of nucleic acid sequences and methods of detection thereof.
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  265. Kurn, Nurith, Methods and compositions for generation of multiple copies of nucleic acid sequences and methods of detection thereof.
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  266. Patten Phillip A. ; Stemmer Willem P. C., Methods and compositions for polypeptide engineering.
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  267. Patten Phillip A. ; Stemmer Willem P.C., Methods and compositions for polypeptide engineering.
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  268. Patten, Phillip A.; Stemmer, Willem P. C., Methods and compositions for polypeptide engineering.
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  269. Patten, Phillip A.; Stemmer, Willem P. C., Methods and compositions for polypeptide engineering.
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  270. Patten, Phillip A.; Stemmer, Willem P. C., Methods and compositions for polypeptide engineering.
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  271. Patten, Phillip A.; Stemmer, Willem P. C., Methods and compositions for polypeptide engineering.
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  272. Patten, Phillip A.; Stemmer, Willem P. C., Methods and compositions for polypeptide engineering.
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  273. Patten, Phillip A.; Stemmer, Willem P. C., Methods and compositions for polypeptide engineering.
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  274. Phillip A. Patten ; Willem P. C. Stemmer, Methods and compositions for polypeptide engineering.
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  275. Phillip A. Patten ; Willem P. C. Stemmer, Methods and compositions for polypeptide engineering.
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  276. Phillip A. Patten ; Willem P. C. Stemmer, Methods and compositions for polypeptide engineering.
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  277. Phillip A. Patten ; Willem P. C. Stemmer, Methods and compositions for polypeptides engineering.
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  278. Kink, John A.; Strong, Laura E.; Shahan, Mark N., Methods and compositions for the treatment of cancer.
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  279. Kink, John A; Strong, Laura E.; Shahan, Mark N., Methods and compositions for the treatment of cancer.
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  280. Kurn, Nurith, Methods and compositions for transcription-based nucleic acid amplification.
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  281. Fasan, Rudi; Arnold, Frances H., Methods and systems for selective fluorination of organic molecules.
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  282. Fasan, Rudi; Arnold, Frances H., Methods and systems for selective fluorination of organic molecules.
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  283. Cubicciotti Roger S., Methods for detecting and identifying single molecules.
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  284. Kurn,Nurith; Wang,Martin Junhong, Methods for generating double stranded DNA comprising a 3' single stranded portion and uses of these complexes for recombination.
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  285. Wagner, Richard W.; Wright, Martin C.; Kreider, Brent, Methods for generating highly diverse libraries.
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  286. Stemmer Willem P. C., Methods for generating polynucleotides having desired characteristics by iterative selection and recombination.
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  291. Stemmer Willem P. C., Methods for generating polynucleotides having desired characteristics by iterative selection and recombination.
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  292. Stemmer Willem P. C. ; Crameri Andreas, Methods for generating polynucleotides having desired characteristics by iterative selection and recombination.
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  293. Stemmer Willem P.C., Methods for generating polynucleotides having desired characteristics by iterative selection and recombination.
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  294. Stemmer, Willem P. C., Methods for generating polynucleotides having desired characteristics by iterative selection and recombination.
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  295. Stemmer, Willem P. C., Methods for generating polynucleotides having desired characteristics by iterative selection and recombination.
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  296. Stemmer, Willem P. C.; Crameri, Andreas, Methods for generating polynucleotides having desired characteristics by iterative selection and recombination.
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  298. Stemmer, Willem P. C.; Crameri, Andreas, Methods for generating polynucleotides having desired characteristics by iterative selection and recombination.
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  300. Stemmer,Willem P. C.; Crameri,Andreas, Methods for generating polynucleotides having desired characteristics by iterative selection and recombination.
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  301. Willem P. C. Stemmer, Methods for generating polynucleotides having desired characteristics by iterative selection and recombination.
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  302. Willem P. C. Stemmer, Methods for generating polynucleotides having desired characteristics by iterative selection and recombination.
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  303. Willem P. C. Stemmer ; Andreas Crameri, Methods for generating polynucleotides having desired characteristics by iterative selection and recombination.
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  304. Willem P. C. Stemmer ; Andreas M. Cramieri, Methods for generating polynucleotides having desired characteristics by iterative selection and recombination.
