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Immunochromatographic assay device

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • G01N-033/558
출원번호 US-0040430 (1993-03-31)
발명자 / 주소
  • Chandler Howard M.
  • Piasio Roger N.
  • Prouty Karen
출원인 / 주소
  • SmithKline Diagnostics, Inc.
대리인 / 주소
    May
인용정보 피인용 횟수 : 71  인용 특허 : 356

초록

A chromatographic assay device for use with immunoassays allows rapid and convenient assays of analytes of biological interest, and permits extractions to be carried out in situ, avoiding the use of separate extraction vessels. The device has a wide dynamic range and avoids interference from particu

대표청구항

[ We claim:] [1.] A chromatographic assay device for detection or determination of an analyte in a sample comprising:(a) a first opposable component including:(i) a chromatographic medium having first and second ends and a detection zone, the chromatographic medium having a reagent bound at the dete

이 특허에 인용된 특허 (356)

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  176. Renn Donald W. (Glen Cove ME MA) Saravis Calvin A. (Waban MA), Medium for use in bioassay and method of using same.
  177. Hay-Kaufman Martha L. (Los Altos CA) Becker Rosette (Palo Alto CA) Danisch Robert (Fremont CA), Membrane assay using focused sample application.
  178. Clemmons Roger M. (Gainesville FL), Membrane-strip reagent serodiagnostic apparatus and method.
  179. Yen Shiao-Ping S. (Altadena CA) Rembaum Alan (Altadena CA) Molday Robert S. (Vancouver CAX), Metal containing polymeric functional microspheres.
  180. Cole Francis X. (Stow MA) Davis Gene (Lexington MA) Sigillo Eric (Meuthen MA), Metal sol capture immunoassay procedure, kit for use therewith and captured metal containing composite.
  181. Leuvering Johannes H. W. (Heesch NLX), Metal sol particle immunoassay.
  182. Sodickson Lester A. (Newton MA) Lim Franklin (Richmond VA), Method and apparatus for chemical spot test analysis.
  183. Giaever Ivar (Schenectady NY), Method and apparatus for detection of antibodies and antigens.
  184. Valkirs Gunars E. (San Marcos CA) Owen Newton C. (Encinitas CA) Levinson Philip A. (San Diego CA), Method and apparatus for immunoassays.
  185. Valkirs Gunars E. (San Marcos CA) Owen Newton C. (Encinitas CA) Levinson Philip A. (San Diego CA), Method and apparatus for immunoassays.
  186. Friend William G. (9039 SE. 59th Mercer Island WA 98040), Method and apparatus for occult blood testing in the home.
  187. Piasio Roger N. (Yarmouth ME) Perry David A. (Portland ME) Nayak Pangal N. (Yarmouth ME), Method and apparatus for performing in vitro clinical diagnostic tests using a solid phase assay system.
  188. Ruhenstroth-Bauer Gerhard (Grafelfing DT) Scherer Reiner (Munich DT), Method and apparatus for simultaneous quantitative analysis of several constituents in a sample.
  189. Roper Michael D. (Lafayette CO), Method and article for detection of immune complexes.
  190. Baker Josefina T. (Cupertino CA) Pagano Joseph F. (Paoli PA) Schoengold Ronald J. (San Jose CA), Method and device for collecting and testing for fecal occult blood.
  191. Milligan Terry W. (Belmont MA) Wright Richard F. (Acton MA), Method and device for determining the concentration of a substance in a fluid.
  192. McGeehan John K. (Woodbury NJ) Ertingshausen Gerhard (Princeton NJ), Method and device for metering of fluid samples and detection of analytes therein.
  193. Pucci Alessandra (Sydney AUX) Smithyman Antony M. (Sydney AUX) Slade Martin B. (Sydney AUX) French Peter W. (Sydney AUX) Wijffels Gene (Sydney AUX), Method and diagnostic aid for detecting occult faecal blood.
