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Multiwall polymeric microspheres 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-009/52
  • B01J-013/12
출원번호 US-0906403 (1992-07-01)
발명자 / 주소
  • Mathiowitz Edith
  • Langer Robert S.
출원인 / 주소
  • Massachusetts Institute of Technology
대리인 / 주소
    Arnall Golden & Gregory, LLP
인용정보 피인용 횟수 : 44  인용 특허 : 9

초록 ▼

A method for preparation of multi-layer polymeric microspheres formed from any degradable or non-degradable polymers which are not soluble in each other at a particular concentration, but which have a positive spreading coefficient in solution. The multi-layer microspheres produced by the method are

대표청구항 ▼

[ We claim:] [1.] Polymeric microspheres formed of a first polymer, a second polymer, and a substance having a particle diameter of fifty microns or less incorporated throughout at least one of the polymers;wherein the first polymer forms a solid spherical, polymeric core not having the substance as

이 특허에 인용된 특허 (9)

  1. Beck Lee R. (Birmingham AL) Flowers ; Jr. Charles F. (Birmingham AL) Cowsar Donald R. (Birmingham AL) Tanquary Albert C. (Birmingham AL), Active/passive immunization of the internal female reproductive organs.
    상세보기
  2. Tayot Jean-Louis (La Tour de Salvagny FRX) Mynard Marie-Claude (Ste. Foy-les-Lepon FRX), Cholera vaccine.
    상세보기
  3. Wellman Russel E. (Pittsford NY) Brown Robert W. (Rochester NY), Encapsulation process.
    상세보기
  4. Jaffe Howard (Gaithersburg MD), Microencapsulation process.
    상세보기
  5. Appelgren Curt H. (V Frlunda SEX) Bogentoft Conny B. (Kallered SEX) Sjgren John A. (Mlnlycke SEX), Pharmaceutical preparation comprising a cardiac glycoside with a polymer coating.
    상세보기
  6. Mathiowitz Edith (Brookline MA) Langer Robert S. (Somerville MA), Preparation of multiwall polymeric microcapsules.
    상세보기
  7. Morishita Masataka (Shizuoka JA) Inaba Yoshihito (Shizuoka JA) Fukushima Mitsuru (Shizuoka JA) Hattori Yoshinori (Shizuoka JA) Kobari Sadami (Shizuoka JA) Matsuda Tetsuo (Shizuoka JA), Process for encapsulation of medicaments.
    상세보기
  8. Lapka Galen G. (Belleville IL) Mason Norbert S. (Clayton MO) Thies Curt (Ballwin MO), Process for preparation of microcapsules.
    상세보기
  9. Gardner David L. (Bellville OH), Process of preparing microcapsules of lactides or lactide copolymers with glycolides and/or e 상세보기

이 특허를 인용한 특허 (44)