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  305. Selifonov, Sergey A.; Stemmer, Willem P. C.; Gustafsson, Claes; Tobin, Matthew; del Cardayre, Stephen; Patten, Phillip A.; Minshull, Jeremy; Giver, Lorraine J., Methods for identifying sets of oligonucleotides for use in an in vitro recombination procedure.
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  306. Selifonov, Sergey A.; Stemmer, Willem P. C.; Gustafsson, Claes; Tobin, Matthew; del Cardayre, Stephen; Patten, Phillip A.; Minshull, Jeremy, Methods for making character strings, polynucleotides and polypeptides having desired characteristics.
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  307. Selifonov,Sergey A.; Stemmer,Willem P. C.; Gustafsson,Claes; Tobin,Matthew; del Cardayre,Stephen; Patten,Phillip A.; Minshull,Jeremy; Giver,Lorraine J., Methods for making character strings, polynucleotides and polypeptides having desired characteristics.
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  308. Selifonov,Sergey A.; Stemmer,Willem P. C.; Gustafsson,Claes; Tobin,Matthew; del Cardayre,Stephen; Patten,Phillip A.; Minshull,Jeremy; Giver,Lorraine J., Methods for making character strings, polynucleotides and polypeptides having desired characteristics.
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  309. De Block, Marc; Meulewaeter, Frank; Bulone, Vincent; Guerriero, Gea, Methods for manufacturing plant cell walls comprising chitin.
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  310. Brunkow,Mary E; Galas,David J; Kovacevich,Brian; Mulligan,John T; Paeper,Bryan W; Van Ness,Jeffrey; Winkler,David G, Methods for modulating bone mineralization.
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  311. Short, Jay M., Methods for obtaining a desired bioactivity or biomolecule using DNA libraries from an environmental source.
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  312. Stemmer, Willem P. C., Methods for producing recombined antibodies.
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  313. Willem P.C. Stemmer, Methods for recombining nucleic acids.
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  314. DeFrees, Shawn; Kinealy, Kyle, Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography.
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  315. Kurn, Nurith, Methods of RNA amplification in the presence of DNA.
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  316. Willem P. C. Stemmer, Methods of evolving a polynucleotides by mutagenesis and recombination.
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  317. Reyes, Christopher L.; Chu, Peter; Tan, Xiangyang; Graff, Christilyn; Yang, Weixing, Methods of inhibiting growth of a colon cancer tumor in a subject by administering monoclonal antibodies to G protein-coupled receptor 49 (GPR49).
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  318. Reyes, Christopher L.; Chu, Peter; Tan, Xiangyang; Graff, Christilyn; Yang, Weixing, Methods of inhibiting solid tumor growth by administering GPR49 antibodies.
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  319. Selifonov, Sergey A.; Stemmer, Willem P. C., Methods of populating data structures for use in evolutionary simulations.
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  320. Selifonov, Sergey A.; Stemmer, Willem P. C., Methods of populating data structures for use in evolutionary simulations.
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  321. Selifonov, Sergey A.; Stemmer, Willem P. C., Methods of populating data structures for use in evolutionary simulations.
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  322. Selifonov, Sergey A.; Stemmer, Willem P. C., Methods of populating data structures for use in evolutionary simulations.
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  323. Selifonov,Sergey A.; Stemmer,Willem P. C., Methods of populating data structures for use in evolutionary simulations.
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  324. Reyes, Christopher L.; Chu, Peter; Tan, Xiangyang; Yang, Weixing; Graff, Christilyn, Methods of treating cancer by administering anti-GPR49 antibodies.
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  325. Zopf, David A.; Lubenau, Heinz, Methods of treatment using glycopegylated G-CSF.
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  326. Kurn, Nurith, Methods, kits and compositions for single primer linear isothermal amplification of nucleic acid sequences.
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  327. Anderson, Norman G.; Anderson, N. Leigh, Microarrays and their manufacture.
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  328. Anderson, Norman G.; Anderson, N. Leigh, Microarrays and their manufacture.
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  329. Anderson, Norman G.; Anderson, N. Leigh; Braatz, James A., Microarrays and their manufacture.
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  330. Anderson,N. Leigh; Anderson,Norman G.; Braatz,James A., Microarrays and their manufacture by slicing.
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  331. Serber, Zach; Dean, Erik Jedediah; Manchester, Shawn; Gora, Katherine; Flashman, Michael; Shellman, Erin; Kimball, Aaron; Szyjka, Shawn; Frewen, Barbara; Treynor, Thomas; Bruno, Kenneth S., Microbial strain improvement by a HTP genomic engineering platform.
