[특허]Affinity membrane system and method of using same

Affinity membrane system and method of using same 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	B01D-061/00 B01D-063/02 A61M-001/34
출원번호	US-0668582 (1996-06-20)
발명자 / 주소	Ofsthun Norma J. Soltys Paul J. Kunas Gretchen A.
출원인 / 주소	Baxter International Inc.
대리인 / 주소	Borecki
인용정보	피인용 횟수 : 19 인용 특허 : 26

초록 ▼

The present invention provides an improved affinity membrane device and method for the effective removal of target molecules in plasma. The affinity membrane device is designed for use in an extracorporeal blood circuit and can be employed concurrently with other therapeutic processes for the purification of blood. The device of the present invention consists of hollow fiber membranes having specified dimensions and transfer properties, ligand immobilized to the pore surface of the hollow fibers, and a housing to encase the hollow fibers and allow appropriate entry and exit of the blood. In a preferred embodiment, specific immobilization chemistries are utilized to attach the ligands to the hollow fibers for optimal function.

대표청구항 ▼

[ We claim:] [9.] A method for the selective removal of targeted molecules present in plasma comprising the steps of:providing a hollow fiber membrane device having (a) an elongated housing with a single inlet port and a single outlet port for entry and exit of blood therefrom; and (b) hollow fibers encased inside the housing, the hollow fibers having pores with suitable pore sizes for separating blood into plasma and cellular components, the hollow fibers having wall thicknesses of about 300 to 3500 microns and having internal diameters of about 70 to 140 microns, the pores having ligands immobilized to an internal surface of the pores with polyethylene glycol having a chain length of about 50 to 250 carbon atoms, the ligands having an affinity for the targeted molecules in plasma;transporting blood into the inlet port of the housing;causing the plasma of the blood to flow into the pores of the hollow fibers by means of positive filtration created by a positive transmembrane pressure near the inlet port while not allowing the cellular components to flow into same;contacting the targeted molecules in the plasma with the ligands for a clinically significant period of time to allow for the binding of the targeted molecules to the ligands; andcausing non-targeted molecules of the plasma to flow back through the pores of the hollow fibers by means of reverse filtration created by a negative transmembrane pressure near the outlet port to reunite the non-targeted molecules with the cellular components of the blood.

이 특허에 인용된 특허 (26)

Watanabe Hiroyuki (Shizuoka JPX) Yokoyama Tadashi (Shizuoka JPX) Yamawaki Naokuni (Shizuoka JPX), Absorbent of b2-microglobulin.
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Hirai Fumiyasu (Amagasaki JPX) Tani Nobutaka (Osaka JPX), Adsorbent for serum amyloid protein.

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Kuroda Toru (Oita JPX) Tohma Norio (Ohno JPX), Adsorber module for whole blood treatment and an adsorber apparatus containing the adsorber module.

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Hou Kenneth C. (Glastonbury CT) Liao Tung-Ping D. (Missouri City TX) Rohan Robert (Columbia CT), Affinity matrices of modified polysaccharide supports.

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Sakamoto Nagayoshi (Ichihara JPX), Body fluid purifying material and method for purifying body fluid by use thereof.

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Furuta ; Tadaaki ; Inagaki ; Kenji ; Mizoguchi ; Yoshiyuki ; Fujikawa ; Noboru ; Kominami ; Naoya, Dialysis unit and dialysis apparatus employing the dialysis unit.

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Bernstein Howard (Cambridge MA) Wheatley Margaret A. (Media PA) Langer Robert S. (Somerville MA), Extracorporeal reactors containing immobilized species.

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Wallace Richard A. (7304 SW. 53 Ave. Portland OR 97219), Hemodialysis assist device.

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Merrill Edward W. (Belmont MA), Immobilized polyethylene oxide star molecules for bioapplications.

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Merrill Edward W. (Belmont MA), Immobilized polyethylene oxide star molecules for bioapplications.

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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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Affinity membrane system and method of using same 원문보기