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Macromolecular microparticles and methods of production and use 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C07K-017/02
  • C07K-001/00
  • C08H-001/02
  • G01N-033/544
출원번호 US-0699586 (1996-08-19)
발명자 / 주소
  • Woiszwillo James E.
  • Brown Larry R.
  • Scott Terrence L.
  • Di Jie
  • Sudhalter Judith
  • Blizzard Charles D.
출원인 / 주소
  • Epic Therapeutics, Inc.
대리인 / 주소
    Jones' Askew, LLP
인용정보 피인용 횟수 : 0  인용 특허 : 60

초록 ▼

Microparticles formed by mixing a macromolecule with a polymer at a pH near the isoelectric point of the macromolecule and incubating the mixture in the presence of an energy source for a predetermined length of time. The microparticles are composed of homogeneously distributed, intertwined macromol

대표청구항

[ We claim:] [1.] A microparticle comprising a macromolecule and a polymer in an aqueous solution, wherein the concentration of the macromolecule in the microparticle is at least 40% and less than 100% by weight, and wherein the microparticle does not contain any oil.

이 특허에 인용된 특허 (60)

  1. Okuzumi Yuzi (Belle Mead NJ) Mellon A. Darline (Bridgewater NJ) Wasserman David (Springfield NJ), Addition copolymers of lactide and glycolide and method of preparation.
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  21. Cohen Smadar (Petach-Tickva ILX) Bano Carmen (Valencia PA ESX) Visscher Karyn B. (State College PA) Chow Marie (Brookline MA) Allcock Harry R. (State College PA) Langer Robert S. (Newton MA), Ionically cross-linked polymeric microcapsules.
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  24. Nestor John J. (San Jose CA) Vickery Brian H. (Cupertino CA), Long acting depot injectable formulations for LH-RH analogues.
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  25. Woiszwillo James E. (Milford MA), Macromolecular microparticles and methods of production.
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  26. Yapel ; Jr. Anthony F. (Roseville MN), Magnetically responsive composite microparticle.
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  27. Yen Richard C. K. (4261 Chase Ave. Los Angeles CA 90066), Manufacturing protein microspheres.
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  28. Igari Yasutaka (Hyogo JPX) Saikawa Akira (Osaka JPX) Okamoto Kayoko (Osaka JPX) Kamei Shigeru (Hyogo JPX) Oka Masahisa (Kanagawa JPX) Sano Atsunori (Saitama JPX), Matrix for sustained-release preparation.
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  29. Igari Yasutaka (Hyogo JPX) Saikawa Akira (Osaka JPX) Okamoto Kayoko (Osaka JPX) Kamei Shigeru (Hyogo JPX) Oka Masahisa (Kanagawa JPX) Sano Atsunori (Saitama JPX), Matrix for sustained-release preparation.
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  30. Woiszwillo James E. (Milford MA), Method for isolating biomolecules from a biological sample with linear polymers.
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  36. Kamei Shigeru (Takarazuka JPX) Yamada Minoru (Kawanishi JPX) Ogawa Yasuaki (Ohyamazaki-cho JPX), Method of producing sustained-release microcapsules.
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  45. Itagaki Takaharu (Yokohama JPX) Kusano Hiroshi (Yokohama JPX) Miyata Eiji (Kitakyushu JPX) Tashiro Takayuki (Machida JPX), Porous cross-linked polyvinyl alcohol particles, process for producing the same, and separating agent composed of the sa.
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  46. Illum Lisbeth (The Park GBX) Johnson Olufunmiloyo Lilly (Cambridge MA), Preparation of microparticles.
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  47. Wantier Henri (Dour BEX) Mathieu Fabienne (Nivelles BEX) Baudrihaye Marc (Waterloo BEX) Delacroix Dominique (Kraainem BEX), Preparation of microparticles for controlled release of water-soluble substances.
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  48. Ruiz Jean-Marc (Trelaze FRX), Preparation process of sustained release compositions and the compositions thus obtained.
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  49. Orsolini Piero (Martigny CHX) Heimgartner Frdric (Villeneuve CHX), Process for preparing a pharmaceutical composition.
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  50. Billot Genevieve B. (Lyons FRX) Teichner Marc M. (Sainte Foy Les Lyon FRX), Process for preparing microspheres for the prolonged release of the LHRH hormone and its analogues, microspheres and for.
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  51. Okada Hiroaki (Osaka JPX) Ogawa Yasuaki (Osaka JPX) Yashiki Takatsuka (Hyogo JPX), Prolonged release microcapsule.
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  52. Okada Hiroaki (Suita JPX) Ogawa Yasuaki (Ibaraki JPX) Yashiki Takatsuka (Takarazuka JPX), Prolonged release microcapsule and its production.
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  53. Okada Hiroaki (Osaka JPX) Ogawa Yasuaki (Osaka JPX) Yashiki Takatsuka (Hyogo JPX), Prolonged release microcapsules.
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  54. Okada Hiroaki (Suita JPX) Inoue Yayoi (Kyoto JPX) Ogawa Yasuaki (Otokuni JPX), Prolonged release microcapsules.
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  56. Freeman Amihay (Ben Shemen ILX) Tor Ruth (Kiryat Ono ILX), Stabilized enzymes.
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  57. Yamamoto Masaki (Osaka JPX) Takada Shigeyuki (Osaka JPX) Ogawa Yasuaki (Osaka JPX), Sustained release microcapsule.
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  58. Rasor Ned S. (Cupertino CA) Hilmann Jurgen (Berlin DEX) Lange Lothar (Berlin DEX) Fritzsch Thomas (Berlin DEX) Siegert Joachim (Berlin DEX) Zimmermann Ingfried (Weiler DEX), Ultrasonic contrast medium comprising gas bubbles and solid lipophilic surfactant-containing microparticles and use ther.
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  59. Reid Robert H. (Kensington MD) Boedeker Edgar C. (Chevy Chase MD) van Hamont John E. (Shape MD BEX) Setterstrom Jean A. (Takoma Park MD), Vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompa.
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  60. Gombotz Wayne R. (Lexington MA) Healy Michael S. (E. Bridgewater MA) Brown Larry R. (Newton MA), Very low temperature casting of controlled release microspheres.
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