초록 ▼

The present invention is directed to a cell encapsulation device that permits rapid and straightforward cell transfer into the device. The preferred device includes components that allow a user to quickly transfer cells into the device with minimal risk to the cells. Among the most important improve

The present invention is directed to a cell encapsulation device that permits rapid and straightforward cell transfer into the device. The preferred device includes components that allow a user to quickly transfer cells into the device with minimal risk to the cells. Among the most important improvements of the present invention are: automatic filtration of excess solution during cell transfer; an instantly wettable cover, allowing ready view into the cell chamber; and a swellable core, allowing cells to be transferred with minimal shear force while assuring optimal cell placement in the device during use. The device of the present invention may be used either in vivo, such as to deliver therapeutic substances, or in vitro, such as to serve as a bioreactor.

대표청구항 ▼

[ What is claimed is:] [1.] A cell encapsulation device comprising:A cell zone comprising a space delimited by a water wettable cover surrounding a cell displacing core within the cover;wherein the cover has a coating thereon, the coating comprising a hydrophilic polymer material cross-linked to its

[ What is claimed is:] [1.] A cell encapsulation device comprising:A cell zone comprising a space delimited by a water wettable cover surrounding a cell displacing core within the cover;wherein the cover has a coating thereon, the coating comprising a hydrophilic polymer material cross-linked to itself, wherein the cover is permeable to water and impermeable to cells such that the cover is a means to filter cells from solution upon introduction of cells and solution into the cell zone under a pressure less than about 6.9.times.10.sup.5 Pa, thereby causing the solution to weep through the cover at a rate ranging from about 0.01 ml/cm.sup.2 /minute to about 100 ml/cm.sup.2 /minute while retaining the cells within the device;wherein the core comprises a swellable material that expands form an initial first radial dimension to an enlarged second radial dimension upon exposure to an aqueous solution;at least ne opening within the cover;a cell delivery device to transfer cells into the device through the opening; andmeans to seal the opening following introduction of cells into the device.