초록 ▼

Antibodies, including monoclonal antibodies, specific for proliferating/angiogenic human endothelial cells such as human umbilical vein endothelial cells and human umbilical artery endothelial cells, and conjugates of these antibodies with a toxin material or label, are useful for inhibition of angi

Antibodies, including monoclonal antibodies, specific for proliferating/angiogenic human endothelial cells such as human umbilical vein endothelial cells and human umbilical artery endothelial cells, and conjugates of these antibodies with a toxin material or label, are useful for inhibition of angiogenesis or for treatment of angiogenesis-dependent disease.

대표청구항 ▼

[ I claim:] [1.] A therapeutic composition for inhibition of tumor associated angiogenesis or for treatment of tumor associated angiogenesis, selected from the group consisting essentially of:i. an antibody which specifically binds proliferating human endothelial cells, said antibody binding prolife

[ I claim:] [1.] A therapeutic composition for inhibition of tumor associated angiogenesis or for treatment of tumor associated angiogenesis, selected from the group consisting essentially of:i. an antibody which specifically binds proliferating human endothelial cells, said antibody binding proliferating human endothelial cells selected from the group consisting of proliferating human umbilical vein endothelial (HUVE) cells and human umbilical artery endothelial (HUAE) cells and not binding cells selected from the group consisting of non-proliferating HUVE cells and non-proliferating HUAE cells, andii. an antibody-conjugate comprising an antibody and a conjugate material, said antibody of said antibody-conjugate being an antibody which specifically binds proliferating human endothelial cells, said antibody binding proliferating human endothelial cells selected from the group consisting of proliferating human umbilical vein endothelial (HUVE) cells and human umbilical artery endothelial (HUAE) cells and not binding cells selected from the group consisting of non-proliferating HUVE cells and non-proliferating HUAE cells, and said conjugate material being selected from the group consisting of a toxin material and a detectable label;together with a pharmaceutically acceptable carrier.