[특허]Cationic lipids and the use thereof

Cationic lipids and the use thereof 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-091/27 G01N-033/92 C07K-017/04 C07H-021/04
출원번호	US-0391938 (1995-02-21)
발명자 / 주소	Unger Evan C. Shen Dekang Wu Guanli
출원인 / 주소	ImaRx Pharmaceutical Corp.
대리인 / 주소	Woodcock Washburn Kurtz Mackiewicz & Norris LLP
인용정보	피인용 횟수 : 143 인용 특허 : 187

초록 ▼

Cationic lipid compounds which comprise at least two cationic groups. The cationic lipid compounds are particularly suitable for use as carriers in the intracellular delivery of bioactive agents, including pharmaceuticals and genetic material. Compositions of the present cationic lipid compounds inc

대표청구항 ▼

[ We claim:] [1.] A cationic lipid compound of the formula: [ STR 22 ] wherein: each of x, y and z is independently an integer from 0 to about 100;each X.sub.1 is independently --O--, --S--, --NR.sub.5 --, --C(.dbd.X.sub.2)--, --C(.dbd.X.sub.2)--N(R.sub.5)--, --N(R.sub.5)--C(.dbd.X.sub.2)--, --C(.dbd.X.sub.2)--O--, --O--C(.dbd.X.sub.2)-- or --X.sub.2 --(R.sub.5 X.sub.2)P(.dbd.X.sub.2)--X.sub.2 --;each X.sub.2 is independently O or S;each Y.sub.1 is independently a phosphate residue, N(R.sub.6).sub.a --, S(R.sub.6).sub.a --, P(R.sub.6).sub.a -- or --CO.sub.2 R.sub.6, wherein a is an integer from 1 to 3;each Y.sub.2 is independently --N(R.sub.6).sub.b --, --S(R.sub.6).sub.b -- or --P(R.sub.6).sub.b --, wherein b is an integer from 0 to 2;each Y.sub.3 is independently a phosphate residue, N(R.sub.6).sub.a --, S(R.sub.6).sub.a --, P(R.sub.6).sub.a -- or --CO.sub.2 R.sub.6, wherein a is an integer from 1 to 3;each of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 is independently alkylene of 2 to about 20 carbons;each R.sub.5 is independently hydrogen or alkyl of 1 to about 10 carbons; andeach R.sub.6 is independently --[R.sub.7 --X.sub.3 ].sub.c --R.sub.8 or --R.sub.9 --[X.sub.4 --R.sub.10 ].sub.d --Q, wherein:each of c and d is independently an integer from 0 to about 100;each Q is independently a phosphate residue, --N(R.sub.11).sub.q, --S(R.sub.11).sub.q, --P(R.sub.11).sub.q or --CO.sub.2 R.sub.11, wherein q is an integer from 1 to 3;each of X.sub.3 and X.sub.4 is independently --O--, --S--, --NR.sub.5 --, --C(.dbd.X.sub.2)--, --C(.dbd.X.sub.2)--N(R.sub.5)--, --N(R.sub.5)--C(.dbd.X.sub.2)--, --C(.dbd.X.sub.2)--O--, --O--C(.dbd.X.sub.2)-- or --X.sub.2 --(R.sub.5 X.sub.2)P(.dbd.X.sub.2)--X.sub.2 --;each R.sub.7 is independently alkylene of 2 to about 20 carbons;each R.sub.8 is independently hydrogen or alkyl of 1 to about 60 carbons;each of R.sub.9 and R.sub.10 is independently alkylene of 2 to about 20 carbons; andeach R.sub.11 is independently --[R.sub.7 --X.sub.3 ].sub.c --R.sub.8 or --R.sub.9 --[X.sub.4 --R.sub.10 ].sub.d --W, wherein:each W is independently a phosphate residue, --N(R.sub.12).sub.w, --S(R.sub.12).sub.w, --P(R.sub.12).sub.w or --CO.sub.2 R.sub.12, wherein w is an integer from 1 to 3; andR.sub.12 is --[R.sub.7 --X.sub.3 ].sub.c --R.sub.8 ; with the proviso that the compound of formula (I) comprises at least two quaternary salts.

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Nair Mridula (Penfield NY) Tan Julia S. (Rochester NY), Microgel drug delivery system.
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Eppstein Deborah A. (Menlo Park CA) Felgner Philip L. (Los Altos CA) Gadek Thomas R. (Oakland CA) Jones Gordon H. (Cupertino CA) Roman Richard B. (Fairhope AL), N-(www 상세보기

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관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표IPC

저장형식

Text(ASCII format)
Excel format
PIAS분석(.xls)

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안내

총 건의 자료가 검색되었습니다.

다운받으실 자료의 인덱스를 입력하세요. (1-10,000)

검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다.

데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요)

다운로드 파일은 UTF-8 형태로 저장됩니다.
파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오.

Text(ASCII format)
Excel format

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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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Cationic lipids and the use thereof 원문보기

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내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표IPC 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 공고번호, 공고일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표출원인, 출원인국적, 출원인주소, 발명자, 발명자E, 발명자코드, 발명자주소, 발명자 우편번호, 발명자국적, 대표IPC, IPC코드, 요약, 미국특허분류, 대리인주소, 대리인코드, 대리인(한글), 대리인(영문), 국제공개일자, 국제공개번호, 국제출원일자, 국제출원번호, 우선권, 우선권주장일, 우선권국가, 우선권출원번호, 원출원일자, 원출원번호, 지정국, Citing Patents, Cited Patents
저장형식	Text(ASCII format) Excel format PIAS분석(.xls)
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

Cationic lipids and the use thereof 원문보기

초록 ▼

대표청구항 ▼

연구과제 타임라인

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