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  332. Serber, Zach; Dean, Erik Jedediah; Manchester, Shawn; Gora, Katherine; Flashman, Michael; Shellman, Erin; Kimball, Aaron; Szyjka, Shawn; Frewen, Barbara; Treynor, Thomas; Bruno, Kenneth S., Microbial strain improvement by a HTP genomic engineering platform.
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  333. Stemmer, Willem P. C.; Patten, Phillip; Soong, Nay Wei, Modification of virus tropism and host range by viral genome shuffling.
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  334. Willem P. C. Stemmer ; Venkiteswaran Subramanian, Modified ADP-glucose pyrophosphorylase for improvement and optimization of plant phenotypes.
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  335. Kink, John A.; Strong, Laura E.; Trubetskoy, Vladimir; Shahan, Mark N., Modified ribonucleases.
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  336. Nu��ez,Gabriel; Inohara,Naohiro; Ogura,Yasunori, Modulators of Nod2 signaling.
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  337. Dicosimo, Robert; Ben-Bassat, Arie; Cahill, William R.; Dipietro, David George; Hann, Eugenia Costa; Payne, Mark S.; Reynolds, Richard Alan; Zolandz, Raymond Richard, Multi-component peracid generation system.
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  338. Marliere, Philippe; Pochet, Sylvie; Bouzon, Madeleine, Mutants of deoxycytidine kinase having extended enzymatic activity.
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  339. Bryan Julien ; Leonard Katz ; Chaitan Khosla, Myxococcus host cells for the production of epothilones.
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  340. Strong, Laura E.; Leland, Peter A.; Burke, Thomas, Non-natural ribonuclease conjugates as cytotoxic agents.
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  341. Strong, Laura E.; Leland, Peter A.; Burke, Thomas, Non-natural ribonuclease conjugates as cytotoxic agents.
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  342. Strong, Laura E.; Leland, Peter A.; Burke, Thomas, Non-natural ribonuclease conjugates as cytotoxic agents.
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  343. Short, Jay M., Non-stochastic generation of genetic vaccines and enzymes.
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  344. Kurn, Nurith; Wang, Shenglong, Nucleic acid amplification procedure using RNA and DNA composite primers.
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  345. Jarrell, Kevin A.; Coljee, Vincent W.; Donahue, William; Mikheeva, Svetlana, Nucleic acid cloning.
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  346. Jarrell,Kevin A.; Coljee,Vincent W.; Donahue,William; Mikheeva,Svetlana, Nucleic acid cloning.
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  347. Weglarz, Thaddeus; Gachotte, Daniel; Blakeslee, Beth; Larrinua, Ignacio; McCrery, David A.; Pell, Randy J.; Oriedo, J. Vincent B.; Miller, Barbara A.; Reddy, Avutu S.; Shukla, Vipula; Crosley, Rodney, Nucleic acid compositions conferring altered metabolic characteristics.
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  348. Stemmer, Willem P. C., Nucleic acid libraries.
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  349. Dunlap, Jay C.; Loros, Jennifer; Mehra, Arun; Gooch, Van D., Nucleic acid sequences encoding luciferase for expression in filamentous fungi.
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  350. Liu, David R.; Bittker, Joshua A., Nucleic acid shuffling.
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  351. Mary E. Brunkow ; David J. Galas ; Brian Kovacevich ; John T. Mulligan ; Bryan W. Paeper ; Jeffrey Van Ness ; David G. Winkler, Nucleic acids encoding a novel family of TGF-.beta. binding proteins from humans.
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  352. Hao-Peng Xu Duffy, Nucleic acids that encode testes specific protease and detect DNA hypomethylated in cancer cells.
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  353. Felo, Michael; DeFrees, Shawn, Nucleotide sugar purification using membranes.
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  354. DeFrees, Shawn; Zopf, David A.; Wang, Zhi-Guang; Clausen, Henrik, O-linked glycosylation of peptides.
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  355. DeFrees,Shawn; Zopf,David A.; Wang,Zhi Guang; Clausen,Henrik, O-linked glycosylation of peptides.
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  356. Dayton, Christopher L. G.; Galhardo, Flavio Da Silva; Barton, Nelson; Hitchman, Tim; Lyon, Jonathan; O'Donoghue, Eileen; Wall, Mark A., Oil degumming methods.
