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특허 상세정보

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Intravaginal drug delivery devices for the administration of 17.beta.-oestradiol precursors

특허상세정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판) A61F-013/00   
미국특허분류(USC) 424/433 ; 424/430 ; 424/422
출원번호 US-0849329 (1997-06-03)
우선권정보 IE-0000247 (1995-04-05)
국제출원번호 PCT/IE95/00063 (1995-12-19)
§371/§102 date 19970603 (19970603)
국제공개번호 WO-9619196 (1996-06-27)
발명자 / 주소
  • McClay Allen,IEX
출원인 / 주소
  • Galen (Chemicals) Limited, IEX
대리인 / 주소
    Maioli
인용정보 피인용 횟수 : 49  인용 특허 : 1
초록
▼

The invention relates to an intravaginal drug delivery device for administration to a female mammal of certain 17.beta.-oestradiol precursors at a substantially constant rate for a period of at least three weeks. The 17.beta.-oestradiol precursor is a 17.beta.-oestradiol moiety in which the, or each, hydroxyl group of the 17.beta.-oestradiol moiety is blocked by a blocking group, which blocking group is readily removed from the 17.beta.-oestradiol in vivo. The 17.beta.-oestradiol precursor must have either a solubility in liquid silicone of not less than...

대표
청구항
▼

[ I claim:] [1.] A cylindrical intravaginal drug delivery device suitable for administration to a female mammal, the device comprising a 17.beta.-oestradiol precursor in a biocompatible hydrophobic elastomeric polymer matrix, the device releasing the 17.beta.-oestradiol precursor in a substantially zero order pattern for at least three weeks, the precursor being a 17.beta.-oestradiol moiety in which the, or each, hydroxyl group of the 17.beta.-oestradiol moiety is blocked by a blocking group, the precursor having sufficient lipophilicity as determined ei...

인용문헌 (1)

  1. Keith Alec D. (Miami FL) Snipes Wallace (State College PA), Polymeric diffusion matrix containing estradiol diacetate.

이 특허를 인용한 특허 (49)

