초록 ▼

It has been discovered that improved yields of engineered tissue following implantation, and engineered tissue having enhanced mechanical strength and flexibility or pliability, can be obtained by implantation, preferably subcutaneously, of a fibrous polymeric matrix for a period of time sufficient

It has been discovered that improved yields of engineered tissue following implantation, and engineered tissue having enhanced mechanical strength and flexibility or pliability, can be obtained by implantation, preferably subcutaneously, of a fibrous polymeric matrix for a period of time sufficient to obtain ingrowth of fibrous tissue and/or blood vessels, which is the removed for subsequent implantation at the site where the implant is desired. The matrix is optionally seeded prior to the first implantation, after ingrowth of the fibrous tissue, or at the time of reimplantation. The time required for fibrous ingrowth typically ranges from days to weeks. The method is particularly useful in making valves and tubular structures, especially heart valves and blood vessels.

대표청구항 ▼

[ We claim:] [1.] A cell-matrix structure comprisinga fibrous matrix formed of a biocompatible, biodegradable synthetic polymer, andseeded with dissociated human cells,wherein the matrix is configured to form a tissue structure having mechanical strength and flexibility or pliability,wherein the cel

[ We claim:] [1.] A cell-matrix structure comprisinga fibrous matrix formed of a biocompatible, biodegradable synthetic polymer, andseeded with dissociated human cells,wherein the matrix is configured to form a tissue structure having mechanical strength and flexibility or pliability,wherein the cell-matrix structure is formed by seeding the matrix, implanting the seeded matrix into a recipient human or animal for a period of time sufficient to form extracellular matrix; and harvesting of the resulting cell-matrix structure.