  194. Hari V. (Bloomfield Hills MI) Baunoch David A. (Pontiac MI) Das Pritam (Detroit MI), Method for detecting the presence of antibodies using gold-labeled antibodies and test kit.
  195. Buck Harvey (Indianapolis IN), Method for determining an analyte in a liquid sample using a zoned test device and an inhibitor for a label used in said.
  196. Brenneman Allen J. (Elkhart IN), Method for distributing and analyzing a fluid sample onto a test surface.
  197. Skold Carl N. (Mountain View CA) Shanafelt Armen B. (Redwood City CA) Ghazarossian Vartan (Menlo Park CA) Ullman Edwin F. (Atherton CA), Method for immunochromatographic analysis.
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  199. Hiratsuka Nobuo (Tokyo JPX) Mihara Yuji (Minami-ashigarashi JPX) Masuda Nobuhito (Minami-ashigarashi JPX) Miyazako Takushi (Minami-ashigarashi JPX), Method for immunological assay using multilayer analysis sheet.
  200. Liotta Lance A. (14004 Mont Ave. East Cleveland OH 44112), Method for isolating bacterial colonies.
  201. Bacquet, Cathy A.; Twumasi, Daniel Y., Method for ligand determination utilizing an immunoassay monitorable by biotin-containing enzymes, and compositions therefor.
  202. Bolz Gunner (Santa Clara CA) Deindoerfer Fred H. (Northridge CA) Hu Chun P. (Santa Clara CA) Kameda Naomi (Foster City CA) Wang Robert (San Jose CA), Method for quantitation of antigens or antibodies on a solid surface.
  203. Ertinghausen Gerhard (Princeton NJ), Method for quantitative analysis of body fluid constituents.
  204. Jonsson U. R. Svante (Lund SEX), Method for the detection of antibodies.
  205. Mallener Werner (Dsseldorf DEX) Overhoff Theodor (Niederzier DEX), Method of and device for the reduction of reactivity of a nuclear reactor core.
  206. Bornstein Irene (Skokie IL) Kapsalis Andreas A. (Northfield IL), Method of detecting antigens or antibodies.
  207. Reunanen Matti Antero (Kupittaankatu 11-13 C 38 20520 Turku 52 SF), Method of radioimmunoassay employing diffusion.
  208. Aunet Diane L. (Waukegan IL) Gerogevich Gradimir G. (Mundelein IL) Jeng Tzyy-Wen (Vernon Hills IL) Oosta Gary M. (Gurnee IL) Siegel Neal A. (Deerfield IL), Methods and devices for the separation of plasma or serum from whole blood.
  209. Hevey Richard C. (Rockport ME) Malmros Mark K. (Newton PA), Methods for the detection and determination of ligands.
  210. Kereluk ; Karl, Microbiological scaled sterility test strips and method.
  211. Graas Joseph E. (10527 Caminito Glenellen San Diego CA 92126), Microchromatographic device and method for rapid determination of a desired substance.
  212. Snyder Brian A. (Rochester NY) Grogan Elizabeth A. (Rochester NY) Sutton Richard C. (Rochester NY), Microporous article having a stabilized specific binding reagent, a method for its use and a diagnostic test kit.
  213. Zuk Robert F. (Burlingame CA) Armenta Richard D. (Sunnyvale CA) Briggs Jonathan (Los Altos Hills CA), Migratory detection immunoassay.
  214. Allen Michael P. (Sunnyvale CA) Jeong Henry J. (Palo Alto CA), Mobile reagents in an analyte assay in a self-contained apparatus.
  215. Ward David C. (Guilford CT) Langer Pennina R. (Monsey NY) Waldrop ; III Alexander A. (Charlottesville VA), Modified nucleotides and methods of preparing and using same.
  216. Columbus Richard L. (Rochester NY), Multi-analyte test device.
  217. Kuhn Raymond E. (Clemmons NC) MacDonald Gene H. (Greensboro NC), Multi-layered test card for the determination of substances in liquids.
