초록 ▼

A method of increasing the nitric oxide concentration in the blood of a human, which comprises: (a) contacting from about 0.01 ml to about 400 ml of blood with a nitric oxide concentration-increasing effective amount of ozone gas and ultraviolet radiation; and (b) administering the treated blood to

A method of increasing the nitric oxide concentration in the blood of a human, which comprises: (a) contacting from about 0.01 ml to about 400 ml of blood with a nitric oxide concentration-increasing effective amount of ozone gas and ultraviolet radiation; and (b) administering the treated blood to a human. The method of the invention is useful for treating a variety of conditions benefitted by increased blood levels of nitric oxide.

대표청구항 ▼

[ What is claimed is:] [1.] A method of inducing relaxation of the smooth muscle of blood vessels of a human patient to effect enlargement in the diameter of said blood vessels, which comprises the successive steps of:(a) extracting an aliquot of blood, of volume from about 0.01 ml to about 400 ml,

[ What is claimed is:] [1.] A method of inducing relaxation of the smooth muscle of blood vessels of a human patient to effect enlargement in the diameter of said blood vessels, which comprises the successive steps of:(a) extracting an aliquot of blood, of volume from about 0.01 ml to about 400 ml, from the human patient;(b) in vitro contacting the extracted aliquot of human blood with a nitric oxide concentration-increasing effective amount of ozone gas as an oxygen/ozone gas stream having an ozone concentration of from 0.5 .mu.g/ml to about 100 .mu.g/ml, and ultraviolet radiation, for a period of time from about 0.5-10 minutes and at a temperature, in the range 0.degree.-56.degree. C., which does not cause marked hemolysis in the blood aliquot or does not cause a major loss of platelets from the blood, to produce an aliquot of treated blood; and(c) increasing the nitric oxide concentration in the blood of said patient by administering said treated blood to the same human patient.