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Peptides and compounds that bind to the IL-1 receptor

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-038/00
  • A61K-038/04
출원번호 US-0463076 (1995-06-05)
발명자 / 주소
  • Barrett Ronald W.
  • Yanofsky Stephen D.
출원인 / 주소
  • Affymax Technologies N.V., GBX
대리인 / 주소
    Murphy
인용정보 피인용 횟수 : 56  인용 특허 : 5

초록

where each letter represents the standard one letter abbreviation for an amino acid or an analog thereof; X is selected from the group of natural or unnatural amino acids; Z.sub.37 is a natural or unnatural cyclic amino acid; Z.sub.31 is selected from phenylalanine and acetylated phenylalanine; Z.su

대표청구항

[ We claim:] [1.] A compound of 11 to 40 amino acids in length that binds to an interleukin-1 type I receptor and comprises the sequence EQU Z.sub.23 NZ.sub.24 Z.sub.39 Z.sub.25 Z.sub.26 Z.sub.27 Z.sub.28 Z.sub.29 Z.sub.30 Z.sub.40 re Z.sub.23 is D or Y; Z.sub.24 is D, S, or T; Z.sub.39 is S, T, or

이 특허에 인용된 특허 (5)

  1. Adams Steven P. (St. Charles MO) Bulock Joseph W. (St. Peters MO) Fok Kam F. (St. Louis MO), Bioactive fragment of interleukin-1-B that has antagonistic activity.
  2. Auron Philip E. (Framingham MA) Webb Andrew C. (Wellesley MA) Gehrke Lee (Framingham MA) Dinarello Charles A. (Boston MA) Rosenwasser Lanny J. (Weston MA) Rich Alexander (Cambridge MA) Wolff Sheldon , Human IL-1 cDNA sequences encoding biologically-active human IL-1 proteins.
  3. Hannum Charles H. (Boulder CO) Eisenburg Stephen P. (Boulder CO) Thompson Robert C. (Boulder CO) Arend William P. (Denver CO) Joslin Fenneke G. (Denver CO), Interleukin-1 inhibitors.
  4. Dower Steven K. (Redmond WA) March Carl J. (Seattle WA) Sims John E. (Seattle WA) Urdal David L. (Seattle WA), Interleukin-1 receptors.
  5. Krueger James M. (Germantown TN) Obal ; Jr. Ferenc (Szeged TN HUX) Postlethwaite Arnold E. (Eads TN) Seyer Jerome M. (Memphis TN), Somnogenic fragment of interleukin-1b 상세보기

이 특허를 인용한 특허 (56)

