초록 ▼

A device, drug package and methodology for using such to generate an aerosol by moving a flowable formulation through a low resistance filter and then through a nozzle comprised of a porous membrane are disclosed. The package is comprised of a collapsible wall portion that forms a container for hold

A device, drug package and methodology for using such to generate an aerosol by moving a flowable formulation through a low resistance filter and then through a nozzle comprised of a porous membrane are disclosed. The package is comprised of a collapsible wall portion that forms a container for holding a liquid formulation which container has an opening covered by a cover portion comprising a nozzle. The membrane pores of the nozzle have a size in the range of 0.25 to 6 microns, preferably 0.5 to 6 microns. A low resistance filter, which is positioned between the flowable formulation and the nozzle, includes openings that are the same size as or smaller than the pores of the nozzle's porous membrane but includes the openings in an amount and density such that flowable formulation flows through the filter with less resistance than when the formulation moves through the porous membrane. Thus, the filter does not significantly increase the amount of pressure needed to aerosolize the formulation, prevents clogging of the porous membrane of the nozzle by any undesirable particles that may be in the formulation, prevents delivery of any such undesirable particles to the patient, and thereby improves the homogeneity of the aerosol formulation delivered to the patient, as well as the consistency and reproducibility of the aerosolized dose created.

대표청구항 ▼

[ What is claimed is:] [1.] A disposable package for use in aerosolized delivery of a flowable formulation comprising a drug or diagnostic agent, comprising:a container having at least one wall which is collapsible by the application of a force and having at least one opening, the container having t

[ What is claimed is:] [1.] A disposable package for use in aerosolized delivery of a flowable formulation comprising a drug or diagnostic agent, comprising:a container having at least one wall which is collapsible by the application of a force and having at least one opening, the container having therein a flowable formulation;a nozzle covering the opening wherein the nozzle is comprised of a porous membrane having pores of a diameter in the range of from about 0.25 micron to about 50 microns; anda low resistance filter positioned between the nozzle and the flowable formulation, wherein the filter has openings, the openings being present at a porosity such that the flow resistance of the filter is substantially the same as or less than the flow resistance of the porous membrane.