초록 ▼

Biodegradable, porous, polymeric implant material provides substantially continuous release of bioactive agent during in vivo use. Bioactive agent is initially released in amounts that are less than degradation rate of polymer, thereby promoting migration of cells into material. Later larger amounts

Biodegradable, porous, polymeric implant material provides substantially continuous release of bioactive agent during in vivo use. Bioactive agent is initially released in amounts that are less than degradation rate of polymer, thereby promoting migration of cells into material. Later larger amounts of bioactive agent are released, thereby promoting differentiation of cells. Method of making material includes steps of applying vacuum temperature and consession to form pores. Implant material may be adapted for one phase implant (e.g., for bone or cartilage) or for two phase layered implant (e.g., for cartilage layer on top of bone layer).

대표청구항 ▼

[ We claim:] [1.] A porous bioerodible tissue implant device comprising a bioerodible synthetic polymeric material having a uniform non-fibrous composition characterized in that said material has a predetermined uniform porosity and is adapted to be implanted during use into cartilage, said polymeri

[ We claim:] [1.] A porous bioerodible tissue implant device comprising a bioerodible synthetic polymeric material having a uniform non-fibrous composition characterized in that said material has a predetermined uniform porosity and is adapted to be implanted during use into cartilage, said polymeric material having the stiffness and compressibility properties of said cartilage.