IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0459470
(1995-06-02)
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발명자
/ 주소 |
- Burrell Robert Edward,CAX
- Morris Larry Roy,CAX
- Apte Prasad Shrikrishna,CAX
- Sant Sudhindra Bharat,CAX
- Gill Kashmir Singh,CAX
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출원인 / 주소 |
- Westaim Technologies, Inc., CAX
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대리인 / 주소 |
Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P.
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인용정보 |
피인용 횟수 :
78 인용 특허 :
82 |
초록
▼
Anti-microbial coatings and method of forming same on medical devices are provided. The coatings are preferably formed by depositing an anti-microbial, biocompatible metal by vapor deposition techniques to produce atomic disorder in the coating such that a sustained release of metal ions sufficient
Anti-microbial coatings and method of forming same on medical devices are provided. The coatings are preferably formed by depositing an anti-microbial, biocompatible metal by vapor deposition techniques to produce atomic disorder in the coating such that a sustained release of metal ions sufficient to produce an anti-microbial effect is achieved. Preferred deposition conditions to achieve atomic disorder include a lower than normal substrate temperature, and one or more of a higher than normal working gas pressure and a lower than normal angle of incidence of coating flux. Anti-microbial powders formed by vapor deposition or altered by mechanical working to produce atomic disorder are also provided. Novel anti-microbial silver materials are defined, characterized by having a positive rest potential, a T.sub.rec /T.sub.m less than 0.33, and a grain size less than 200 nm. Anti-microbial fine grain or nanocrystalline materials are provided, together with methods of preparation, wherein the anti-microbial metal if deposited in a matrix with atoms or molecules of a different material such as other biocompatible metals (ex. Ta), trapped or absorbed oxygen, or compounds of anti-microbial metals or biocompatible metals (ex. AgO or TaO).
대표청구항
▼
[ We claim:] [1.] A fine grain anti-microbial material, comprising:one or more anti-microbial metals selected from the group consisting of Ag, Au, Pt, Pd, Ir, Sn, Cu, Sb, Bi, and Zn, or an alloy or compound thereof, said metals having a grain size less than 200 nm, and being characterized by suffici
[ We claim:] [1.] A fine grain anti-microbial material, comprising:one or more anti-microbial metals selected from the group consisting of Ag, Au, Pt, Pd, Ir, Sn, Cu, Sb, Bi, and Zn, or an alloy or compound thereof, said metals having a grain size less than 200 nm, and being characterized by sufficient atomic disorder such that the material, in contact with an alcohol or a water based electrolyte, provides a sustained release of atoms, ions, molecules or clusters containing at least one of the anti-microbial metals at an enhanced rate relative to its normal ordered crystalline state and at a concentration sufficient to provide a localized anti-microbial effect, wherein the atomic disorder in the material provides irregularities in surface topography and inhomogeneities in structure on a nanometer scale and is caused by high concentrations of at least one of point defects in a crystal lattice, vacancies, line defects comprising dislocations, interstitial atoms, amorphous regions and grain and sub grain boundaries, relative to a normal ordered crystalline state for the anti-microbial metal.
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