  218. Uo Junko (Kyoto JPX) Nishimura Masaji (Kyoto JPX) Horiguchi Kazuo (Kyoto JPX) Nakanishi Setsuko (Kyoto JPX) Kaku Shigeru (Kyoto JPX), Multi-spot enzyme immunoassay method.
  219. Hill Doyle E. (Fairport NY) Sanford Karl J. (Rochester NY), Multi-zone analytical element and method using same.
  220. Columbus Richard L. (Rochester NY), Multi-zoned reaction vessel having pressure-actuatable control means between zones.
  221. Akiyoshi Yutaka (Saitama JPX) Kondo Asaji (Saitama JPX) Kitajima Masao (Saitama JPX), Multilayer analysis element.
  222. Bruschi ; Barbara J., Multilayer analytical element.
  223. Bruschi Barbara J. (Olathe KS), Multilayer analytical element.
  224. Walter Bert (South Bend IN), Multilayer analytical element having an impermeable radiation diffusing and blocking layer.
  225. Greenquist Alfred C. (Elkhart IN), Multilayer analytical element having an impermeable radiation nondiffusing reflecting layer.
  226. Kondo Asaji (Saitama JPX), Multilayer chemical analysis member having an outer waterproof layer.
  227. Feingers Judith (Jerusalem ILX) Pick Anthony J. (Jerusalem ILX) Wagner Daniel B. (Jerusalem ILX), Multilayer column chromatography specific binding assay method, test device and test kit.
  228. Berke Carl M. (Cambridge MA), Multilayer element for analysis.
  229. Greenquist Alfred C. (Elkhart IN) Li Thomas M. (Elkhart IN) Rupchock Patricia A. (Elkhart IN) Tyhach Richard J. (Elkhart IN) Walter Bert (South Bend IN), Multilayer homogeneous specific binding assay device.
  230. Chan Emerson W. (Libertyville IL) Schulze Werner (Waukegan IL) Robey William G. (Libertyville IL) Braun Brian P. (Gurnee IL) Daluga Cynthia K. (Lindenhurst IL) Kapsalis Andreas A. (Evanston IL) Knigg, Multilayer solid phase immunoassay support and method of use.
  231. Deneke Ulfert (Rimbach-Zotzenbach DEX) Nagel Rolf (Brstadt DEX) Rothe Anselm (Birkenau DEX) Freitag Helmut (Weinheim DEX), Multilayer test strip device with a dissolvable reagent layer.
  232. Kondo Asaji (Asaka JPX) Kitajima Masao (Asaka JPX), Multilayered integral chemical analysis element for the blood.
  233. Kitajima Masao (Osaka JPX) Arai Fuminori (Osaka JPX) Kondo Asaji (Osaka JPX), Multilayered integral element for the chemical analysis of the blood.
  234. Fenocketti Leonard P. (Tolland CT) Rapkin Myron C. (Elkhart IN), Multilayered test device for determining the presence of a liquid sample component, and method of use.
  235. Dafforn Geoffrey A. (Los Altos CA) Kurn Nurith (Palo Alto CA) Becker Martin (Palo Alto CA) Ullman Edwin F. (Atherton CA), Multiple port assay device.
  236. Bahar Izak (Chestnut Hill MA) Cole Francis (Stow MA), Multiple-antibody detection of antigen.
  237. White ; William I., Multisystem test means.
  238. Greenquist Alfred C. (Elkhart IN), Multizone analytical element having detectable signal concentrating zone.
  239. Greenquist Alfred C. (Elkhart IN), Multizone analytical element having labeled reagent concentration zone.
  240. Allen Michael P. (Sunnyvale CA) Jeong Henry J. (Palo Alto CA), Non-instrumented cholesterol assay.
  241. Fan Eugene (La Jolla CA) Chen Fon-Chiu M. (San Diego CA) Milner Michael W. (San Diego CA) Rehg Leslie J. (San Diego CA), Occult blood sampling device and assay.