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  357. Dayton, Christopher L. G.; Galhardo, Flavio Da Silva; Barton, Nelson; Hitchman, Tim; Lyon, Jonathan; O'Donoghue, Eileen; Wall, Mark A., Oil degumming methods.
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  358. Andreas Crameri CH; Willem P. C. Stemmer ; Jeremy Minshull ; Steven H. Bass ; Mark Welch ; Jon E. Ness ; Claes Gustafsson ; Phillip A. Patten, Oligonucleotide mediated nucleic acid recombination.
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  359. Andreas Crameri CH; Willem P. C. Stemmer ; Jeremy Minshull ; Steven H. Bass ; Mark Welch ; Jon E. Ness ; Claes Gustafsson ; Phillip A. Patten, Oligonucleotide mediated nucleic acid recombination.
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  360. Andreas Crameri CH; Willem P. C. Stemmer ; Jeremy Minshull ; Steven H. Bass ; Mark Welch ; Jon E. Ness ; Claes Gustafsson ; Phillip A. Patten, Oligonucleotide mediated nucleic acid recombination.
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  361. Andreas Crameri CH; Willem P. C. Stemmer ; Jeremy Minshull ; Steven H. Bass ; Mark Welch ; Jon E. Ness ; Claes Gustafsson ; Phillip A. Patten, Oligonucleotide mediated nucleic acid recombination.
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  362. Crameri Andreas,CHX ; Stemmer Willem P.C. ; Minshull Jeremy ; Bass Steven H. ; Welch Mark ; Ness Jon E. ; Gustafsson Claes ; Patten Phillip A., Oligonucleotide mediated nucleic acid recombination.
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  363. Crameri, Andreas; Stemmer, Willem P. C.; Minshull, Jeremy; Bass, Steven H.; Welch, Mark; Ness, John E.; Gustafsson, Claes; Patten, Phillip A., Oligonucleotide mediated nucleic acid recombination.
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  364. Crameri, Andreas; Stemmer, Willem P. C.; Minshull, Jeremy; Bass, Steven H.; Welch, Mark; Ness, Jon E.; Gustafsson, Claes; Patten, Phillip A., Oligonucleotide mediated nucleic acid recombination.
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  365. Crameri, Andreas; Stemmer, Willem P. C.; Minshull, Jeremy; Bass, Steven H.; Welch, Mark; Ness, Jon E.; Gustafsson, Claes; Patten, Phillip A., Oligonucloetide mediated nucleic acid recombination.
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  366. DeFrees, Shawn; Zopf, David A.; Taudte, Susann; Willett, Walter Scott; Bayer, Robert J.; Kalo, Matthew, One pot desialylation and glycopegylation of therapeutic peptides.
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  367. Punnonen,Juha; Stemmer,Willem P. C.; Whalen,Robert Gerald; Howard,Russell J., Optimization of immunomodulatory properties of genetic vaccines.
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  368. Willem P. C. Stemmer ; Linda A. Castle ; Takashi Yamamoto, Optimization of pest resistance genes using DNA shuffling.
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  369. Kevin A. Jarrell ; Vincent W. Coljee ; William Donahue ; Svetlana Mikheeva, Ordered gene assembly.
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  370. Owyang,Chung, Orphanin FQ receptor.
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  371. Owyang, Chung, Orphanin FQ receptor nucleic acids.
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  372. Arnold, Frances H.; Joo, Hyun; Lin, Zhanglin, Oxygenase enzymes and screening method.
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  373. Osborne, Robert; Mitchell, Vesna; Htwe, Khin Yu Naing; Zhang, Xiyun; Milczek, Erika M.; Moore, Jeffrey C., P450-BM3 variants with improved activity.
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  374. Osborne, Robert; Mitchell, Vesna; Htwe, Khin Yu Naing; Zhang, Xiyun; Milczek, Erika M.; Moore, Jeffrey C., P450-BM3 variants with improved activity.
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  375. Osborne, Robert; Mitchell, Vesna; Htwe, Khin Yu Naing; Zhang, Xiyun; Milczek, Erika M.; Moore, Jeffrey C., P450-BM3 variants with improved activity.
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  376. Osborne, Robert; Mitchell, Vesna; Htwe, Khin Yu Naing; Zhang, Xiyun; Milczek, Erika M.; Moore, Jeffrey C., P450-BM3 variants with improved activity.
