초록

The present invention provides a drug delivery system containing a pharmaceutically active core and a coating of the core. The coating is comprised of a an emulsifier and a wax. The coating provides rapid dissolution and enhanced long-term stability for the pharmaceutically active ingredient.

대표청구항 ▼

[ What is claimed is:] [1.] A coated particle with a rapid dissolution rate consisting essentially of:a) a pharmaceutically active core;b) a wax coating fracturing easily when chewed comprising:a naturally occurring wax selected from carnauba wax, beeswax, paraffin wax and mixtures thereof with non-

[ What is claimed is:] [1.] A coated particle with a rapid dissolution rate consisting essentially of:a) a pharmaceutically active core;b) a wax coating fracturing easily when chewed comprising:a naturally occurring wax selected from carnauba wax, beeswax, paraffin wax and mixtures thereof with non-polymorphic hydrogenated oil selected from the group consisting of vegetable oil, cottonseed oil, canola oil, palm oil, palm kernal oil and soybean oil vegetable oil which is from about 50 to about 90% by weight of the coating; and an emulsifier the emulsifier selected from polyglycerol esters, polysorbates, mono- and di-glycerides of fatty acid esters and polyoxyethylene derivatives of sorbitan fatty acid esters which is from about 10 to about 50% by weight of the coating;wherein the coated particle has a substantially uniform dissolution profile for six months or more, said particle prepared without water or non-aqueous solvents by applying molten droplets of the melted emulsifier and wax mixture on the surface of the active, and wherein the coated particle has a dissolution profile greater than about 50% at 15 minutes and greater than about 90% at 60 minutes the pharmaceutical active being not delayed but immediately released and available for drug absorption.