초록 ▼

A resorbable, flexible implant in the form of a continuous macro-porous sheet is disclosed. The implant is adapted to protect biological tissue defects, especially bone defects in the mammalian skeletal system, from the interposition of adjacent soft tissues during in vivo repair. The membrane has p

A resorbable, flexible implant in the form of a continuous macro-porous sheet is disclosed. The implant is adapted to protect biological tissue defects, especially bone defects in the mammalian skeletal system, from the interposition of adjacent soft tissues during in vivo repair. The membrane has pores with diameters from 20 microns to 3000 microns. This porosity is such that vasculature and connective tissue cells derived from the adjacent soft tissues including the periosteum can proliferate through the membrane into the bone defect. The thickness of the sheet is such that the sheet has both sufficient flexibility to allow the sheet to be shaped to conform to the configuration of a skeletal region to be repaired, and sufficient tensile strength to allow the sheet to be so shaped without damage to the sheet. The sheet provides enough inherent mechanical strength to withstand pressure from adjacent musculature and does not collapse.

대표청구항 ▼

[ What is claimed is:] [1.] An implant for protecting a biological tissue defect from a prolapse of adjacent soft tissues during in vivo repair of the biological tissue defect, the implant having a pre-implant configuration, which is defined as a configuration of the implant immediately before the i

[ What is claimed is:] [1.] An implant for protecting a biological tissue defect from a prolapse of adjacent soft tissues during in vivo repair of the biological tissue defect, the implant having a pre-implant configuration, which is defined as a configuration of the implant immediately before the implant if formed around and implanted over the biological tissue defect and placed into contact with any adjacent soft tissue, the implant comprising:a substantially planar sheet of resorbable polymer base material excluding paper and having a first side and a second side, the substantially planar sheet of resorbable polymer base material comprising a single layer of resorbable polymer base material between the first side and the second side, the single layer of resorbable polymer base material having a substantially uniform composition; anda plurality or apertures disposed in the substantially planar sheet or resorbable polymer base material, the plurality of apertures being substantially uniformly distributed over both the first side and the second side of the substantially planar sheet or resorbable polymer base material, each of the plurality of apertures of the implant when the implant is in the pre-implant configuration having a diameter which is between about 500 microns and about 3000 microns and which defines an isolated, non-intersecting, fluid-flow path from the first side to the second side;wherein the implant comprises a configuration and strength sufficient to prevent prolapse of adjacent soft tissues into the biological tissue defect, when the implant is formed around and implanted over the biological tissue defect and placed into contact with any adjacent soft tissue; andwherein each of the plurality of apertures of the substantially planar sheet or resorbable polymer base material immediately after implanting of the substantially planar sheet of resorbable polymer base material over the biological tissue defect, has a diameter sufficient in size to allow a proliferation of vasculature and connective tissue cells, derived from adjacent soft tissues, to permeate through the aperture and substantially into the biological tissue defect.