Polymer-lipid microencapsulated gases for use as imaging agents
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-049/04
A61K-009/14
출원번호
US-0681710
(1996-07-29)
발명자
/ 주소
Bernstein Howard
Straub Julie Ann
Brush Henry T.
Church Charles C.
출원인 / 주소
Acusphere, Inc.
대리인 / 주소
Arnall Golden & Gregory, LLP
인용정보
피인용 횟수 :
44인용 특허 :
86
초록▼
It has been discovered that the incorporation of gases, especially fluorinated gases such as perfluorocarbons, into microparticles formed from the combination of a natural or synthetic polymer and lipid have significantly enhanced echogenicity as compared with microparticles not including the lipid.
It has been discovered that the incorporation of gases, especially fluorinated gases such as perfluorocarbons, into microparticles formed from the combination of a natural or synthetic polymer and lipid have significantly enhanced echogenicity as compared with microparticles not including the lipid. Compounds other than lipids which are hydrophobic and limit the penetration and/or uptake of water into the microparticles can also be incorporated into the microparticles to enhance echogenicity. In the preferred embodiment, the polymers are synthetic biodegradable polymers. The microparticles are manufactured with a diameter suitable for the targeted tissue to be imaged, for example, with a diameter of between 0.5 and 8 microns for intravascular administration, and a diameter of between 0.5 and 5 mm for oral administration for imaging of the gastrointestinal tract or other lumens. Preferred polymers are polyhydroxy acids such as polylactic acid-co-glycolic acid, most preferably conjugated to polyethylene glycol or other materials inhibiting uptake by the reticuloendothelial system (RES). The most preferred lipids are phospholipids, preferably dipalmitoylphosphatidylcholine (DPPC), distearoylphosphatidylcholine (DSPC), diarachidoylphosphatidylcholine (DAPC), dibehenoylphosphatidylcholine (DBPC), ditricosanoylphosphatidylcholine, dilignoceroylphatidylcholine (DLPC), incorporated at a ratio of between 0.01-30 (w lipid/w polymer), most preferably between 0.1-10 (w lipid/w polymer). Microparticles for imaging using other detectable agents can be similarly manufactured.
대표청구항▼
[ We claim:] [1.] A method for making microparticles for diagnostic imaging, wherein the microparticles are formed of a biocompatible polymer and have incorporated therein gas, the improvement comprising(a) incorporating into the polymer a hydrophobic compound by either dissolving the polymer and hy
[ We claim:] [1.] A method for making microparticles for diagnostic imaging, wherein the microparticles are formed of a biocompatible polymer and have incorporated therein gas, the improvement comprising(a) incorporating into the polymer a hydrophobic compound by either dissolving the polymer and hydrophobic compound in an organic solvent or melting the polymer with the hydrophobic compound, prior to forming the microparticles, and(b) forming the microparticles by either removing the polymer solvent or cooling the polymer,wherein the hydrophobic compound is mixed with the polymer in the microparticle in an amount effective to increase the echogenicity of the microparticle as compared to the echogenicity of the microparticle without the hydrophobic compound andwherein the hydrophobic compound is selected from the group consisting of fatty acids, fatty acid alcohols, fatty acid anhydrides, hydroxy fatty acids, prostaglandins, phospholipids, sphingolipids, steroids and steroid derivatives, fat soluble vitamins, terpenes, tryptophan, tyrosine, isoleucine, leucine, valine, alkyl paraben, and benzoic acid.
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이 특허에 인용된 특허 (86)
Cook Edward J. (South Hamilton MA) Lagace Arthur P. (Newtonville MA), Apparatus for forming emulsions.
Long ; Jr. David M. (San Diego CA), Biocompatible stable fluorocarbon emulsions for contrast enhancement and oxygen transport comprising 40-125% wt./volume.
Long ; Jr. David M. (El Cajon CA), Biocompatible, stable and concentrated fluorocarbon emulsions for contrast enhancement and oxygen transport in internal.
Hilmann Juergen (Berlin DEX) Hoffmann Rolf-Ruediger (Berlin DEX) Muetzel Wolfgang (Berlin DEX) Zimmermann Ingfried (Berlin DEX), Carrier liquid solutions for the production of gas microbubbles, preparation thereof, and use thereof as contrast medium.
