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Telomerase activity assays 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12Q-001/68
  • C12P-019/34
  • C07H-021/02
  • C07H-021/04
출원번호 US-0482132 (1995-06-07)
발명자 / 주소
  • Harley Calvin Bruce
  • Kim Nam Woo
  • Weinrich Scott Lawrence
출원인 / 주소
  • Geron Corporation
대리인 / 주소
    Hughes
인용정보 피인용 횟수 : 14  인용 특허 : 21

초록

Telomerase activity in a sample can be measured using a two reaction protocol involving telomerase substrate and primer extension steps. The presence of telomerase activity in a human somatic tissue or cell sample is positively correlated with the presence of cancer and can be used to diagnose the c

대표청구항

[ What is claimed is:] [1.] A kit for detecting telomerase activity, said kit comprising:(a) a telomerase substrate;(b) a primer comprising a sequence complementary to a telomeric repeat sequence; and(c) instructions.

이 특허에 인용된 특허 (21)

  1. Stapleton Marilyn J. (Durham NC), Device for processing biological specimens for analysis of nucleic acids.
  2. Stapleton Marilyn J. (Durham NC), Device for processing biological specimens for analysis of nucleic acids.
  3. Dattagupta Nanibhushan (New Haven CT) Crothers Donald M. (Northford CT), Fast photochemical method of labelling nucleic acids for detection purposes in hybridization assays.
  4. Comeau Anne M. (Newburyport MA), Method and apparatus for electro-elution of biological molecules.
  5. Livak Kenneth J. (San Jose CA) Flood Susan J. A. (Fremont CA) Marmaro Jeffrey (Foster City CA), Method for detecting nucleic acid amplification using self-quenching fluorescence probe.
  6. Bobrow Mark N. (Woburn MA) Litt Gerald J. (Wellesley MA), Method for the detection or quantitation of an analyte using an analyte dependent enzyme activation system.
  7. Shay Jerry (Dallas TX) West Michael David (Belmont CA) Wright Woodring E. (Arlington TX), Methods for cancer diagnosis and prognosis.
  8. Fisher Mary E. (Oakland CA) Watson Robert M. (Berkeley CA), Methods for in-solution quenching of fluorescently labeled oligonucleotide probes.
  9. Cummins Thomas J. (Rochester NY) Ekeze Tobias D. (Rochester NY), Methods of extracting nucleic acids and PCR amplification without using a proteolytic enzyme.
  10. Burdick Brent A. (Rochester NY) Ekeze Tobias D. (Rochester NY), Methods of extracting, amplifying and detecting a nucleic acid from whole blood or PBMC fraction.
  11. Urdea Michael S. (Alamo CA) Warner Brian (Martinez CA) Horn Thomas (Berkeley CA), Nucleic acid multimers and amplified nucleic acid hybridization assays using same.
  12. Kosak Kenneth M. (3194 S. 4400 W. West Valley City UT 84120) Kosak Matthew K. (3194 S. 4400 W. West Valley City UT 84120), Preparation of wax beads containing a reagent for release by heating.
  13. Di Franco Dino F. (Mayfield Village OH), Process for producing electrodeposited electrodes for use in electrochemical cells.
  14. Reischl Udo (Grafenau DEX) Rueger Rudiger (Seeshaupt DEX) Kessler Christoph (Dorfen DEX) Seibl Rudolf (Penzberg DEX), Process for the specific production of ribonucleic acids.
  15. Reischl Udo (Grafenau DEX) Rueger Ruediger (Seeshaupt DEX) Kaletta Cortina (Munich DEX) Kessler Christoph (Dorgen DEX) Kleiber Joerg (Penzberg DEX), Promotor controlled specific amplification of nucleic acid sequences.
  16. Bohn Joseph W. (San Diego CA) Cohen Peter A. (San Diego CA) Zuraw Bruce L. (Del Mar CA), Rapid plunger immunoassay method and apparatus.
  17. Gelfand David H. (Oakland CA) Myers Thomas W. (Emeryville CA), Reverse transcription with thermostable DNA polymerase-high temperature reverse transcription.
  18. West Michael D. (San Carlos CA) Shay Jerry (Dallas TX) Wright Woodring E. (Arlington TX), Telomerase diagnostic methods.
  19. West Michael D. (Belmont CA) Shay Jerry (Dallas TX) Wright Woodring (Arlington TX), Therapy and diagnosis of conditions related to telomere length and/or telomerase activity.
  20. West Michael D. (San Carlos CA) Harley Calvin B. (Palo Alto CA) Strahl Catherine M. (San Francisco CA) McEachern Michael J. (San Francisco CA) Shay Jerry (Dallas TX) Wright Woodring E. (Arlington TX), Therapy and diagnosis of conditions related to telomere length and/or telomerase activity.
  21. Guirguis Raouf A. (Rockville MD), Urine testing apparatus with urinary sediment device.

이 특허를 인용한 특허 (14)

  1. Miller, Donald M.; Bates, Paula J.; Trent, John O., Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin.
  2. Trent, John O.; Bates, Paula J.; Miller, Donald J., Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin.
  3. Miller,Donald M.; Bates,Paula J.; Trent,John O., Antiproliferative activity of g-rich oligonucleotides and method of using same to bind to nucleolin.
  4. Chang, Chien-Wei; Hennessy, Lori K.; Wang, Dennis Y., Method for direct amplification from crude nucleic acid samples.
  5. Chang, Chien-Wei; Hennessy, Lori; Wang, Dennis, Method for direct amplification from crude nucleic acid samples.
  6. Chang, Chien-Wei; Hennessy, Lori; Wang, Dennis, Method for direct amplification from crude nucleic acid samples.
  7. Chang, Chien-Wei; Hennessy, Lori; Wang, Dennis, Method for direct amplification from crude nucleic acid samples.
  8. Chang, Chien-Wei; Wang, Dennis; Hennessy, Lori K., Method for direct amplification from crude nucleic acid samples.
  9. Tsuchiya Masayuki,JPX ; Savoysky Ericka,JPX ; Akamatsu Ken-Ichi,JPX, Method for the quantitative determination of telomerase activity.
  10. Pirot, Zhu Zhen, Method of detecting and assaying telomerase activity of telomerase bound by anti-telomerase antibodies.
  11. Emrich Thomas,DEX ; Leying Hermann,DEX ; Hinzpeter Matthias,DEX ; Karl Gerlinde,DEX, Method of detecting telomerase activity.
  12. Gryaznov, Sergei; Pongracz, Krisztina, Modified oligonucleotides for telomerase inhibition.
  13. Holcomb, Cherie; Higuchi, Russell, SENP1 as a marker for cancer.
  14. Shay Jerry W. ; Wright Woodring E. ; Norton ; Jr. James C., Telomerase extraction method.
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