  242. Giaever Ivar (Schenectady NY), Opaque layer method for detecting biological particles.
  243. Coleman Patrick F. (Poway CA) Maggio Edward T. (San Diego CA), Orthogonal flow immunoassays and devices.
  244. Pawlowski Thomas D. (Neenah WI), Packaging.
  245. Mennen ; Frederick C., Paper booklet for presumptive diagnosis of Neisseria Gonorrhoeae in the male.
  246. Dole Charles M. (Purdys NY) Webster Gary L. (Fairfield CT), Personal diagnostic kit.
  247. Niimura Toshinobu (Mineola NY) Takahashi Tadashi (Port Washington NY) Kashiba Mutsuro (Williston Park NY) Sakai Ko (Hew Hyde Park NY) Kano Tokio (Bellerose NY), Plate substrate immunoassay device and method for performing a multi-test immunoassay on a specimen.
  248. Cole Francis X. (Stow MA) Sigillo Eric C. (Methuen MA) MacDonnell Paul C. (Bedford MA) Cicia Nancy J. (Wakefield MA), Porous strip form assay device method.
  249. Bahar Izak (Chestnut Hill MA), Positive step immunoassay.
  250. Litman David J. (Palo Alto CA) Ullman Edwin F. (Atherton CA), Preferential signal production on a surface in immunoassays.
  251. Banik ; Upendra K. ; Givner ; Morris L., Pregnancy test.
  252. Greenquist Alfred C. (Elkhart IN) Rupchock Patricia A. (Elkhart IN) Tyhach Richard J. (Elkhart IN) Walter Bert (South Bend IN), Preparing homogeneous specific binding assay element to avoid premature reaction.
  253. Skare Helge (Heggtoppen ; P.O. Box 8 3401 Lierbyen NO) Hirschberg Henry (Studentbyen pa Kringsja Sognsveien 218 ; Oslo 8 NO), Procedure and means for collecting liquid containing radioactive tracer elements.
  254. Davis Paul J. (Bedfordshire GB2) Porter Philip (Bedford GB2), Process and apparatus for carrying out specific binding assays.
  255. Vogel Peter (Hemsbach DEX) Braun Hans-Peter (Hemsbach DEX) Berger Dieter (Viernheim DEX) Werner Wolfgang (Mannheim DEX), Process and composition for separating plasma or serum from whole blood.
  256. Koenhen Dirk M. (Enschede NLX) Scharstuhl Johan J. (Hengelo NLX), Process and device for the separation of a body fluid from particulate materials.
  257. Rothe Anselm (Birkenau DEX) Selle Adolf K. (Birkenau DEX) Lange Hans-Rudolf (Lampertheim DEX) Rittersdorf Walter (Mannheim DEX) Werner Wolfgang (Mannheim DEX), Process and diagnostic device for the determination of ammonia and of substrates which react with the formation of ammon.
  258. Klose Sigmar (Berg DEX) Sthler Fritz (Tutzing DEX), Process for carrying out analytical determinations and means for carrying out this process.
  259. Ching Shanfun (Libertyville IL) Billing Patricia (Gurnee IL) Gordon Julian (Lake Bluff IL), Process for immunochromatography with colloidal particles.
  260. Pernice Walter (Marburg an der Lahn DEX) Sedlacek Hans-Harald (Marburg an der Lahn DEX), Process for immunologic determination tests.
  261. Schuurs Antonius H. W. M. (Oss NLX) van Weemen Bauke K. (Oss NLX), Process for the demonstration and determination of reaction components having specific binding affinity for each other.
  262. McFarland Edward (Baltimore MD) Uithoven Keith (West Friendship MD) Carlson Jeffrey (Mountain View CA), Process, test device, and test kit for a rapid assay having a visible readout.
  263. Cohen Marvin D. (9251 Burdine ; No. 297 Houston TX 77016), Pumicite filter aid.
  264. Litman David J. (Los Altos CA) Li Thomas M. (Milpitas CA) Buelteman Laura L. (San Jose CA) Wong Emmy T. (Los Alto Hills CA), Qualitative immunochromatographic method and device.
