초록 ▼

Fixed-dried human blood platelets and processes for preparing them are disclosed. The platelets, upon reconstitution: adhere to thrombogenic surfaces; do not adhere to non-thrombogenic surfaces; undergo shape change (spreading) upon adhering to a thrombogenic surface; adhere to one another to form a

Fixed-dried human blood platelets and processes for preparing them are disclosed. The platelets, upon reconstitution: adhere to thrombogenic surfaces; do not adhere to non-thrombogenic surfaces; undergo shape change (spreading) upon adhering to a thrombogenic surface; adhere to one another to form a hemostatic plug upon adhering to a thrombogenic surface; and release their granular contents. Surgical aids containing such platelets are also disclosed. The platelets are preferably fixed by a fixative such as formaldehyde, paraformaldehyde, or glutaraldehyde, or fixed by a permanganate fixate. The platelets are preferably dried by lyophilization.

대표청구항

[ That which is claimed is:] [1.] A surgical aid, comprising, in combination:a solid, physiologically acceptable substrate; andfixed, dried blood platelets carried by said substrate, wherein said platelets express platelet-derived growth factor on the surface thereof.

[ That which is claimed is:] [1.] A surgical aid, comprising, in combination:a solid, physiologically acceptable substrate; andfixed, dried blood platelets carried by said substrate, wherein said platelets express platelet-derived growth factor on the surface thereof.