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  377. Klausen, Niels Kristian; Bjorn, Soren; Behrens, Carsten; Garibay, Patrick William, Pegylated factor VII glycoforms.
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  378. Banerjee, Goutami; Yang, Jie; Zhang, Xiyun; Milczek, Erika M.; Mayo, Melissa Ann; Jenne, Stephan, Penicillin-G acylases.
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  379. Alvizo, Oscar; Miller, Mathew G.; Mijts, Benjamin N.; Meshulam-Simon, Galit; McDaniel, Robert, Pentose fermentation by a recombinant microorganism.
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  380. Subbian, Ezhilkani; Grate, John H.; Cho, Catherine M.; Mijts, Benjamin N.; Benoit, Jeanne Bonomo, Pentose fermentation by a recombinant microorganism.
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  381. Subbian, Ezhilkani; Grate, John H.; Cho, Catherine M.; Mijts, Benjamin; Benoit, Jeanne Bonomo, Pentose fermentation by a recombinant microorganism.
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  382. Zhang, Xiyun; Fong, Ryan C.; Subbian, Ezhilkani, Pentose fermentation by a recombinant microorganism.
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  383. Zhang, Xiyun; Fong, Ryan C.; Subbian, Ezhilkani, Pentose fermentation by a recombinant microorganism.
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  384. DiCosimo, Robert; Gavagan, John Edward; Payne, Mark Scott, Perhydrolase for enzymatic peracid production.
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  385. DiCosimo, Robert; Payne, Mark S.; Yin, Tyler, Perhydrolases for enzymatic peracid generation.
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  386. Dicosimo, Robert; Payne, Mark S.; Yin, Tyler, Perhydrolases for enzymatic peracid generation.
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  387. Cirino, Patrick C.; Arnold, Frances H., Peroxide-driven cytochrome P450 oxygenase variants.
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  388. Cirino,Patrick C.; Arnold,Frances H., Peroxide-driven cytochrome P450 oxygenase variants.
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  389. Solbak, Jr., Arne I., Phytase.
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  390. Tan, Xuqiu; Solbak, Jr., Arne I., Phytase.
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  391. Osteryoung, Katherine W.; Vitha, Stanislav; Koksharova, Olga A.; Gao, Hongbo, Plastid division and related genes and proteins, and methods of use.
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  392. Feder,John N.; Nelson,Thomas C.; Chen,Jian; Meegalla,Rupalie; Ramaker,Michael; Cheng,Dong, Polynucleotide encoding a novel acyl coenzyme A, monoacylglycerol acyltransferase-3 (MGAT3), and uses thereof.
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  393. Paszty, Christopher J., Polynucleotide encoding a sclerostin-binding antibody.
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  394. Stutzman-Engwall, Kim J.; Chen, Yan; Gustafsson, Claes; Krebber, Anke; Minshull, Jeremy; Raillard, Sun Ai, Polynucleotides and methods of directing the ratio of B2:B1 avermectins in host cells.
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  395. Punnonen, Juha; Bass, Steven H.; Whalen, Robert Gerald; Howard, Russell; Stemmer, Willem P. C., Polynucleotides encoding flavivirus and alphavirus multivalent antigenic polypeptides.
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  396. Mary E. Brunkow ; David J. Galas ; Brian Kovacevich ; John T. Mulligan ; Bryan W. Paeper ; Jeffrey Van Ness ; David G. Winkler, Polypeptides associated with alterations in bone density.
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  397. DiCosimo, Robert; Panova, Anna; Arthur, Samuel D.; Chenault, Henry Keith, Process for enzymatically converting glycolonitrile to glycolic acid.
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  398. DiCosimo, Robert; Panova, Anna; Arthur, Samuel D.; Chenault, Henry Keith, Process for enzymatically converting glycolonitrile to glycolic acid.
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  399. DiCosimo, Robert; Panova, Anna; Chenault, Henry Keith; Arthur, Samuel David, Process for enzymatically converting glycolonitrile to glycolic acid.
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  400. Dicosimo, Robert; Panova, Anna; Arthur, Samuel D.; Chenault, Henry Keith, Process for enzymatically converting glycolonitrile to glycolic acid.
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  401. Dicosimo, Robert; Panova, Anna; Arthur, Samuel D.; Chenault, Henry Keith, Process for enzymatically converting glycolonitrile to glycolic acid.