  265. Litman David J. (Los Altos CA) Li Thomas M. (Milpitas CA) Buelteman Laura L. (San Jose CA) Wong Emmy T. (Los Altos Hills CA), Qualitative immunochromatographic method and device.
  266. Litman David J. (Los Altos CA) Li Thomas M. (Milpitas CA) Buelteman Laura L. (San Jose CA) Wong Emmy T. (Los Altos Hills CA), Qualitative immunochromatographic method and device.
  267. Swanson Melvin J. (Carver MN) Guire Patrick E. (Eden Prairie MN), Quantitative analysis apparatus and method.
  268. Messenger Lowry J. (Granger IN) Nelson Christine D. (Edwardsburg MI) Yip Kin-Fai (Elkhart IN) Wogoman Frank W. (Granger IN), Reaction cassette for preforming sequential analytical assays by noncentrifugal and noncapillary manipulations.
  269. Oberhardt Bruce (Raleigh NC), Reaction system element and method for performing prothrombin time assay.
  270. Farina Peter R. (North Salem NY) Ordonez Kathy P. (Peekskill NY) Siewers Iris J. (White Plains NY), Reactor/separator device for use in automated solid phase immunoassay.
  271. Maggio Edward T. (Redwood City CA) Wife Richard L. (Sittingbourne CA GB2) Ullman Edwin F. (Atherton CA), Reagents and method employing channeling.
  272. Rubenstein ; Kenneth E. ; Leute ; Richard K., Receptor steric hindrance immunoassay for receptor determination.
  273. Woodrum David L. (Rancho Palos Verdes CA), Reversible immobilization of assay reagents in a multizone test device.
  274. Kelton Arden A. (Westminster CA) Bell Michael L. (Corona CA) Chung Roy A. (Fountain Valley CA), Rotary fluid manipulator.
  275. Kelton Arden A. (Westminster CA) Bell Michael L. (Corona CA) Chung Roy A. (Fountain Valley CA), Rotary fluid manipulator.
  276. Clark Phillip (Stoneham MA), Sample collection and analytical device.
  277. Halbert Seymour P. (Miami FL) Anken Milton (N. Miami Beach FL), Sandwich EIA for antigen.
  278. Halbert Seymour P. (Miami FL) Anken Milton (N. Miami Beach FL), Sandwich EIA for antigen associated with hepatitis.
  279. Gubinski Julian (Jamison PA) Palmer John L. (Philadelphia PA), Sealing device and method for inhibition of flow in capillary measuring devices.
  280. Grenner Gerd (Lincoln MA), Self contained immunoassay element.
  281. Osikowicz Eugene W. (Lake Zurich IL) Beggs Michael (Waukegan IL) Brookhart Paul (Gurnee IL) Richerson Russell B. (Lake Zurich IL) Walsworth Frank (Gurnee IL), Self-performing immunochromatographic device.
  282. Intengan Franklin S. (Hialeah FL), Self-stacking reagent slide.
  283. Friesen Heinz-Jrgen (Marburg DEX) Grenner Gerd (Marburg DEX) Pauly Hans-Erwin (Dautphetal DEX) Kohl Helmut (Wetter DEX) Habenstein Klaus (Wetter DEX) Strk Joseph (Ebsdorfergrund DEX), Sheet-like diagnostic device.
  284. Litman David J. (Mountain View CA) Ullman Edwin F. (Atherton CA), Simultaneous calibration heterogeneous immunoassay.
  285. Litman David J. (Mountain View CA) Ullman Edwin F. (Atherton CA), Simultaneous calibration heterogeneous immunoassay.
  286. Litman David J. (Mountain View CA) Ullman Edwin F. (Atherton CA), Simultaneous calibration heterogeneous immunoassay.
