초록 ▼

A method of smoothing irregular corneal surfaces and removing protuberances from corneal surfaces by photoablative eximer laser keratectomy is provided. Collagen compositions for use in making collagen modulators useful in photoablative procedures are described. These compositions are applied to irr

A method of smoothing irregular corneal surfaces and removing protuberances from corneal surfaces by photoablative eximer laser keratectomy is provided. Collagen compositions for use in making collagen modulators useful in photoablative procedures are described. These compositions are applied to irregular corneal surfaces in sufficient amounts to at least fill in depressions or other irregularities on a corneal surface and are converted into a modulator, as a gel or polymerized film, prior to photoablation. The collagen modulators facilitate the photoablative smoothing of irregular corneal surfaces and protect adjacent corneal tissue from undesired photoablation.

대표청구항 ▼

[ What is claimed is:] [1.] A method for preparing a solution of neutralized acid soluble collagen having about neutral pH, said method comprising:(i) dialyzing an aqueous solution of acid soluble collagen containing from about 0.025M to about 0.1M of a metal chelating agent and having a pH about 4.

[ What is claimed is:] [1.] A method for preparing a solution of neutralized acid soluble collagen having about neutral pH, said method comprising:(i) dialyzing an aqueous solution of acid soluble collagen containing from about 0.025M to about 0.1M of a metal chelating agent and having a pH about 4.5, wherein said metal chelating agent reduces the amount of calcium, magnesium, sodium, potassium or other metal ion present in said aqueous solution of acid soluble collagen, wherein the pH of solution during dialysis is gradually increased to about 7.0, and(ii) recovering a collagen solution having about neutral pH in which collagen remains in solution at physiological temperatures.