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  402. Dicosimo, Robert; Panova, Anna; Arthur, Samuel D.; Keith, Henry, Process for enzymatically converting glycolonitrile to glycolic acid.
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  403. Brieden, Walter; Naughton, Andrew; Robins, Karen; Shaw, Nicholas; Tinschert, Andreas; Zimmermann, Thomas, Process for the preparation of (S)-or (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid.
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  404. Brieden,Walter; Naughton,Andrew; Robins,Karen; Shaw,Nicholas; Tinschert,Andreas; Zimmermann,Thomas, Process for the preparation of (S)-or (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid.
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  405. DeFrees, Shawn; Bowe, Caryn, Process for the production of purified cytidinemonophosphate-sialic acid-polyalkylene oxide (CMP-SA-PEG) as modified nucleotide sugars via anion exchange chromatography.
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  406. Payne,Mark S.; DiCosimo,Robert; O'Keefe,Daniel P., Production of 3-hydroxycarboxylic acid using nitrilase mutants.
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  407. Short Jay M., Production of enzymes having desired activities by mutagenesis.
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  408. Chamberlain, Jeffrey S.; Hartigan-O'Connor, Dennis J., Production of viral vectors.
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  409. Chamberlain, Jeffrey S.; Hartigan-O'Connor, Dennis J., Production of viral vectors.
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  410. Chamberlain, Jeffrey S.; Hartigan-O'Connor, Dennis J., Production of viral vectors.
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  411. Chamberlain, Jeffrey S.; Hartigan-O'Connor, Dennis J., Production of viral vectors.
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  412. Paul, Sudhir; Nishiyama, Yasuhiro, Proteolytic and covalent antibodies.
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  413. Jendrisak, Jerome J.; Vaidyanathan, Ramesh; Meis, Ronald, RNA polyphosphatase compositions, kits, and uses thereof.
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  414. Lietz Eric, Random mutagenesis and amplification of nucleic acid.
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  415. Vasquez, Maximiliano; Feldhaus, Michael; Gerngross, Tillman U.; Wittrup, K. Dane, Rationally designed, synthetic antibody libraries and uses therefor.
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  417. Vasquez, Maximiliano; Feldhaus, Michael; Gerngross, Tillman U.; Wittrup, K. Dane, Rationally designed, synthetic antibody libraries and uses therefor.
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  418. Vasquez, Maximiliano; Feldhaus, Michael; Gerngross, Tillman U.; Wittrup, K. Dane, Rationally designed, synthetic antibody libraries and uses therefor.
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  419. Liu, David R.; Kanan, Matthew William; Rozenman, Mary M., Reaction discovery system.
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  420. Julien, Bryan; Katz, Leonard; Khosla, Chaitan; Tang, Li; Ziermann, Rainer, Recombinant methods and materials for producing epothilone and epothilone derivatives.
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  421. Julien, Bryan; Katz, Leonard; Khosla, Chaitan; Tang, Li; Ziermann, Rainer, Recombinant methods and materials for producing epothilone and epothilone derivatives.
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  422. Julien, Bryan; Katz, Leonard; Khosla, Chaitan; Tang, Li; Ziermann, Rainer, Recombinant methods and materials for producing epothilone and epothilone derivatives.
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  423. Julien,Bryan; Katz,Leonard; Khosla,Chaitan; Tang,Li; Ziermann,Rainer, Recombinant methods and materials for producing epothilone and epothilone derivatives.
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  424. Julien,Bryan; Katz,Leonard; Khosla,Chaitan; Tang,Li; Ziermann,Rainer, Recombinant methods and materials for producing epothilone and epothilone derivatives.
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  425. Julien Bryan ; Katz Leonard ; Khosla Chaitan ; Tang Li, Recombinant methods and materials for producing epothilones C and D.
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  426. Phillip A. Patten ; Volker Heinrichs ; Willem P. C. Stemmer, Recombination of insertion modified nucleic acids.
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  427. Phillip A. Patten ; Volker Heinrichs ; Willem P. C. Stemmer, Recombination of insertion modified nucleic acids.
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  428. Phillip A. Patten ; Volker Heinrichs ; Willem P. C. Stemmer, Recombination of insertion modified nucleic acids.
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  429. Phillip A. Patten ; Volker Heinrichs ; Willem P. C. Stemmer, Recombination of insertion modified nucleic acids.
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