  1. Smith, Craig A.; Wiley, Steven; Kaykas, Ajamete; Probst, Peter, CD47 related compositions and methods for treating immunological diseases and disorders.
  2. Zamora, Paul O.; Atkinson, Brent Lee; Lin, Xinhua; Pena, Louis A., Composition and method for delivery of BMP-2 amplifier/co-activator for enhancement of osteogenesis.
  3. Zamora, Paul O.; Atkinson, Brent Lee; Lin, Xinhua; Pena, Louis A., Composition and method for delivery of BMP-2 amplifier/co-activator for enhancement of osteogenesis.
  4. Zamora, Paul; Atkinson, Brent Lee; Lin, Xinhua; Pena, Louis A., Composition and method for delivery of BMP-2 amplifier/co-activator for enhancement of osteogenesis.
  5. Zamora, Paul; Atkinson, Brent Lee; Lin, Xinhua; Pena, Louis A., Composition and method for delivery of BMP-2 amplifier/co-activator for enhancement of osteogenesis.
  6. Zamora, Paul O.; Atkinson, Brent Lee, Composition comprising BMP-2 amplifier/co-activator for enhancement of osteogenesis.
  7. Anderson, Norman G.; Anderson, N. Leigh; Braatz, James A., Dry deposition of materials for microarrays using matrix displacement.
  8. Zamora, Paul O.; Pena, Louis A.; Lin, Xinhua, Dual chain synthetic heparin-binding growth factor analogs.
  9. Zamora, Paul O.; Pena, Louis A.; Lin, Xinhua, Dual chain synthetic heparin-binding growth factor analogs.
  10. Zamora, Paul O.; Pena, Louis A.; Lin, Xinhua; Takahashi, Kazuyuki, FGF growth factor analogs.
  11. Zamora, Paul O.; Campion, Sarah, Formulations and methods for delivery of growth factor analogs.
  12. Zamora,Paul O.; Pena,Louis A.; Lin,Xinhua, Growth factor analogs.
  13. Pena, Louis A.; Zamora, Paul O.; Lin, Xinhua; Takahashi, Kazuyuki, Heterodimeric chain synthetic heparin-binding growth factor analogs.
  14. Heavner, George A.; Knight, David M.; Ghrayeb, John; Scallon, Bernard J.; Nesspor, Thomas C.; Huang, Chichi, Human EPO mimetic hinge core mimetibodies, compositions, methods and uses.
  15. Zamora, Paul O.; Takahashi, Kazuyuki; Lin, Xinhua, Laminin-derived multi-domain peptides.
  16. Callahan, William J.; Remmele, Jr., Richard L.; Ratnaswamy, Gayathri; Latypov, Ramil F.; Liu, Dingjiang, Lyophilized therapeutic peptibody formulations.
  17. Callahan, William J.; Remmele, Jr., Richard L.; Ratnaswamy, Gayathri; Latypov, Ramil F.; Liu, Dingjiang, Lyophilized therapeutic peptibody formulations.
  18. French Todd E. ; Modlin Douglas N. ; Owicki John C. ; Richey James S. ; Leytes Lev J. ; Razvi Enal S., Methods and apparatus for detecting nucleic acid polymorphisms.
  19. Wiley, Steven; Smith, Craig A; Kaykas, Ajamete, Methods for identifying polypeptide targets and uses thereof for treating immunological diseases.
  20. Anderson, Norman G.; Anderson, N. Leigh, Microarrays and their manufacture.
  21. Anderson, Norman G.; Anderson, N. Leigh, Microarrays and their manufacture.
  22. Anderson, Norman G.; Anderson, N. Leigh; Braatz, James A., Microarrays and their manufacture.
  23. Anderson,N. Leigh; Anderson,Norman G.; Braatz,James A., Microarrays and their manufacture by slicing.
  24. Gegg, Colin V.; Walker, Kenneth W.; Miranda, Leslie P.; Xiong, Fei, Modified Fc molecules.
  25. Gegg, Colin V.; Walker, Kenneth W.; Miranda, Leslie P.; Xiong, Fei, Modified Fc molecules.
  26. Gegg, Colin V.; Walker, Kenneth W.; Miranda, Leslie P.; Xiong, Fei, Modified Fc molecules.
  27. Gegg, Colin; Xiong, Fei; Sitney, Karen C., Modified Fc molecules.
  28. Gegg, Colin; Xiong, Fei; Sitney, Karen C., Modified Fc molecules.
  29. Gegg, Colin; Xiong, Fei; Sitney, Karen C., Modified Fc molecules.
  30. Gegg, Colin; Xiong, Fei; Sitney, Karen C., Modified Fc molecules.
  31. Gegg, Colin; Xiong, Fei; Sitney, Karen C., Modified Fc molecules.
  32. Gegg, Colin; Xiong, Fei; Sitney, Karen C., Modified Fc molecules.
  33. Gegg,Colin; Xiong,Fei; Sitney,Karen C., Modified Fc molecules.
  34. Feige, Ulrich; Liu, Chuan-Fa, Modified peptides as therapeutic agents.
  35. Feige,Ulrich, Modified peptides as therapeutic agents.
  36. Feige,Ulrich, Modified peptides as therapeutic agents.
  37. Feige,Ulrich, Modified peptides as therapeutic agents.
  38. Feige,Ulrich, Modified peptides as therapeutic agents.
  39. Feige,Ulrich; Liu,Chuan Fa; Cheetham,Janet C.; Boone,Thomas Charles; Gudas,Jean Marie, Modified peptides as therapeutic agents.
  40. Boge, Annegret; Lavis, Luke D.; Sportsman, J. Richard; Hoekstra, Merl F.; Huang, Wei, Molecular modification assays.
  41. Boge, Annegret; Sportsman, J. Richard; Gaudet, Elizabeth; Yi, George G., Molecular modification assays.
  42. Huang,Wei; Hoekstra,Merl F.; Sportsman,J. Richard; Terpetschnig,Ewald A., Molecular modification assays.
  43. Zamora, Paul O.; Pena, Louis A.; Lin, Xinhua; Kazuyuki, Takahashi, Positive modulator of bone morphogenic protein-2.
  44. Zamora,Paul O.; Pena,Louis A.; Lin,Xinhua; Takahashi,Kazuyuki, Positive modulator of bone morphogenic protein-2.
  45. Modlin,Douglas N.; Edwards,Glenn R.; Owicki,John C.; Taylor,Michael T.; Marquiss,Samuel A., Sample analysis systems.
  46. Takahashi, Kazuyuki; Zamora, Paul O.; Pena, Louis A.; Lin, Xinhua, Single branch heparin-binding growth factor analogs.
  47. Kozikowski, Alan P., Synthesis of 2-hydroxymethylglutamic acid and congeners thereof.
  48. Pena, Louis A.; Zamora, Paul O.; Lin, Xinhua; Glass, John D., Synthetic heparin-binding factor analogs.
  49. Pe?a,Louis A.; Zamora,Paul; Lin,Xinhua; Glass,John D., Synthetic heparin-binding growth factor analogs.
  50. Walker, Kenneth W.; Kinstler, Olaf B.; Sitney, Karen C., Therapeutic peptides.
  51. Liu, Chuan-Fa; Feige, Ulrich; Cheetham, Janet C., Thrombopoietic compounds.
  52. Liu, Chuan-Fa; Feige, Ulrich; Cheetham, Janet C., Thrombopoietic compounds.
  53. Liu, Chuan-Fa; Feige, Ulrich; Cheetham, Janet C., Thrombopoietic compounds.
  54. Liu, Chuan-Fa; Feige, Ulrich; Cheetham, Janet C., Thrombopoietic compounds.
  55. Liu, Chuan-Fa; Feige, Ulrich; Cheetham, Janet C., Thrombopoietic compounds.
  56. Liu, Chuan-Fa; Feige, Ulrich; Cheetham, Janet C., Thrombopoietic compounds.
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