초록 ▼

Graphitic nanotubes, which include tubular fullerenes (commonly called "buckytubes") and fibrils, which are functionalized by chemical substitution, are used as solid supports in electrogenerated chemiluminescence assays. The graphitic nanotubes are chemically modified with functional group biomolec

Graphitic nanotubes, which include tubular fullerenes (commonly called "buckytubes") and fibrils, which are functionalized by chemical substitution, are used as solid supports in electrogenerated chemiluminescence assays. The graphitic nanotubes are chemically modified with functional group biomolecules prior to use in an assay. Association of electrochemiluminescent ruthenium complexes with the functional group biomolecule-modified nanotubes permits detection of molecules including nucleic acids, antigens, enzymes, and enzyme substrates by multiple formats.

대표청구항 ▼

[ What is claimed is:] [8.] A method for performing a binding assay for an analyte of interest present in a sample comprising the steps of:(a) forming a composition containing(i) said sample(ii) a first assay-performance-substance linked to a label compound capable of being induced to luminesce, and

[ What is claimed is:] [8.] A method for performing a binding assay for an analyte of interest present in a sample comprising the steps of:(a) forming a composition containing(i) said sample(ii) a first assay-performance-substance linked to a label compound capable of being induced to luminesce, and(iii) a plurality of functionalized graphitic nanotubes bound to a second assay-performance-substance;(b) incubating said composition to form a complex which includes said graphitic nanotube bound to said second assay-performance-substance and said label compound bound to said first assay-performance-substance;(c) collecting said complex in a measurement zone;(d) inducing the label compound in said complex to luminesce, and(e) measuring the emitted luminescence to measure the presence of the analyte of interest in the sample.