Combinations, called matrices with memories, of matrix materials with remotely addressable or remotely programmable recording devices that contain at least one data storage unit are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical synthese
Combinations, called matrices with memories, of matrix materials with remotely addressable or remotely programmable recording devices that contain at least one data storage unit are provided. The matrix materials are those that are used in as supports in solid phase chemical and biochemical syntheses, immunoassays and hybridization reactions. The data storage units are non-volatile antifuse memories or volatile memories, such as EEPROMS, DRAMS or flash memory. By virtue of this combination, molecules and biological particles, such as phage and viral particles and cells, that are in proximity or in physical contact with the matrix combination can be labeled by programming the memory with identifying information and can be identified by retrieving the stored information. Combinations of matrix materials, memories, and linked molecules and biological materials are also provided. The combinations have a multiplicity of applications, including combinatorial chemistry, isolation and purification of target macromolecules, capture and detection of macromolecules for analytical purposes, selective removal of contaminants, enzymatic catalysis, cell sorting, drug delivery, chemical modification and other uses. Methods for electronically tagging molecules, biological particles and matrix support materials, immunoassays, receptor binding assays, and other methods are also provided.
대표청구항▼
[ What is claimed:] [1.] A combination of a matrix with memory, comprising:(A) a recording device, comprising memory means containing a data storage unit; and(B) a matrix, wherein:the matrix is either comprised of particles of a size such that at least one dimension is no more than 100 mm or the mat
[ What is claimed:] [1.] A combination of a matrix with memory, comprising:(A) a recording device, comprising memory means containing a data storage unit; and(B) a matrix, wherein:the matrix is either comprised of particles of a size such that at least one dimension is no more than 100 mm or the matrix is in the form of a container selected from the group consisting of vials, test tubes, culture dishes, vessels of a volume of about 100 ml or less, and microtiter plates or is in the form of a continuous surface that encases the recording device; andthe recording device, further comprises:reaction verifying means, comprising a sensor means which senses an energy release during a reaction and generates an electrical signal in response thereto.
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