초록 ▼

A process for impregnating a medical device made from a water absorbable polymer material, e.g., a hydrogel, with a medical compound having low solubility in aqueous solutions, e.g., an antiseptic or radiopaque compound, is disclosed. The device is first infiltrated with an aqueous solution containi

A process for impregnating a medical device made from a water absorbable polymer material, e.g., a hydrogel, with a medical compound having low solubility in aqueous solutions, e.g., an antiseptic or radiopaque compound, is disclosed. The device is first infiltrated with an aqueous solution containing a first water soluble, ionizable compound, and subsequently infiltrated with an aqueous solution containing a second water soluble, ionizable compound. The ionizable compounds are selected such that they react after mutual contact to form the medical compound in-situ within the device.

대표청구항 ▼

[ What is claimed is:] [1.] A process for impregnating a medical device comprising a water absorbable polymer material with a medical compound having water solubility less than about 0.5 g/liter comprising:a) contacting at least a portion of said device with a first aqueous solution containing a fir

[ What is claimed is:] [1.] A process for impregnating a medical device comprising a water absorbable polymer material with a medical compound having water solubility less than about 0.5 g/liter comprising:a) contacting at least a portion of said device with a first aqueous solution containing a first water soluble ionizable compound dissolved therein such that the contacted portion of said device is infiltrated by said first aqueous solution;b) contacting said portion of said device with a second aqueous solution containing a second water soluble ionizable compound dissolved therein such that the contacted portion of said device is also infiltrated by said second aqueous solution;said water soluble compounds characterized by the fact that the ions thereof react after contact to form said medical compound having water solubility less than about 0.5 g/liter within said device,said water absorbable polymer material comprising ionically or covalently crosslinked hydrogel; andsaid medical compound being selected from the group consisting of radiopaque compounds present in said device at a level of from about 5 to about 15 wt % and antiseptic agents present in said device at a level of from about 0.01 to about 5 wt %.