  287. Litman, David J.; Ullman, Edwin F., Simultaneous calibration heterogeneous immunoassay.
  288. Leeder Sydney (Union City CA) Zuk Robert F. (Menlo Park CA), Single step heterogeneous assay.
  289. Devaney ; Jr. Mark J. (Rochester NY) Wannenwetsch Edward H. (Rochester NY), Sliding test device for assays.
  290. Ditlow Charles C. (Brockton) Cannon L. Edward (Wayland) Cole Francis X. (Stow) Davis Gene A. (Lexington) Sigillo Eric C. (Meuthen) Danti Alicia G. (Billerica MA), Sol capture immunoassay kit and procedure.
  291. Campbell Robert L. (Durham NC) Wagner Daniel B. (Raleigh NC) O\Connell James P. (Chapel Hill NC), Solid phase assay.
  292. Rosenstein Robert W. (Elliott City MD) Bloomster Timothy G. (Reisterstown MD), Solid phase assay employing capillary flow.
  293. Campbell Robert L. (Durham NC) Wagner Daniel B. (Raleigh NC) O\Connell James P. (Chapel Hill NC), Solid phase assay with visual readout.
  294. Hersh Leroy S. (Painted Post NY) Yaverbaum Sidney (Big Flats NY), Solid phase radioimmunoassay of digoxin.
  295. Giegel Joseph L. (Miami FL) Brotherton Mary M. (Miami FL), Solid phase system for ligand assay.
  296. Giegel Joseph L. (Miami FL) Brotherton Mary M. (Miami FL), Solid phase system for ligand assay.
  297. Brown ; III William E. (Grayslake IL) Safford Sarah E. (Libertyville IL) Clemens John M. (Gurnee IL), Solid-phase analytical device and method for using same.
  298. Schick Lloyd A. (Elkhart IN) Carpenter Stephen K. (Elkhart IN), Specific binding - adsorbent assay method and test means.
  299. Cais Michael (Haifa ILX), Specific binding assay method and reagent means.
  300. Hornby William E. (Bray GB2) Morris David L. (Stoke Poges GB2), Specific binding assay with a prosthetic group as a label component.
  301. Boguslaski Robert C. (Elkhart IN) Carrico Robert J. (Elkhart IN) Christner James E. (Ann Arbor MI), Specific binding assay with an enzyme modulator as a labeling substance.
  302. Schick Lloyd A. (Elkhart IN) Carpenter Stephen K. (Elkhart IN), Specific binding-adsorbent assay test means.
  303. Lawrence Paul J. (Campbell CA) Townsley Charles W. (San Jose CA), Specimen test slide and method for testing occult blood.
  304. Baker Josefina T. (Cupertino CA), Specimen test slide and method of testing for fecal occult blood.
  305. Andersen Harold W. (Oyster Bay NY), Sterilization detection device and method.
  306. Columbus Richard L. (Rochester NY), Structural configuration for transport of a liquid drop through an ingress aperture.
  307. Schutt Ernest G. (Long Valley NJ), Substrate for immunoassay and means of preparing same.
  308. Bolton Bernard (18444 Cornell Southfield MI 48075), Suture extender and needle guard.
  309. Lennon Donald J. (Hopedale MA) Foster Paul B. (Quincy MA), Swab expressor immunoassay device.
  310. Harte Richard A. (Redwood City CA), Test article including a covalently attached diagnostic reagent and method.
  311. Berger Dieter (Mannheim DEX) Biegel Elke (Mannheim DEX) Frey Gnter (Ellerstadt DEX) Murawski Hans-Rdiger (Lampertheim DEX), Test carrier.
  312. Berger Dieter (Viernheim DEX) Knappe Wolfgang-Reinhold (Brstadt DEX) Lorenz Robert (Ludwigshafen IN DEX) Grage ; Jr. Henry M. (Carmel IN) Skarstedt Mark T. (Indianapolis IN) Sojka Bernward (Viernheim, Test carrier and method for the analytical determination of components of body fluids.
  313. Wilk Hans-Erich (Lorsch DEX) Mnter Karin (Mannheim DEX) Lerch Rolf (Ilvesheim DEX), Test carrier for analysis of a sample liquid, method of using a test carrier and process for making a test carrier layer.
