초록 ▼

A silver implantable medical device 29 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one layer 18 of a bioactive material posited on one surface of structure 12; and at least one porous layer 20 posited

A silver implantable medical device 29 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one layer 18 of a bioactive material posited on one surface of structure 12; and at least one porous layer 20 posited over the bioactive material layer 18 posited on one surface of structure (12) and the bioactive-material-free surface. Also included is a layer or impregnation of silver 45. Preferably, the structure 12 is a coronary stent. The porous layer 20 is comprised of a polymer applied preferably by vapor or plasma deposition and provides a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, merely by condensation of a monomer vapor. Silver is included as a base material, coating or included in a carrier, drug, medicant material utilized with the implantable stent.

대표청구항 ▼

[ What is claimed is:] [25.] An implantable medical device (10), comprising:a structure (12) adapted for introduction into a patient, the structure (12) being composed of a base material (14);at least one layer (18) of a bioactive material posited on at least one surface of the structure (12);at lea

[ What is claimed is:] [25.] An implantable medical device (10), comprising:a structure (12) adapted for introduction into a patient, the structure (12) being composed of a base material (14);at least one layer (18) of a bioactive material posited on at least one surface of the structure (12);at least one porous layer (20) posited over the layer (18) of bioactive material and composed of a polymer to provide for a controlled release of the bioactive material therethrough;an antiproliferative agent selected from the group consisting of elemental silver, silver alloys, silver ions and other silver containing materials and included in or on at least one of said base material, said bioactive material, and said polymer; andat least one additional coating layer (16) between the structure (12) and the at least one bioactive material layer (18);wherein the at least one additional coating layer (16) is less porous than the at least one porous layer (20).