Grinstaff Mark W. (Pasadena CA) Soon-Shiong Patrick (Los Angeles CA) Wong Michael (Champaign IL) Sandford Paul A. (Los Angeles CA) Suslick Kenneth S. (Champaign IL) Desai Neil P. (Los Angeles CA), Composition useful for in vivo delivery of biologics and methods employing same.
Cerny David (Chula Vista CA) Mills Gary J. (San Diego CA) Westkaemper Peter J. (San Diego CA), Continuous sonication method for preparing protein encapsulated microbubbles.
Langer Robert S. (Sommerville MA) Domb Abraham J. (Brookline MA) Laurencin Cato T. (Cambridge MA), Controlled drug delivery high molecular weight polyanhydrides.
Yan Feng (Carouge CHX) Schneider Michel (Troinex CHX) Brochot Jean (Feigeres FRX), Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method.
Schneider Michel (Troinex CHX) Yan Feng (Geneva CHX) Grenier ; deceased Pascal (late of Ambilly FRX by Nadine Garcel ; legal heir ) Puginier Jerome (Le Chable-Beaumont FRX) Barrau Marie-Bernadette (G, Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the prepa.
Schneider Michel (Troinex CHX) Yan Feng (Genve CHX) Grenier ; deceased Pascal (late of Ambilly FRX by Nadine Garcel ; legal heir) Puginier Jrme (Le Chble-Beaumont FRX) Barrau Marie-Bernadette (Geneva, Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the prepa.
Desai Neil P. (Los Angeles CA) Soon-Shiong Patrick (Los Angeles CA) Sandford Paul A. (Los Angeles CA) Grinstaff Mark W. (Pasadena CA) Suslick Kenneth S. (Champaign IL), Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell.
Grinstaff Mark W. (Pasadena CA) Desai Neil P. (Los Angeles CA) Suslick Kenneth S. (Champaign IL) Soon-Shiong Patrick (Los Angeles CA) Sandford Paul A. (Los Angeles CA) Merideth Noma R. (Pacific Palis, Method for the preparation of fluorocarbon-containing polymeric shells for medical imaging.
Unger Evan C. (Tucson AZ) Fritz Thomas A. (Tucson AZ) Matsunaga Terry (Tucson AZ) Ramaswami VaradaRajan (Tucson AZ) Yellowhair David (Tucson AZ) Wu Guanli (Tucson AZ), Method of preparing gas and gaseous precursor-filled microspheres.
Levene Harold B. (San Diego CA) Villapando Elaine (San Diego CA) Barnhart James L. (Encinitas CA) Widder Kenneth J. (Del Mar CA), Method of ultrasound imaging of the gastrointestinal tract.
Unger Evan C. (13365 E. Camino La Cebadilla Tucson AZ 85749), Methods for providing localized therapeutic heat to biological tissues and fluids using gas filled liposomes.
Klaveness Jo (Oslo NLX) Rongved Pal (Hellvik NLX) Stubberud Lars (Sodertalje NLX), Microbubble-generating contrast agents for ultrasound and magnetic resonance imaging.
Grinstaff Mark W. (Pasadena CA) Desai Neil P. (Los Angeles CA) Suslick Kenneth S. (Champaign IL) Soon-Shiong Patrick (Los Angeles CA) Sandford Paul A. (Los Angeles CA) Merideth Noma R. (Pacific Palis, Non-fluorinated polymeric shells for medical imaging.
Charpiot Brigitte (Nice FRX) Greiner Jacques (Nice FRX) Le Blanc Maurice (Nice FRX) Manfredi Alexandre (Nice FRX) Riess Jean (Falicon FRX) Zarif Leila (Nice FRX), Polyhydroxylated and highly fluorinated compounds, their preparation and their use as surfactants.
Grinstaff Mark W. (Pasadena CA) Desai Neil P. (Los Angeles CA) Suslick Kenneth S. (Champaign IL) Soon-Shiong Patrick (Los Angeles CA) Sandford Paul A. (Los Angeles CA) Merideth Noma R. (Pacific Palis, Polymeric shells for medical imaging prepared from synthetic polymers, and methods for the use thereof.
Sutton Andrew D. (Ruddington GB2) Johnson Richard A. (West Bridgford GB2) Senior Peter J. (Near Melbourne GB2) Heath David (The Park GB2), Preparation of diagnostic agents.
Schneider Michel (Troinex CHX) Bichon Daniel (Montpellier FRX) Bussat Philippe (Collonges S/Saleve FRX) Puginier Jerome (Le Chable-Beaumont FRX) Hybl-Sutherland Eva (Wiesbaden DEX), Stable microbubbles suspensions injectable into living organisms.