  314. Krause Manfred (Viernheim DEX) Klein Bernd (Ludwigshafen DEX) Schindler Gerhard (Grndstadt DEX) Schfer Peter (Ludwigshafen DEX) Ntzel Siegfried (Wilhelmsfeld DEX), Test carrier for analysis of fluids.
  315. Freitag Helmut (Indianapolis IN) Wilk Hans-Erich (Lorsch DEX) Rothe Anselm (Birkenau DEX) Eikmeier Heino (Lorsch DEX), Test carrier for the analysis of a sample liquid.
  316. Freitag Helmut (Indianapolis IN) Rothe Anselm (Birkenau IN DEX) Pollmann Klaus (Indianapolis IN), Test carrier for the analytical determination of a component of a liquid sample.
  317. Schlipfenbacher Reiner (Lampertheim DEX) Steinbiss Joachim (Lorsch DEX), Test carrier for the analytical determination of a component of a liquid sample.
  318. Vogel Peter (Hemsbach DEX) Thym Detlef (Mannheim DEX) Fritz Michael (Rohrheimer DEX) Mosoiu Dan (Limburgerhof DEX), Test carrier for the determination of ions.
  319. Schlipfenbacher Reiner (Lampertheim DEX) Mangold Dieter (Maxdorf DEX) Lerch Rolf (Ilvesheim DEX) Steinbiss Joachim (Lorsch DEX), Test carrier utilizing reaction of two bioaffine binding partners.
  320. Eikmeier Heino (Lorsch DEX) Rothe Anselm (Birkenau DEX), Test carrier with separation means for analyzing a sample fluid.
  321. Johnston Katharine Gentry (Elkhart IN) Greyson Jerome (Elkhart IN), Test composition, device, and method.
  322. Cole Francis X. (Stowe MA) Edwards James H. (Winchester MA) Hendrick Clifford L. (Boxboro MA) VanVoorhis Deborah M. (Watertown MA), Test device.
  323. Deutsch ; Marshall E. ; Mead ; Louis W., Test device.
  324. Johnston Katharine Gentry (Elkhart IN) Smith Melvin Dee (Wakarusa IN), Test device and method for determining a component in a sample.
  325. Deutsch Marshall E. (Sudbury MA) Mead Louis W. (Lexington MA), Test device and method for its use.
  326. Deutsch Marshall E. (Sudbury MA) Mead Louis W. (Lexington MA), Test device and method for its use.
  327. Nelson Roger W. (Fairport NY), Test device containing an immunoassay filter with a flow-delaying polymer.
  328. May Keith (Bedfordshire GB2) Prior Michael E. (Northamptonshire GB2), Test device for detecting an analyte in a liquid sample.
  329. Vonk Glenn P. (Fuquay-Varina NC), Test device including flow control means.
  330. Smith-Lewis Margaret J. (Pittsford NY), Test device with dried reagent drops on inclined wall.
  331. Boguslaski Robert C. (Elkhart IN) Carrico Robert J. (Elkhart IN), Test for Helicobacter pylori.
  332. Verbeck Bruno J. (San Diego CA), Test for a given constituent in a liquid.
  333. Gordon Amirav (Jerusalem IL) Gross Jack (Jerusalem IL), Test for determination of triiodothyronine.
  334. Wie Siong I. (Irvine CA) Kelton Arden A. (Fountain Valley CA) Chung Roy A. (Fountain Valley CA), Test kit for determining the presence of organic materials and method of utilizing same.
  335. Liotta Lance A. (14004 Mont Ave. East Cleveland OH 44112), Test method for separating and/or isolating bacteria and tissue cells.
  336. Terminiello Louis (Sunrise FL) Aronowitz Jack L. (Delray Beach FL), Test strip and fixture.
  337. Gleisner John M. (Lynwood WA), Test strip having a non-particulate dialyzed polymer layer.
  338. Litman David J. (Cupertino CA) Ullman Edwin F. (Atherton CA), Test strip kits in immunoassays and compositions therein.
