초록 ▼

Varying the daily dose of either or both of the estrogen and the progestogen administered for hormone replacement therapy (HRT) is readily and inexpensively accomplished, without the necessity of the physician prescribing a new product each time the daily dose of the estrogen or progestogen is chang

Varying the daily dose of either or both of the estrogen and the progestogen administered for hormone replacement therapy (HRT) is readily and inexpensively accomplished, without the necessity of the physician prescribing a new product each time the daily dose of the estrogen or progestogen is changed, by administering preferably transdermally the estrogen and progestogen contained in separate extrudable pharmaceutical compositions from a dispenser which contains means, preferably adjustable only by the attending physician or dispensing pharmacist, for varying the volume of either or both of the respective compositions which is dispensed as a single dose from the dispenser in response to a defined digital dispensing manipulation of the dispenser.

대표청구항 ▼

[ What is claimed is:] [1.] A dispenser adapted for dispensing and self-administering a plurality of successive individual doses of an estrogen and progestogen from a dispenser containing multiple doses of thereof in separate extrudable pharmaceutically acceptable compositions, in metered single dos

[ What is claimed is:] [1.] A dispenser adapted for dispensing and self-administering a plurality of successive individual doses of an estrogen and progestogen from a dispenser containing multiple doses of thereof in separate extrudable pharmaceutically acceptable compositions, in metered single dosage amounts which can be varied by mechanically modifying the dispenser in combination with which comprises:a) a first container comprising:(i) a first chamber;(ii) a discharge port through which a volume of the first pharmaceutical composition in the first chamber can be discharged therefrom when discharging pressure is applied to the first container;(iii) means for applying discharging pressure to the first chamber;(iv) wherein the first container contains a plurality, of doses of the estrogen in a first extrudable pharmaceutically acceptable composition;b) a second container comprising:(i) a second chamber;(ii) a discharge port through which a volume of the second extrudable pharmaceutical composition in the second chamber can be discharged therefrom when discharging pressure is applied to the second container;(iii) means for applying discharging pressure to the second chamber;(iv) wherein the second container contains a plurality of doses of the progestogen in a second extrudable liquid pharmaceutically acceptable composition;c) a first metering means adapted to receive a volume of the first extrudable pharmaceutical composition extruded thereinto from the first chamber and digitally reciprocally convertible from a receiving mode, where it commnunicates with the first chamber through the first port and where it can be filled with a volume of the first extrudable pharmaceutical composition, to a discharging mode, where a volume of the first extrudable pharmaceutical composition therein can be discharged therefrom and dispensed from the dispenser, which first metering means comprises:(i) a first adjusting means for varying the volume of the first extrudable pharmaceutical composition which can be extruded thereinto;d) a second metering means adapted to receive a volume of the second extrudable pharmaceutical composition extruded thereinto from the second chamber and digitally reciprocally convertible from a receiving mode, where it communicates with the second chamber through the second port and where it can be filled with a volume of the second extrudable pharmaceutical composition, to a discharging mode, where a volume of the second extrudable pharmaceutical composition therein can be discharged therefrom and dispensed from the dispenser, which second metering means comprises:(i) a second adjusting means for varying the volume of the second extrudable pharmaceutical composition which can be extruded thereinto as a single dose of progestogen; ande) dispensing means for dispensing a volume of the first pharmaceutical composition and a volume of the second pharmaceutical composition from the first and second metering means, respectively, from the dispenser as a single does of the estrogen and the progestogen.