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Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-049/04
  • A61K-009/14
  • A61B-006/00
출원번호 US-0445299 (1995-05-19)
발명자 / 주소
  • Unger Evan C.
출원인 / 주소
  • ImaRx Pharmaceutical Corp.
대리인 / 주소
    Woodcock Washburn Kurtz Mackiewicz & Norris LLP
인용정보 피인용 횟수 : 43  인용 특허 : 155

초록

Novel gas filled microspheres useful as computed tomography (CT) contrast agents. The microspheres are prepared from a gas and/or a gaseous precursor, and one or more stabilizing compounds.

대표청구항

[ What is claimed is:] [1.] A method of providing an image of an internal region of a patient comprising (i) administering to the patient an aqueous composition which comprises gaseous precursor-filled lipid microspheres, (ii) allowing said gaseous precursor to undergo a phase transition from a liqu

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이 특허를 인용한 특허 (43)

  1. Evan C. Unger, Acoustically active drug delivery systems.
  2. Unger,Evan C., Composition comprising low density microspheres.
  3. Unger,Evan C., Composition comprising low density microspheres.
  4. Unger Evan C., Gas filled microspheres as magnetic resonance imaging contrast agents.
  5. Evan C. Unger ; DeKang Shen, Lipid soluble steroid prodrugs.
  6. Robinson, Simon P.; Siegler, Robert W.; Onthank, David C.; Nguyen, Nhung Tuyet, Lipid-encapsulated gas microsphere compositions and related methods.
  7. Schneider, Michel; Yan, Feng; Grenier, Pascal; Puginier, Jerome; Barrau, Marie-Bernadette, Long-lasting aqueous dispersions or suspensions of pressure resistant gas-filled microvesicles and methods for thereof preparation thereof.
  8. Schneider, Michel; Yan, Feng; Garcel, Nadine; Puginier, J?r?me; Barrau, Marie-Bernadette, Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof.
  9. Schneider, Michel; Yan, Feng; Grenier, Pascal; Puginier, Jerome; Barrau, Marie-Bernadette, Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof.
  10. Schneider,Michel; Yan,Feng; Garcel,Nadine; Puginier,Jerome; Barrau,Marie Bernadette; Bussat,Philippe; Hybl,Eva; Bichon,Daniel; Grenier,Pascal, Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof.
  11. Unger, Evan C., Low density microspheres and their use as contrast agents for computed tomography and in other applications.
  12. Wang, Chung-Hsin, Method and device for producing optimized lipid-based micro/nano-bubbles.
  13. Hall Christopher S. ; Hughes Michael S., Method for calibrating ultrasound devices and contrast agents and system therefor.
  14. Unger Evan C., Method of computed tomography using fluorinated gas-filled lipid microspheres as contract agents.
  15. Evan C. Unger, Method of magnetic resonance focused surgical and therapeutic ultrasound.
  16. Evan C. Unger ; Thomas A. Fritz ; Terry Matsunaga ; VaradaRajan Ramaswami ; David Yellowhair ; Guanli Wu, Method of preparing gas and gaseous precursor-filled microspheres.
  17. Unger, Evan C.; McCreery, Thomas, Methods for delivering compounds into a cell.
  18. Unger, Evan C.; McCreery, Thomas, Methods for delivering compounds into a cell.
  19. Unger, Evan C.; McCreery, Thomas, Methods for delivering compounds into a cell.
  20. Unger, Evan C., Methods for diagnostic imaging involving the use of a contrast agent and a coronary vasodilator.
  21. Robinson, Simon P.; Siegler, Robert W.; Nguyen, Nhung Tuyet; Onthank, David C.; Anklekar, Tarakeshwar Vishwanath; Van Kirk, Charles Chester, Methods for making ultrasound contrast agents.
  22. Robinson, Simon P.; Siegler, Robert W.; Nguyen, Nhung Tuyet; Onthank, David C.; Anklekar, Tarakeshwar Vishwanath; Van Kirk, Charles Chester, Methods for making ultrasound contrast agents.
  23. Robinson, Simon P.; Siegler, Robert W.; Nguyen, Nhung Tuyet; Onthank, David C.; Anklekar, Tarakeshwar Vishwanath; Van Kirk, Charles Chester, Methods for making ultrasound contrast agents.
  24. Unger Evan C. ; Fritz Thomas A. ; Gertz Edward W., Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same.
  25. Unger,Evan C.; Wu,Yunqiu, Methods of imaging and treatment.
  26. Unger, Evan C.; Wu, Yunqiu, Methods of imaging and treatment with targeted compositions.
  27. Schneider, Michel; Yan, Feng; Garcel, Nadine; Puginier, Jerome; Barrau, Marie-Bernadette; Bussat, Philippe; Hybl, Eva; Bichon, Daniel, Mixable combination for generating a suspension of stable microbubbles for ultrasonic imaging.
  28. Unger, Evan C., Non-invasive methods for surgery in the vasculature.
  29. Rychak, Joshua J., Optical imaging contrast agents and uses thereof.
  30. Unger, Evan C.; McCreery, Thomas; Wu, Yunqiu, Oxygen delivery agents and uses for the same.
  31. Unger,Evan C.; McCreery,Thomas; Wu,Yunqiu, Oxygen delivery agents and uses for the same.
  32. Hui, Poh K.; Bishop, John E.; Madrigal, Jr., Eleodoro S., Preparation of a lipid blend and a phospholipid suspension containing the lipid blend.
  33. Hui, Poh K.; Bishop, John E.; Madrigal, Jr., Eleodoro S., Preparation of a lipid blend and a phospholipid suspension containing the lipid blend.
  34. Hui, Poh K.; Bishop, John E.; Madrigal, Jr., Eleodoro S., Preparation of a lipid blend and a phospholipid suspension containing the lipid blend.
  35. Hui, Poh K.; Bishop, John E.; Madrigal, Jr., Eleodoro S., Preparation of a lipid blend and a phospholipid suspension containing the lipid blend.
  36. Evan C. Unger ; Dekang Shen ; Guanli Wu, Silicon amphiphilic compounds and the use thereof.
  37. Unger,Evan C.; Matsunaga,Terry O.; Schumann,Patricia A., Targeted compositions for diagnostic and therapeutic use.
  38. Evan C. Unger ; Thomas A. Fritz ; Terry Matsunaga ; VaradaRajan Ramaswami ; David Yellowhair ; Guanli Wu, Therapeutic delivery systems.
  39. Unger,Evan C.; Fritz,Thomas A.; Matsunaga,Terry; Ramaswami,VaradaRajan; Yellowhair,David; Wu,Guanli, Therapeutic delivery systems.
  40. Schneider, Michel; Yan, Feng; Grenier, Pascal; Puginier, Jerome; Barrau, Marie-Bernadette; Bussat, Philippe; Hybl, Eva; Bichon, Daniel, Ultrasound contrast agents and methods of making and using them.
  41. Schneider,Michel; Yan,Feng; Garcel, legal representative,Nadine; Puginier,Jerome; Barrau,Marie Bernadette; Bussat,Philippe; Hybl,Eva; Bichon,Daniel; Grenier, deceased,Pascal, Ultrasound contrast agents and methods of making and using them.
  42. Schneider,Michel; Yan,Feng; Gercel, legal representative,Nadine; Puginier,Jerome; Barrau,Maria Bernadette; Bussat,Philippe; Hybl,Eva; Bichon,Daniel; Grenier, deceased,Pascal, Ultrasound contrast agents and methods of making and using them.
  43. Unger,Evan C., Ultrasound imaging and treatment.
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