Cushman, Darby & Cushman, IP Group of Pillsbury, Madison & Sutro LLP
인용정보
피인용 횟수 :
15인용 특허 :
0
초록▼
The present invention relates to compositions comprising analogues of purine nucleosides containing a ring-expanded ("fat") heterocyclic ring, in place of purine, and an unmodified or modified sugar residue, pharmaceutically acceptable derivatives of such compositions, as well as methods of use ther
The present invention relates to compositions comprising analogues of purine nucleosides containing a ring-expanded ("fat") heterocyclic ring, in place of purine, and an unmodified or modified sugar residue, pharmaceutically acceptable derivatives of such compositions, as well as methods of use thereof. In particular, these compositions may be utilized in the treatment of certain cancers, bacterial, fungal, parasitic, and viral infections, including, but not limited to, Acquired Immunodeficiency Syndrome (AIDS) and hepatitis.
대표청구항▼
[ What is claimed is:] [1.] Potentially planar, aromatic, ring-expanded heterocyclic bases, nucleosides and nucleotide compounds having the structure [ STR 7 ] wherein: R.sub.1, R.sub.3 and R.sub.5 are each independently selected from:NH, NH.sub.2, O, OH, S, and SH;NH-alkyl, N-alkyl, O-alkyl and S-a
[ What is claimed is:] [1.] Potentially planar, aromatic, ring-expanded heterocyclic bases, nucleosides and nucleotide compounds having the structure [ STR 7 ] wherein: R.sub.1, R.sub.3 and R.sub.5 are each independently selected from:NH, NH.sub.2, O, OH, S, and SH;NH-alkyl, N-alkyl, O-alkyl and S-alkyl wherein the alkyl group is C.sub.1 -C.sub.20 ;NH-aryl, O-aryl and S-aryl wherein the aryl group is a substituted or unsubstituted phenyl or heterocyclic group;R.sub.2, R.sub.4, R.sub.7, and R.sub.8 are independently selected from the group consisting of hydrogen, C.sub.1 -C.sub.20 alkyl, substituted phenyl, unsubstituted phenyl, unsubstituted heterocycle, substituted heterocycle, aralkyl wherein the alkyl containing 1 to 6 carbon atoms and the aryl is substituted or unsubstituted;R.sub.6 is selected from the group consisting ofhydrogen,C.sub.1 -C.sub.20 alkyl,substituted phenyl,unsubstituted phenyl,unsubstituted heterocycle,substituted heterocycle,aralkyl wherein the alkyl containing 1 to 6 carbon atoms and the aryl is substituted or unsubstituted:a glycosyl group selected from the group consisting of ribosyl, 2'-deoxyribosyl, 2'3'-dideoxyribosyl, 2'3'-dideoxy-2'-fluororibosyl, 2'3'-dideoxy-3'-fluororibosyl, 2'3'-dideoxy-2'3'-fluororibosyl, 2'3'-dideoxy-3'-azidoribosyl and mono-, di-, and triphosphate derivatives thereof;--(CH.sub.2).sub.m+n+1 --R'--(CH.sub.2).sub.m --O--(CH.sub.2).sub.n --O--R';--(CH.sub.2).sub.m+1 --O--R';--(CH.sub.2).sub.m --O--(CH.sub.2).sub.n --R';wherein R' is selected from the group consisting of: hydrogen, H.sub.2 PO.sub.3, H.sub.3 P.sub.2 O.sub.6, H.sub.4 P.sub.3 O.sub.9, and alkali metal or alkaline earth metal salts thereof;m is zero to 20, n is zero to 20, and a is zero or one;U, X, Y, Z, W, J, K, and L are selected from the group consisting of C and N;and all chiral forms and stereoisomers of said compounds.
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