Liversidge Gary G. (West Chester PA) Cundy Kenneth C. (Pottstown PA) Bishop John F. (Rochester NY) Czekai David A. (Honeoye Falls NY), Surface modified drug nanoparticles.
D\Arrigo Joseph S. (23A Brickyard Rd. Farmington CT 06032), Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures.
Unger Evan C. (Tucson AZ) Fritz Thomas A. (Tucson AZ) Matsunaga Terry (Tucson AZ) Ramaswami VaradaRajan (Tucson AZ) Yellowhair David (Tucson AZ) Wu Guanli (Tucson AZ), Therapeutic delivery systems related applications.
Erbel Raimund (Mainz DEX) Zotz Rainer (Mainz DEX) Krone Volker (Flrsheim DEX) Magerstdt Michael (Hofheim am Taunus DEX) Walch Axel (Frankfurt am Main DEX), Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents.
Rasor Ned S. (Cupertino CA) Hilmann Jurgen (Berlin DEX) Lange Lothar (Berlin DEX) Fritzsch Thomas (Berlin DEX) Siegert Joachim (Berlin DEX) Zimmermann Ingfried (Weiler DEX), Ultrasonic contrast medium comprising gas bubbles and solid lipophilic surfactant-containing microparticles and use ther.
Roth Duane J. (La Jolla CA) Keipert Peter E. (San Diego CA) Faithfull Nicholas S. (Normanton by Bottesford OH GB2) Zuck Thomas F. (Cincinnati OH) Riess Jean G. (Nice FRX), Use of synthetic oxygen carriers to facilitate oxygen delivery.
George, E. Victor; Wyeth, N. Convers; Green, Albert M.; Drobot, Adam T., Design, fabrication, testing, and conditioning of micro-components for use in a light-emitting panel.
George,Edward Victor; Wyeth,Newell Convers; Green,Albert Myron, Design, fabrication, testing, and conditioning of micro-components for use in a light-emitting panel.
Heidlas, Jurgen; Zirzow, Karl-Heinz; Wiesmuller, Johann; Graefe, Jurgen, Homogenous water-free formulations containing glycerophospholipids and polar or lipophilic substances, method for the production thereof.
Green, Albert Myron; Drobot, Adam Thomas; George, Edward Victor; Johnson, Roger Laverne; Wyeth, Newell Convers, Light-emitting panel and a method for making.
Green, Albert Myron; Drobot, Adam Thomas; George, Edward Victor; Johnson, Roger Laverne; Wyeth, Newell Convers, Light-emitting panel and a method for making.
Green, Albert Myron; Drobot, Adam Thomas; George, Edward Victor; Johnson, Roger Laverne; Wyeth, Newell Convers, Light-emitting panel and a method for making.
Drobot, Adam T.; Wyeth, N. Convers; George, E. Victor; Green, Albert M., Method and apparatus for addressing micro-components in a plasma display panel.
George, Edward Victor; Johnson, Roger Laverne; Green, Albert Myron; Wyeth, Newell Convers, Method and system for energizing a micro-component in a light-emitting panel.
Green, Albert Myron; Drobot, Adam Thomas; George, Edward Victor; Johnson, Roger Laverne; Wyeth, Newell Convers, Method for making a light-emitting panel.
Johnson, Roger Laverne; Green, Albert Myron; George, Edward Victor; Wyeth, Newell Convers, Method for testing a light-emitting panel and the components therein.
George, Edward Victor; Drobot, Adam Thomas; Johnson, Roger Laverne; Green, Albert Myron; Wyeth, Newell Convers, Micro-component for use in a light-emitting panel.
George, Edward Victor; Johnson, Roger Laverne; Green, Albert Myron; Wyeth, Newell Convers, Socket for use with a micro-component in a light-emitting panel.
George, Edward Victor; Johnson, Roger Laverne; Green, Albert Myron; Wyeth, Newell Convers, Socket for use with a micro-component in a light-emitting panel.
George, Edward Victor; Johnson, Roger Laverne; Green, Albert Myron; Wyeth, Newell Convers, Socket for use with a micro-component in a light-emitting panel.
George,Edward Victor; Johnson,Roger Laverne; Green,Albert Myron; Wyeth,Newell Convers, Socket for use with a micro-component in a light-emitting panel.
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