  1. O'Gara, John; Puri, Sonali, Compositions and methods for delivery of embolics.
    상세보기
  2. O'Gara, John; Puri, Sonali, Compositions and methods for delivery of embolics.
    상세보기
  3. Bettini, Ruggero; Arduini, Lauro; Bertolini, Francesca; Camellini, Claudia, Compositions of microparticles and granules for oral controlled release of substances for veterinary use.
    상세보기
  4. Evans, Douglas G.; Goldman, Scott M.; Kronengold, Russell T., Devices and methods for treating defects in the tissue of a living being.
    상세보기
  5. Evans, Douglas G; Goldman, Scott M.; Kronengold, Russell T., Devices and methods for treating defects in the tissue of a living being.
    상세보기
  6. Evans, Douglas G; Goldman, Scott M.; Kronengold, Russell T., Devices and methods for treating defects in the tissue of a living being.
    상세보기
  7. Evans, Douglas G; Goldman, Scott M.; Kronengold, Russell T., Devices and methods for treating defects in the tissue of a living being.
    상세보기
  8. Evans, Douglas G; Goldman, Scott M.; Kronengold, Russell T., Devices and methods for treating defects in the tissue of a living being.
    상세보기
  9. Evans, Douglas G; Goldman, Scott M.; Kronengold, Russell T., Devices and methods for treating defects in the tissue of a living being.
    상세보기
  10. Evans, Douglas G; Goldman, Scott M.; Kronengold, Russell T., Devices and methods for treating defects in the tissue of a living being.
    상세보기
  11. Evans, Douglas G; Goldman, Scott M.; Kronengold, Russell T., Devices and methods for treating defects in the tissue of a living being.
    상세보기
  12. Evans,Douglas G.; Goldman,Scott M.; Kronengold,Russell T., Devices and methods for treating defects in the tissue of a living being.
    상세보기
  13. Evans,Douglas G.; Goldman,Scott M.; Kronengold,Russell T., Devices and methods for treating defects in the tissue of a living being.
    상세보기
  14. Evans,Douglas G.; Goldman,Scott M.; Kronengold,Russell T., Devices and methods for treating defects in the tissue of a living being.
    상세보기
  15. Evans,Douglas G; Goldman,Scott M.; Kronengold,Russell T., Devices and methods for treating defects in the tissue of a living being.
    상세보기
  16. Ilyinskii, Petr; Lipford, Grayson B.; Zepp, Charles, Dose selection of adjuvanted synthetic nanocarriers.
    상세보기
  17. Ilyinskii, Petr; Lipford, Grayson B.; Zepp, Charles, Dose selection of adjuvanted synthetic nanocarriers.
    상세보기
  18. Gibson John W. ; Holl Richard J. ; Tipton Arthur J., Emulsion-based processes for making microparticles.
    상세보기
  19. John W. Gibson ; Richard J. Holl ; Arthur J. Tipton, Emulsion-based processes for making microparticles.
    상세보기
  20. Zepp, Charles; Lipford, Grayson B.; Gao, Yun; Johnston, Lloyd; Fu, Fen-ni; Keegan, Mark J.; Baldwin, Sam, Immunomodulatory agent-polymeric compounds.
    상세보기
  21. Zepp, Charles; Lipford, Grayson B.; Gao, Yun; Johnston, Lloyd; Fu, Fen-ni; Keegan, Mark J.; Baldwin, Sam, Immunomodulatory agent-polymeric compounds.
    상세보기
  22. Zepp, Charles; Lipford, Grayson B.; Gao, Yun; Johnston, Lloyd; Fu, Fen-ni; Keegan, Mark J.; Baldwin, Sam, Immunomodulatory agent-polymeric compounds.
    상세보기
  23. Walls, John E.; Putt, Jeffrey W.; DeLine, Kenneth E., Material encapsulation system.
    상세보기
  24. Altreuter, David H.; Griset, Aaron P.; Maldonado, Roberto A., Method for providing polymeric synthetic nanocarriers for generating antigen-specific tolerance immune responses.
    상세보기
  25. Kishimoto, Takashi Kei, Methods and compositions for attenuating exon skipping anti-viral transfer vector immune responses.
    상세보기
  26. Kishimoto, Takashi Kei, Methods and compositions for attenuating gene expression modulating anti-viral transfer vector immune responses.
    상세보기
  27. Mathiowitz, Edith; Thanos, Christopher; Liu, Zhi, Methods for micronization of hydrophobic drugs.
    상세보기
  28. Mathiowitz, Edith; Thanos, Christopher; Liu, Zhi, Methods for micronization of hydrophobic drugs.
    상세보기
  29. Mathiowitz, Edith; Thanos, Christopher; Liu, Zhi, Methods for micronization of hydrophobic drugs.
    상세보기
  30. Zepp, Charles; Gao, Yun, Modified nicotinic compounds and related methods.
    상세보기
  31. Mathiowitz, Edith; Jacob, Jules S.; Chickering, III, Donald E.; Leach, Kathleen Jo, Multiwall polymeric microcapsules from hydrophilic polymers.
    상세보기
  32. Cho, Daniel; Reineke, Joshua; Mathiowitz, Edith; Laulicht, Bryan, Nanoparticle compositions and methods for improved oral delivery of active agents.
    상세보기
  33. Mathiowitz, Edith; Jacob, Jules S.; Chickering, III, Donald E.; Pekarek, Kathleen Jo, Preparation of multiwall polymeric microcapsules from hydrophilic polymers.
    상세보기
  34. Nash, John E.; Evans, Douglas G.; Hoganson, David M., Systems and methods for delivering agents into targeted tissue of a living being.
    상세보기
  35. Nash, John E.; Evans, Douglas G.; Hoganson, David M., Systems and methods for delivering agents into targeted tissue of a living being.
    상세보기
  36. Nash,John E.; Evans,Douglas G.; Hoganson,David M., Systems and methods for delivering agents into targeted tissue of a living being.
    상세보기
  37. Fraser, Christopher; Lipford, Grayson B.; Roy, Christopher J.; Maldonado, Roberto A., Tolerogenic synthetic nanocarriers.
    상세보기
  38. Kishimoto, Takashi Kei; Fraser, Christopher; Maldonado, Roberto A., Tolerogenic synthetic nanocarriers for allergy therapy.
    상세보기
  39. Fraser, Christopher; Kishimoto, Takashi Kei; Maldonado, Roberto A., Tolerogenic synthetic nanocarriers for antigen-specific deletion of T effector cells.
    상세보기
  40. Kishimoto, Takashi Kei; Fraser, Christopher; Maldonado, Roberto A., Tolerogenic synthetic nanocarriers for generating CD8+ regulatory T cells.
    상세보기
  41. Maldonado, Roberto A., Tolerogenic synthetic nanocarriers for inducing regulatory B cells.
    상세보기
  42. Maldonado, Roberto A., Tolerogenic synthetic nanocarriers for inducing regulatory B cells.
    상세보기
  43. Fraser, Christopher; Kishimoto, Takashi Kei; Maldonado, Roberto A., Tolerogenic synthetic nanocarriers to reduce cytotoxic T lymphocyte responses.
    상세보기
  44. Fraser, Christopher; Kishimoto, Takashi Kei; Maldonado, Roberto A., Tolerogenic synthetic nanocarriers to reduce immune responses to therapeutic proteins.
    상세보기

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