  339. Engelmann Helmut (Leverkusen DEX), Test strip with adjustable sample absorption capacity.
  340. Gunkel Werner (Rossdorf DEX) Krauss Helmuth (Bensheim DEX), Test strips.
  341. Buechler Kenneth F. (Santee CA) Valkirs Gunars E. (Escondido CA) Anderson Richard R. (Encinitas CA), Threshold ligand-receptor assay.
  342. Buechler Kenneth F. (Santee CA) Valkirs Gunars E. (Escondido CA) Anderson Richard R. (Encinitas CA), Threshold ligand-receptor assay.
  343. Hossom Miles G. (Duluth GA) Jacob Dinesh A. (Girton GBX), Transverse flow diagnostic device.
  344. Hossom Miles G. (Duluth GA), Transverse flow diagnostic kit.
  345. Shah Vipin D. (13568 Debbie La. Saratoga CA 95070) Kulkarni Padmakar v. (6914 Mill Falls Dr. Dallas TX 75248) Miranda Quirinus R. (2097 Jonathan Ave. San Jose CA 95125), Two site cross-reaction immunometric sandwich assay method.
  346. Shah Vipin D. (Saratoga CA) Kulkarni Padmaker V. (Dallas TX) Miranda Quirinus R. (San Jose CA), Two site cross-reaction immunometric sandwich assay method.
  347. Reynolds John H. (Baltimore MD), Unitized solid phase immunoassay kit and method.
  348. McLaurin Daniel A. (Cary NC) Fleming Beverly M. (Raleigh NC) O\Connell James P. (Chapel Hill NC), Vacuum actuated assay device and method of using same.
  349. Matkovich Vlado I. (Glen Cove NY), Vacuum diagnostic device.
  350. Matkovich Vlado I. (Glen Cove NY), Vacuum diagnostic device.
  351. Ward David C. (Guilford CT) Leary Jeffry J. (East Haven CT) Brigati David J. (Hershey PA), Visualization polymers and their application to diagnostic medicine.
  352. Russo Raimondo (Bethesda MD) Liotta Lance A. (Bethesda MD), Vitro cellular interaction with amnion membrane substrate.
  353. Burkhardt Alan E. (Elkhart IN) Genshaw Marvin A. (Elkhart IN) Stover Lon R. (Elkhart IN), Volume independent diagnostic device.
  354. Blatt Joel M. (Granger IN) Heiland Robert (Goshen IN) Morris James R. (South Bend IN) Pugh Jerry (Elkhart IN) Wogoman Frank W. (South Bend IN), Volume metering capillary gap device for applying a liquid sample onto a reactive surface.
  355. Oberhardt Bruce J. (Katonah NY), Whole blood analyses and diffusion apparatus therefor.
  356. Chen Fon-Chiu M. (San Diego CA) Fan Eugene (La Jolla CA), Whole blood assays using porous membrane support devices.

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  4. Chandler, Howard Milne, Apparatus and method for analyte detection.
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  6. Chandler,Howard, Apparatus and method for analyte detection.
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  8. Clark,Scott Marshall; Kepron,Michael Raymond, Bi-directional flow assay device with reagent bridge.
  9. Davis, Paul James; Davis, Mark James; Burnapp, Mark; Thompson, Julie, Binding assay.
  10. Wu, Yuzhang; Yang, Ying; Dai, Jieling; Tung, Hsiaoho Edward, Biological specimen collection and analysis system.
  11. Freitag,Helmut E.; Shi,Qinwei, Chromatographic assay device and methods.
  12. Chandler, Howard Milne, Chromatographic assay or test device.
  13. Sidewell, Steven P.; Bachand, Steven S., Color contrast system for lateral flow immunoassay tests.
  14. Bermudes, David Gordon, Compositions and methods for determining successful immunization by one or more vaccines.
  15. Liang, Greg; Kirby, Kevin J., Device for handling and analysis of a biological sample.
  16. Wu, Yuzhang; Ling, Yun; Dai, Jielin, Devices for detecting analytes in fluid sample.
  17. Shi, Qinwei, Diagnostic devices.
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