초록 ▼

Improved aerodynamically light particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the aerodynamically light particles are made of a biodegradable material and have a tap density less than 0.4 g/cm.sup.3 and

Improved aerodynamically light particles for drug delivery to the pulmonary system, and methods for their synthesis and administration are provided. In a preferred embodiment, the aerodynamically light particles are made of a biodegradable material and have a tap density less than 0.4 g/cm.sup.3 and a mass mean diameter between 5 .mu.m and 30 .mu.m. The particles may be formed of biodegradable materials such as biodegradable polymers. For example, the particles may be formed of a functionalized polyester graft copolymer consisting of a linear .alpha.-hydroxy-acid polyester backbone having at least one amino acid group incorporated therein and at least one poly(amino acid) side chain extending from an amino acid group in the polyester backbone. In one embodiment, aerodynamically light particles having a large mean diameter, for example greater than 5 .mu.m, can be used for enhanced delivery of a therapeutic agent to the alveolar region of the lung. The aerodynamically light particles incorporating a therapeutic agent may be effectively aerosolized for administration to the respiratory tract to permit systemic or local delivery of wide variety of therapeutic agents.

대표청구항 ▼

[ What is claimed is:] [1.] A particulate composition for drug delivery to the pulmonary system comprising:biodegradable particles for delivery of a therapeutic, prophylactic or diagnostic agent, wherein the particles have a tap density less than 0.4 g/cm.sup.3, at least approximately 90% of the par

[ What is claimed is:] [1.] A particulate composition for drug delivery to the pulmonary system comprising:biodegradable particles for delivery of a therapeutic, prophylactic or diagnostic agent, wherein the particles have a tap density less than 0.4 g/cm.sup.3, at least approximately 90% of the particles have a mass mean diameter between 5 .mu.m and 30 .mu.m, the aerodynamic diameter of the particles is between one and three microns, the particles are suitable for delivery to the deep lung, and a therapeutic, prophylactic or diagnostic agent is incorporated into or adsorbed onto the biodegradable particles.