초록 ▼

The present invention is a method of making discrete particles by subjecting an organic feedstock to liquiflash conditions whereby the feedstock is transformed instantaneously from solid to liquiform to solid. Liquiform is a transient condition wherein the feedstock has substantially unimpeded inter

The present invention is a method of making discrete particles by subjecting an organic feedstock to liquiflash conditions whereby the feedstock is transformed instantaneously from solid to liquiform to solid. Liquiform is a transient condition wherein the feedstock has substantially unimpeded internal flow. Shear force is imparted to the liquiform feedstock in an amount sufficient to separate tiny masses of feedstock. The tiny masses solidify as discretized particles. The present invention also includes unique products resulting from the process, e.g., a monodispersed microsphere product and coated particles prepared therefrom.

대표청구항 ▼

[ What is claimed:] [1.] A medicament comprising monodispersed microspheres of an active agent, each of said microspheres having a solid spherical body with substantially no discontinuity therethrough and having active agent substantially evenly distributed throughout, wherein at least about 80% of

[ What is claimed:] [1.] A medicament comprising monodispersed microspheres of an active agent, each of said microspheres having a solid spherical body with substantially no discontinuity therethrough and having active agent substantially evenly distributed throughout, wherein at least about 80% of the particles have a largest diameter of 60% of the mean diameter and the mean particle size is not greater than 500 microns.