  1. Fleming, William H., Administration of therapeutic or diagnostic agents using interlabial pad.
  2. Alster, Yair; de Juan, Jr., Eugene; Reich, Cary J.; Boyd, Stephen; Sierra, David; Alejandro, Jose D.; Macfarlane, K. Angela; Sutton, Douglas, Anterior segment drug delivery.
  3. Alster, Yair; de Juan, Jr., Eugene; Reich, Cary J.; Boyd, Stephen; Sierra, David; Alejandro, Jose D.; Macfarlane, K. Angela; Sutton, Douglas, Anterior segment drug delivery.
  4. Nicolson, Donald Magnus; Halliday, Janet Anne; Tuominen, Jukka; Zurutuza, Amaia, Bioresorbable polymers.
  5. Devlin, Brid; Holt, Jonathon Daryll; Brimer, Andrew Nathan; Nuttall, Jeremy Peter; Malcolm, Karl; Fetherston, Susan Margaret; Boyd, Peter John James, Combination therapy intravaginal rings.
  6. Fulmer, Mark Thomas; Armbruster, David A.; Frigg, Robert; Gruskin, Elliott A.; Kerr, Sean Hamilton, Drug-impregnated encasement.
  7. Fulmer, Mark Thomas; Armbruster, David A.; Frigg, Robert; Gruskin, Elliott A.; Kerr, Sean Hamilton, Drug-impregnated encasement.
  8. Armbruster, David; Dwyer, James; Chomyn, Jeffrey; Kerr, Sean, Films and methods of manufacture.
  9. Tuominen, Jukka; Zurutuza, Amaia; Livingstone, Mark Alexander; Halliday, Janet Anne, Hydrophilic polyurethane compositions.
  10. Tuominen, Jukka; Zurutuza, Amaia; Livingstone, Mark; Halliday, Janet Anne, Hydrophilic polyurethane compositions.
  11. Lee, Heejin; Duc, Hong Linh Ho; Sansone, Matthew, Implantable device for controlled dissolution and diffusion of low solubility drug.
  12. Lee, Heejin; Cima, Michael J.; Daniel, Karen; Larrivee-Elkins, Cheryl, Implantable device for controlled drug delivery.
  13. Cima, Michael J.; Lee, Heejin, Implantable drug delivery device and methods for treatment of the bladder and other body vesicles or lumens.
  14. Nabahi Shohre,GBX, Intravaginal drug delivery device.
  15. Clare Passmore GB; Claire Gilligan GB, Intravaginal drug delivery devices for the administration of testosterone and testosterone precursors.
  16. Woolfson, David Aaron; Malcolm, Karl, Intravaginal drug delivery devices for the delivery of macromolecules and water-soluble drugs.
  17. Muldoon, Brendan; Lorimer, Colin; Gilligan, Claire, Intravaginal matrix drug delivery devices.
  18. Lee, Heejin; Daniel, Karen; Ho Duc, Hong Linh; Cima, Michael J.; Castillo, Mario; Froelich, Steven; Dimitrakov, Jordan; Kim, Grace Y., Intravesical drug delivery device.
  19. Lee, Heejin; Daniel, Karen; Ho Duc, Hong Linh; Cima, Michael J.; Castillo, Mario; Froelich, Steven; Dimitrakov, Jordan; Kim, Grace Y., Intravesical drug delivery device.
  20. Lee, Heejin; Daniel, Karen Danielle; Ho Duc, Hong Linh; Cima, Michael J.; Castillo, Mario; Froelich, Steven; Dimitrakov, Jordan; Kim, Grace Y., Method for intravesical drug delivery.
  21. Ron, Eyal S.; Langer, Robert S.; Crowley, Jr., William F., Methods and devices for the sustained release of multiple drugs.
  22. Ron, Eyal S.; Langer, Robert S.; Crowley, Jr., William F., Methods and devices for the sustained release of multiple drugs.
  23. Ron, Eyal S.; Langer, Robert S.; Crowley, Jr., William F., Methods and devices for the sustained release of multiple drugs.
  24. Ron, Eyal S.; Langer, Robert S.; Crowley, Jr., William F., Methods and devices for the sustained release of multiple drugs.
  25. Lee, Heejin; Larrivee-Elkins, Cheryl, Methods for intravesical drug delivery and methods and systems for loading devices with drug tablets.
  26. Himes, Julie; Giesing, Dennis; Larrivee-Elkins, Cheryl; Cima, Michael J.; Sarma, Purnanand; Goldenheim, Paul, Methods for sustained treatment of bladder pain and irritative voiding.
  27. de Juan, Jr., Eugene; Alster, Yair; Reich, Cary J.; MacFarlane, K. Angela; Chang, Janelle; Alejandro, Jose D., Ocular insert apparatus and methods.
  28. de Juan, Jr., Eugene; Alster, Yair; Reich, Cary J.; MacFarlane, K. Angela; Chang, Janelle; Boyd, Stephen; Sierra, David; Alejandro, Jose D.; Sutton, Douglas; Gould, Alexander J., Ocular insert apparatus and methods.
  29. de Juan, Jr., Eugene; Alster, Yair; Reich, Cary J.; Macfarlane, K. Angela; Chang, Janelle; Boyd, Stephen; Sierra, David; Alejandro, Jose D.; Sutton, Douglas; Gould, Alexander J., Ocular insert apparatus and methods.
  30. Rubin, Anne Brody; Alster, Yair; Reich, Cary J., Ophthalmic system for sustained release of drug to eye.
  31. Aloba, Oluwole T.; deVries, Tina M., Oral pharmaceutical products containing 17 β-estradiol-3-lower alkanoate, method of administering the same and process of preparation.
  32. Aloba, Oluwole T.; deVries, Tina M, Oral pharmaceutical products containing 17β-estradiol-3-lower alkanoate, method of administering the same and process of preparation.
  33. Aloba, Oluwole T.; deVries, Tina M., Oral pharmaceutical products containing 17β-estradiol-3-lower alkanoate, method of administering the same and process of preparation.
  34. Malcolm, Karl; Woolfson, David; Romano, Joseph, Platinum-catalyzed intravaginal rings.
  35. Malcolm, Karl; Woolfson, David; Romano, Joseph, Platinum-catalyzed intravaginal rings.
  36. Tuominen, Jukka; Zurutuza, Amaia; Livingstone, Mark; Halliday, Janet A., Polyurethane elastomers.
  37. Tuominen, Jukka; Zurutuza, Amaia; Livingstone, Mark; Halliday, Janet Anne, Polyurethane elastomers.
  38. Rodriguez,Gustavo C.; Whitaker,Regina Salas, Prevention of ovarian cancer by administration of a Vitamin D compound.
  39. Gustavo C. Rodriguez ; Regina Salas Whitaker, Prevention of ovarian cancer by administration of a vitamin D compound.
  40. Rodriguez, Gustavo C., Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium.
  41. Rodriguez, Gustavo C., Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium.
  42. Rodriguez Gustavo C., Prevention of ovarian cancer by administration of progestin products.
  43. Rodriguez, Gustavo C., Prevention of ovarian cancer by administration of progestin products.
  44. Robertson, Steven, Stabilised prostaglandin composition.
  45. Robertson, Steven, Stabilised prostaglandin composition.
  46. Robertson, Steven, Stabilised prostaglandin composition.
  47. Halliday, Janet A.; Tuominen, Jukka; Livingstone, Mark; Koppenhagen, Frank; Currie, Lilias; Stewart, Sarah, Water-swellable polymers.
  48. Halliday, Janet A.; Tuominen, Jukka; Livingstone, Mark; Koppenhagen, Frank; Currie, Lilias; Stewart, Sarah, Water-swellable polymers.
  49. Halliday, Janet Anne; Tuominen, Jukka; Livingstone, Mark Alexander; Koppenhagen, Frank; Currie, Lilias Morton; Stewart, Sarah, Water-swellable polymers.

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