Compounds having the formula [ STR 1 ] and pharmaceutically acceptable salts thereof wherein X is alkyl, Y is a single bond, --CH.sub.2 --, --C(O)--, --O--, --S-- or --N(R.sup.8)-- where R.sup.8 is hydrogen, alkyl, haloalkyl, aryl, arylalkyl, cycloalkyl or (cycloalkyl)alkyl, and R.sup.1 to R.sup.7 a
Compounds having the formula [ STR 1 ] and pharmaceutically acceptable salts thereof wherein X is alkyl, Y is a single bond, --CH.sub.2 --, --C(O)--, --O--, --S-- or --N(R.sup.8)-- where R.sup.8 is hydrogen, alkyl, haloalkyl, aryl, arylalkyl, cycloalkyl or (cycloalkyl)alkyl, and R.sup.1 to R.sup.7 are as defined herein. These compounds have potassium channel activating activity and are useful, therefore for example, as cardiovascular agents.
대표청구항▼
[ What is claimed is:] [1.] A compound of the formula [ STR 136 ] or pharmaceutically acceptable salts thereof wherein a, b and d are all carbon atoms;Y is a single bond, --O-- or --S--;R.sup.1 is aryl or heterocyclo;R.sup.2 is --COOR.sup.8, --CO-amino, --CO-substituted amino, amino, substituted ami
[ What is claimed is:] [1.] A compound of the formula [ STR 136 ] or pharmaceutically acceptable salts thereof wherein a, b and d are all carbon atoms;Y is a single bond, --O-- or --S--;R.sup.1 is aryl or heterocyclo;R.sup.2 is --COOR.sup.8, --CO-amino, --CO-substituted amino, amino, substituted amino, --NR.sup.8 CO-amino, --NR.sup.8 CO-substituted amino, --NR.sup.8 COR.sup.9, --NR.sup.8 SO.sub.2 R.sup.9, --NR.sup.8 (C.dbd.NCN)-amino, --NR.sup.8 (C.dbd.NCN)-substituted amino, [ STR 137 ] --SR.sup.8, --SOR.sup.8, --SO.sub.2 R.sup.8, --OR.sup.8, cyano, heterocyclo, pyridine-N-oxide, --CH(OR.sup.8).sub.2, [ STR 138 ] (where Z is O or H.sub.2) or [ STR 139 ] R.sup.3 is hydrogen, hydroxy or --OC(O)R.sup.8 ; R.sup.4 and R.sup.5 are each independently hydrogen, alkyl or arylalkyl, or R.sup.4 and R.sup.5 taken together with the carbon atom to which they are attached form a 5- to 7-membered carbocyclic ring;R.sup.6 is hydrogen, alkyl, haloalkyl, alkenyl, alkynyl, cycloalkyl, arylalkyl, (cycloalkyl)alkyl, --CN, --NO.sub.2, --COR.sup.8, --COOR.sup.8, --CONHR.sup.8, --CONR.sup.8 R.sup.9, --CF.sub.3, --S-alkyl, --SOalkyl, --SO.sub.2 alkyl, [ STR 140 ] halogen, amino, substituted amino, --O-alkyl, --OCF.sub.3, --OCH.sub.2 CF.sub.3, --OCOalkyl, --OCONR.sup.8 alkyl, --NR.sup.8 COalkyl, --NR.sup.8 COOalkyl or --NR.sup.8 CONR.sup.9, tetrazolyl, imidazole, oxazole or triazole;R.sup.7 is hydrogen, alkyl, hydroxy, --O-alkyl, amino, substituted amino, --NHCOR.sup.8, --CN or --NO.sub.2 ;R.sup.8 and R.sup.9 are independently hydrogen, alkyl, haloalkyl, aryl, arylalkyl, cycloalkyl or (cycloalkyl)alkyl;X is alkyl; or X-R.sup.2 together can be aryl or heterocyclo when R.sup.1 is heterocyclo; andn is an integer of 1 to 3; provided that when R.sup.1 is aryl, then R.sup.2 is other than --COOR.sup.8, amino, substituted amino, --OR.sup.8 and cyano.
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